scholarly journals Maltotriose Conjugated Metal–Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages

2020 ◽  
Vol 3 (8) ◽  
pp. 2000029 ◽  
Author(s):  
Yoshie Sakamaki ◽  
John Ozdemir ◽  
Alda Diaz Perez ◽  
Zachary Heidrick ◽  
Olivia Watson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Metal Organic Frameworks ◽  
Tumor Associated Macrophages ◽  
Selective Targeting ◽  
Metal Organic

scholarly journals Sulforaphane Impacts Invasion Capacity and Proliferation of Triple Negative Breast Cancer Cells Grown in the Presence of Tumor-associated Macrophages (P05-003-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Katherine Jensen ◽  
Ed Slattery ◽  
Lauren Housley ◽  
Emilee Hansen
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Vehicle Control ◽  
Tumor Associated Macrophages ◽  
Cell Counts ◽  
Proliferation And Invasion ◽  
Invasion Capacity

Abstract Objectives Triple negative breast cancer (TNBC) accounts for 12% to 24% of all breast cancer cases and is characterized by higher proliferation rates and an increased likelihood of tissue invasion. Tumor cells and cells in the tumor microenvironment (TME), specifically tumor associated macrophages (TAMs), interact through signaling (e.g., cytokines) to promote cancer progression by increasing proliferation and invasion capacity. Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables (i.e., broccoli) that has shown promising results in hindering TNBC progression. SFN reduced proliferation in breast cancer cells and altered cytokine signaling between breast cancer cells and cells in the TME (adipocytes). SFN also decreased invasion markers in TNBC cells grown in isolation. However, TAMs promote tumor cell aggression, and SFN's effect in multicellular environments is unclear. To determine SFN's potential in cancer treatment, it is critical to investigate SFN's effect on proliferation and invasion capacity of TNBC cells grown under TAMs influence, not just grown in isolation. The objective of this study was to determine if SFN can reduce proliferation and invasion capacity of TNBC cells grown in TAM secretions. Methods For cell proliferation, TNBC cells (MDA-MB-231) were exposed to TAM secretions using conditioned media and were then treated with SFN (10 μM) or DMSO vehicle control for 24 and 48 hours. Proliferation was measured using a MTT-based assay and cell counts. For invasion, TAMS and TNBC cells were co-cultured for 48 hours in transwell plates. Prior to co-culture period, cells were treated with SFN (15 μM) or vehicle control. Invasion capacity was measured through a transwell invasion assay with collagen representing the tumor basement membrane. ANOVA and t-tests were used to determine statistical differences with significance at P = 0.05. Results Preliminary analysis revealed significant reductions in proliferation for TAM exposed TNBC cells after 24 hours (P = 0. 0132) and 48 hours (P = 0. 0190) of SFN treatment. Conclusions SFN reduced proliferation and can potentially reduce invasion capacity of TNBC cells influenced by TAM secretions thus enhancing future utilization of SFN in TNBC treatment regimens. Funding Sources California State University, Chico.

Ruthenium(ii) complexes as bioorthogonal two-photon photosensitizers for tumour-specific photodynamic therapy against triple-negative breast cancer cells

2021 ◽  
Author(s):  
Mingwei Lin ◽  
Shanshan Zou ◽  
Xinxing Liao ◽  
Yu Chen ◽  
Diqing Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Two Photon

We developed the first Ru(ii) complex-based bioorthogonal two-photon photosensitizers. Through bioorthogonal labelling, they realize effective tumour-specific photodynamic therapy against triple-negative breast cancer cells.

scholarly journals Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy

2017 ◽  
Vol 53 (70) ◽  
pp. 9793-9796 ◽  
Author(s):  
Hai-Hao Han ◽  
Chang-Zheng Wang ◽  
Yi Zang ◽  
Jia Li ◽  
Tony D. James ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Targeted Imaging

We show that supramolecular core–glycoshell nanodots are capable of targeted imaging and photodynamic therapy of liver and triple-negative breast cancer cells.

A mitochondria-targeted BODIPY-Ir(III) conjugate as a photoinduced ROS generator for the oxidative destruction of triple-negative breast cancer cells

2021 ◽  
Author(s):  
Liping Qiao ◽  
Jiangping Liu ◽  
Shi Kuang ◽  
Xinxing Liao ◽  
Junfeng Kou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Research Interest ◽  
Oxidative Destruction ◽  
Alternative Option

Photodynamic therapy (PDT) provides an alternative option to root out localized Triple-negative breast cancer (TNBC) and has been experiencing a surge of research interest over recent years. In this study,...

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