Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds

2020 ◽  
Vol 362 (21) ◽  
pp. 4699-4706
Author(s):  
Fu‐Long Li ◽  
Yan‐Yan Qiu ◽  
Yu‐Cong Zheng ◽  
Fei‐Fei Chen ◽  
Xu–Dong Kong ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Styrene Oxide ◽  
Hydrolysis Of

Enantioselective hydrolysis of racemic styrene oxide by epoxide hydrolase ofRhodosporidium kratochvilovae SYU-08

2003 ◽  
Vol 8 (5) ◽  
pp. 306-308 ◽  
Author(s):  
Ji Won Lee ◽  
Eun Jung Lee ◽  
Seung Sik Yoo ◽  
Sung Hoon Park ◽  
Hee Sook Kim ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Styrene Oxide ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Enantioselective hydrolysis of styrene oxide with the epoxide hydrolase of Sphingomonas sp. HXN-200

2006 ◽  
Vol 17 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Zeya Liu ◽  
Johannes Michel ◽  
Zunsheng Wang ◽  
Bernard Witholt ◽  
Zhi Li
Keyword(s):  
Epoxide Hydrolase ◽  
Styrene Oxide ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

scholarly journals Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium

2017 ◽  
Vol 15 (41) ◽  
pp. 8827-8835 ◽  
Author(s):  
Eila Serrano-Hervás ◽  
Marc Garcia-Borràs ◽  
Sílvia Osuna
Keyword(s):  
Density Functional Theory ◽  
Bacillus Megaterium ◽  
Density Functional ◽  
Epoxide Hydrolase ◽  
Styrene Oxide ◽  
Soluble Epoxide Hydrolase ◽  
Functional Theory ◽  
Vicinal Diols ◽  
Hydrolysis Of

Epoxide hydrolase (EH) enzymes catalyze the hydration of racemic epoxides to yield their corresponding vicinal diols. In this work, the Bacillus megaterium epoxide hydrolase (BmEH)-mediated hydrolysis of racemic styrene oxide (rac-SO) and its para-nitro styrene oxide (rac-p-NSO) derivative are computationally investigated using density functional theory (DFT).

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