Palladium‐Catalyzed Phosphoryl‐Carbamoylation of Alkenes: Construction of Nonbenzylic C( sp 3 )−P(O)R 2 Bonds via C( sp 3 )−Pd(II)−P(O)R 2 Reductive Elimination

2020 ◽  
Vol 362 (14) ◽  
pp. 2970-2975 ◽  
Author(s):  
Chen Chen ◽  
Wan Sun ◽  
Yan Yan ◽  
Fang Yang ◽  
Yuebo Wang ◽  
...  
Keyword(s):  
Reductive Elimination ◽  
Palladium Catalyzed

Computational Study of the Palladium-Catalyzed Carbonylative Synthesis of Aromatic Acid Chlorides: The Synergistic Effect of Pt Bu3 and CO on Reductive Elimination

2016 ◽  
Vol 22 (42) ◽  
pp. 15107-15118 ◽  
Author(s):  
Jeffrey S. Quesnel ◽  
Salvador Moncho ◽  
Kai E. O. Ylijoki ◽  
Gerardo Martin Torres ◽  
Edward N. Brothers ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Computational Study ◽  
Reductive Elimination ◽  
Aromatic Acid ◽  
Acid Chlorides ◽  
Palladium Catalyzed

scholarly journals Palladium-catalyzed regio- and stereoselective synthesis of aryl and 3-indolyl-substituted 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones

2020 ◽  
Vol 16 ◽  
pp. 1084-1091 ◽  
Author(s):  
Valeria Nori ◽  
Antonio Arcadi ◽  
Armando Carlone ◽  
Fabio Marinelli ◽  
Marco Chiarini
Keyword(s):  
Stereoselective Synthesis ◽  
Reductive Elimination ◽  
Aryl Iodide ◽  
Arylboronic Acids ◽  
Palladium Catalyzed

Cascade cyclocarbopalladation of the readily available aryl/alkyl-substituted propargylic amides containing an aryl iodide moiety, followed by Suzuki–Miyaura coupling with arylboronic acids, allowed an efficient regio- and stereoselective synthesis of tetrasubstituted 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones. Moreover, cascade cyclocarbopalladation, followed by the reaction with 2-alkynyltrifluoroacetanilides, accomplished a double cyclization to afford challenging 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones bearing a 3-indolyl substituent through aminopalladation/reductive elimination.

Palladium-Catalyzed Annulation via Acyl C–H Bond Activation

Synlett ◽  
2018 ◽  
Vol 29 (16) ◽  
pp. 2087-2092 ◽  
Author(s):  
Gui Chen ◽  
Xueliang Huang ◽  
Yinghua Yu
Keyword(s):  
Bond Activation ◽  
Reductive Elimination ◽  
Straightforward Manner ◽  
Migratory Insertion ◽  
Palladium Catalyzed

Palladium-catalyzed annulation of ortho-bromobenzaldehydes with aryl diazoesters is achieved via a sequence of palladium carbene migratory insertion, acyl C–H bond activation and reductive elimination of a seven-membered palladacyclic intermediate. A variety of isocoumarin derivatives were furnished in a straightforward manner.

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