Enantioselective Vinylogous Mannich‐Type Reactions to Construct CF 3 S‐Containing Stereocenters Catalysed by Chiral Quaternary Phosphonium Salts

2020 ◽  
Vol 362 (9) ◽  
pp. 1851-1857 ◽  
Author(s):  
Lijun Xu ◽  
Longhui Yu ◽  
Jun Liu ◽  
Hongyu Wang ◽  
Changwu Zheng ◽  
...  
Keyword(s):  
Phosphonium Salts ◽  
Quaternary Phosphonium Salts

The Study of the Conformation and Dynamics of the New Quaternary Phosphonium Salts by NMR Spectroscopy

2014 ◽  
Vol 45 (7) ◽  
pp. 653-665 ◽  
Author(s):  
Oksana Aganova ◽  
Leisan Galiullina ◽  
Albert Aganov ◽  
Yurii Shtyrlin ◽  
Mikhail Pugachev ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Phosphonium Salts ◽  
Quaternary Phosphonium Salts

Orthogonal Investigation of Influencing Factors on the Modification of Montmorillonite by THPC in Acid Conditions

2014 ◽  
Vol 936 ◽  
pp. 1017-1021
Author(s):  
Pan Chen ◽  
Jin Cheng Wang
Keyword(s):  
Reaction Time ◽  
Ion Exchange ◽  
Influencing Factors ◽  
Reaction Temperature ◽  
Orthogonal Test ◽  
Test Results ◽  
Phosphonium Salts ◽  
Exchange Reactions ◽  
Quaternary Phosphonium Salts

Na-MMT was modified with quaternary phosphonium salts, tetramethylolphosphonium chloride (THPC), via ion-exchange reactions, in acid conditions. Different factors such as reaction time , reaction temperature, the types of solvent, and CEC ratios, were investigated using orthogonal test. Results showed that the best combination of these four factors were A1B3C1D1, that is, the type of the solvent was acetone and water (1:1), reaction time was 3h, CEC ratio was 1:1, and the reaction temperature was 80°C.

Peri-Interactions in Naphthalenes, 9 [1]. On Hypercoordination in Non-Quaternary Phosphonium Salts and a Secondary Phosphine with the (8-Dimethylamino-Naphth-1-Yl) Substituent

2003 ◽  
Vol 58 (1) ◽  
pp. 59-73 ◽  
Author(s):  
Günter Paulus Schiemenz ◽  
Christian Näther ◽  
Simon Pörksen
Keyword(s):  
Hydrogen Bonds ◽  
Basic Assumption ◽  
Coupling Constants ◽  
Secondary Phosphine ◽  
Phosphonium Salts ◽  
Silicon Compounds ◽  
Nmr Data ◽  
Yield Information ◽  
Quaternary Phosphonium Salts

Abstract The 31P NMR data of non-quaternary (8-dimethylamino-naphth-1-yl)phosphonium salts, with emphasis on the 1J(31P, 1H) coupling constants, where scrutinized for their potential to yield information about N→P dative interactions. As for δ (29Si) and 1J(29Si, 1H) in the isosteric silanes, the data do not permit conclusions in favour of such interactions. 1J(31P, 1H) of bis(8-dimethylaminonaphth- 1-yl)phosphine in conjunction with the distances d(N···P) invalidates the basic assumption on which the claim of dative N→P/Si bonding in such phosphorus and silicon compounds rests, viz. that N···P/Si distances of ca. 270 pm are evidence for P/Si-hypercoordination. No evidence for hydrogen bonds N···H-P was found.

scholarly journals Derivatization of Rosmarinic Acid Enhances its in vitro Antitumor, Antimicrobial and Antiprotozoal Properties

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1078 ◽  
Author(s):  
Silvia Bittner Fialová ◽  
Martin Kello ◽  
Matúš Čoma ◽  
Lívia Slobodníková ◽  
Eva Drobná ◽  
...  
Keyword(s):  
Rosmarinic Acid ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Fold Increase ◽  
Inhibitory Effect ◽  
Phosphonium Salts ◽  
Ros Scavenging ◽  
Ic50 Values ◽  
Quaternary Phosphonium Salts

On its own, rosmarinic acid possesses multiple biological activities such as anti-inflammatory, antimicrobial, cardioprotective and antitumor properties, and these are the consequence of its ROS scavenging and inhibitory effect on inflammation. In this study, two quaternary phosphonium salts of rosmarinic acid were prepared for the purpose of increasing its penetration into biological systems with the aim of improving its antimicrobial, antifungal, antiprotozoal and antitumor activity. The synthetized molecules, the triphenylphosphonium and tricyclohexylphosphonium salts of rosmarinic acid, exhibited significantly stronger inhibitory effects on the growth of HCT116 cells with IC50 values of 7.28 or 8.13 μM in comparison to the initial substance, rosmarinic acid (>300 μM). For the synthesized derivatives, we detected a greater than three-fold increase of activity against Acanthamoeba quina, and a greater than eight-fold increase of activity against A. lugdunensis in comparison to rosmarinic acid. Furthermore, we recorded significantly higher antimicrobial activity of the synthetized derivatives when compared to rosmarinic acid itself. Both synthetized quaternary phosphonium salts of rosmarinic acid appear to be promising antitumor and antimicrobial agents, as well as impressive molecules for further research.

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