I 2 ‐Mediated Iodization/ [3+2] Cycloaddition/Nucleophilic Addition Tandem Reaction: Synthesis of Polyheterocycles Bearing Furoquinoline and Maleimide

2019 ◽  
Vol 361 (8) ◽  
pp. 1766-1770 ◽  
Author(s):  
Sidong Du ◽  
Chao Pi ◽  
Ting Wan ◽  
Yangjie Wu ◽  
Xiuling Cui
Keyword(s):  
Nucleophilic Addition ◽  
Tandem Reaction ◽  
Reaction Synthesis

scholarly journals Tandem intramolecular cyclisation/1,3-aryl shift in N-(4,4-diethoxybutyl)-1-arylmethanimines (Kazan reaction): synthesis of 3-benzylidene-1-pyrrolines

RSC Advances ◽  
2017 ◽  
Vol 7 (80) ◽  
pp. 50955-50960 ◽  
Author(s):  
A. V. Smolobochkin ◽  
A. S. Gazizov ◽  
A. S. Melyashova ◽  
J. K. Voronina ◽  
A. G. Strelnik ◽  
...  
Keyword(s):  
Mannich Reaction ◽  
Sigmatropic Rearrangement ◽  
Tandem Reaction ◽  
Reaction Synthesis ◽  
Aryl Fragment

A novel tandem reaction, which transforms N-(4,4-diethoxybutyl)imines to 3-arylidene-1-pyrrolines via intramolecular Mannich reaction/[1,3]-sigmatropic rearrangement of the aryl fragment is described.

scholarly journals Correction: Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives

2019 ◽  
Vol 6 (7) ◽  
pp. 1064-1065
Author(s):  
Man Liu ◽  
Chen-Fei Liu ◽  
Jing Zhang ◽  
Yan-Jun Xu ◽  
Lin Dong
Keyword(s):  
Tandem Reaction ◽  
Reaction Synthesis ◽  
Metal Free

Correction for ‘Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives’ by Man Liu et al., Org. Chem. Front., 2019, 6, 664–668.

One-pot three-component tandem reaction: Synthesis of aryl/alkyl cyanamides libraries and their further conversion into tetrazole derivatives

2018 ◽  
Vol 48 (5) ◽  
pp. 500-510 ◽  
Author(s):  
Usharani Mandapati ◽  
Pavan Mandapati ◽  
Srinivasarao Pinapati ◽  
Ramana Tamminana ◽  
Rameshraju Rudraraju
Keyword(s):  
Tandem Reaction ◽  
Reaction Synthesis ◽  
One Pot ◽  
Tetrazole Derivatives

A solvent- and catalyst-free tandem reaction: synthesis, and photophysical and biological applications of isoindoloquinazolinones

2020 ◽  
Vol 44 (11) ◽  
pp. 4324-4331
Author(s):  
Anirban Bera ◽  
Sk Asraf Ali ◽  
Susanta Kumar Manna ◽  
Mohammed Ikbal ◽  
Sandip Misra ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Synthetic Approach ◽  
Reaction Synthesis ◽  
Biological Applications ◽  
Catalyst Free

An easy green synthetic approach for fused isoindoloquinazolinones has been developed under neat reaction (yields up to 91%) conditions.

scholarly journals Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes

2018 ◽  
Vol 14 ◽  
pp. 2916-2922 ◽  
Author(s):  
Muhammad Israr ◽  
Changqing Ye ◽  
Munira Taj Muhammad ◽  
Yajun Li ◽  
Hongli Bao
Keyword(s):  
Carboxylic Acids ◽  
Tandem Reaction ◽  
Reaction Synthesis ◽  
Terminal Alkynes ◽  
Alkyl Azides ◽  
Organic Azides ◽  
Cuaac Reaction ◽  
First Time

A copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported. The alkyl carboxylic acids is for the first time being used as the alkyl azide precursors in the form of alkyl diacyl peroxides. This method avoids the necessity to handle organic azides, as they are generated in situ, making this protocol operationally simple. The Cu(I) catalyst not only participates in the alkyl diacyl peroxides decomposition to afford alkyl azides but also catalyzes the subsequent CuAAC reaction to produce the 1,2,3-triazoles.

Unexpected and intriguing reactivity of α-imino esters and iminium salts

2006 ◽  
Vol 78 (10) ◽  
pp. 1867-1876 ◽  
Author(s):  
Makoto Shimizu
Keyword(s):  
Benzoyl Peroxide ◽  
Nucleophilic Addition ◽  
Coupling Reaction ◽  
Grignard Reagents ◽  
Tandem Reaction ◽  
Amino Esters ◽  
Iminium Salts ◽  
Iminium Salt ◽  
Oxidative Removal ◽  
Imino Esters

An intriguing umpolung of the reactivity of imines possessing electron-withdrawing groups was observed. For example, N-alkylation-coupling reaction of the imines derived from glyoxylates was conducted with dialkylaluminum chloride in acetonitrile to give N-monoalkylated 1,2-diamines in good yields. On treatment of various α-imino esters with organoaluminum reagents and allyltributyltin in the presence of benzoyl peroxide (BPO), the tandem reaction proceeded to give the N-alkylation/C-allylation products in good yields. Diethyl 2-[N-(p-methoxyphenyl)imino]-malonate underwent amination reactions with alkyl Grignard reagents to give N-alkylation products in good yields. The obtained N-alkylation products were readily converted into N-alkyl-p-anisidines by the oxidative removal of the malonate moiety. In order to enhance the reactivity of imines, an iminium salt was prepared using the oxidation of amino ketene silyl acetal with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), and the subsequent nucleophilic addition to this iminium species proceeded to afford α-amino esters in good yields.

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