Iodine‐Promoted One‐pot Synthesis of Highly Substituted 4‐Aminopyrroles and Bis‐4‐aminopyrrole from Aryl Methyl Ketones, Arylamines, and Enamines

2018 ◽  
Vol 360 (21) ◽  
pp. 4073-4079 ◽  
Author(s):  
Hitesh B. Jalani ◽  
Jyotirling R. Mali ◽  
Hyejun Park ◽  
Jae Kyun Lee ◽  
Kiho Lee ◽  
...  
Keyword(s):  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Aryl Methyl

Iodine-mediated one-pot synthesis of C-3 acylated indolizines from pyridines, aryl methyl ketones and acrylate derivatives

Tetrahedron ◽  
2019 ◽  
Vol 75 (27) ◽  
pp. 3767-3771 ◽  
Author(s):  
Youlai Fang ◽  
Lisheng He ◽  
Weidong Pan ◽  
Yuzhu Yang
Keyword(s):  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Aryl Methyl

A Facile One-Pot Synthesis of 1-Aryl-2-(dimethylaminomethyl)prop-2-en-1-ones from Aryl Methyl Ketones

Synthesis ◽  
1998 ◽  
Vol 1998 (05) ◽  
pp. 715-717 ◽  
Author(s):  
Ulrich Girreser ◽  
Dieter Heber ◽  
Martin Schütt
Keyword(s):  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Aryl Methyl

Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽  
2020 ◽  
Vol 31 (14) ◽  
pp. 1430-1434
Author(s):  
Ming Bian ◽  
Jin-feng Zhou ◽  
Dong-min Tang
Keyword(s):  
Drug Discovery ◽  
Dimethyl Sulfoxide ◽  
Functional Groups ◽  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

Difluorohomologization-Halogenation of Methyl Ketones: One-Pot Synthesis of β-Halo-α,α-Difluoroketones

2018 ◽  
Vol 76 (12) ◽  
pp. 983 ◽  
Author(s):  
Xiaoning Song ◽  
Shan Yang ◽  
Xin Wang ◽  
Mang Wang
Keyword(s):  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis
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