Synthesis of Diverse Nitrogen Heterocycles via Palladium-Catalyzed Tandem Azide-Isocyanide Cross-Coupling/Cyclization: Mechanistic Insight using Experimental and Theoretical Studies

2017 ◽  
Vol 360 (2) ◽  
pp. 290-297 ◽  
Author(s):  
Arshad J. Ansari ◽  
Ramdas S. Pathare ◽  
Antim K. Maurya ◽  
Vijai K. Agnihotri ◽  
Shahnawaz Khan ◽  
...  
Keyword(s):  
Nitrogen Heterocycles ◽  
Cross Coupling ◽  
Theoretical Studies ◽  
Mechanistic Insight ◽  
Palladium Catalyzed ◽  
Experimental And Theoretical Studies

scholarly journals Mechanistic insight into hydroxamate transfer reaction mimicking the inhibition of zinc-containing enzymes

2020 ◽  
Vol 11 (33) ◽  
pp. 9017-9021
Author(s):  
Nam Kwon ◽  
Jong-Min Suh ◽  
Mi Hee Lim ◽  
Hajime Hirao ◽  
Jaeheung Cho
Keyword(s):  
Metal Complexes ◽  
Transfer Reaction ◽  
Theoretical Studies ◽  
Mechanistic Insight ◽  
Experimental And Theoretical Studies ◽  
Insight Into

A hydroxamate transfer reaction between metal complexes has been investigated by a combination of experimental and theoretical studies.

Experimental and theoretical studies on nickel–zinc-catalyzed cross-coupling of gem-dibromoalkenes with P(O)–H compounds

RSC Advances ◽  
2014 ◽  
Vol 4 (5) ◽  
pp. 2322-2326 ◽  
Author(s):  
Liu Liu ◽  
Ye Lv ◽  
Yile Wu ◽  
Xiang Gao ◽  
Zhiping Zeng ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Theoretical Studies ◽  
Nickel Zinc ◽  
Experimental And Theoretical Studies

Palladium-catalyzed diastereoselective cross-coupling of two aryl halides via C–H activation: synthesis of chiral eight-membered nitrogen heterocycles

2021 ◽  
Vol 57 (23) ◽  
pp. 2939-2942 ◽  
Author(s):  
Cang Cheng ◽  
Xiang Zuo ◽  
Dongdong Tu ◽  
Bin Wan ◽  
Yanghui Zhang
Keyword(s):  
Nitrogen Heterocycles ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Aryl Halides ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
Novel Strategy

The diastereoselective cross-coupling reaction of two aryl halides has been developed through C–H activation. The reaction represents a novel strategy for the construction of chiral eight-membered nitrogen heterocycles.

Suzuki–Miyaura cross-coupling for chemoproteomic applications

2020 ◽  
Author(s):  
Jian Cao ◽  
Ernest Armenta ◽  
Lisa Boatner ◽  
Heta Desai ◽  
Neil Chan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cross Coupling ◽  
Protein Profiling ◽  
Protein Labeling ◽  
Caspase 8 ◽  
Complex Cell ◽  
Bioorthogonal Chemistry ◽  
Reaction Conditions ◽  
Target Deconvolution ◽  
Palladium Catalyzed

Bioorthogonal chemistry is a mainstay of chemoproteomic sample preparation workflows. While numerous transformations are now available, chemoproteomic studies still rely overwhelmingly on copper-catalyzed azide –alkyne cycloaddition (CuAAC) or 'click' chemistry. Here we demonstrate that gel-based activity-based protein profiling (ABPP) and mass-spectrometry-based chemoproteomic profiling can be conducted using Suzuki–Miyaura cross-coupling. We identify reaction conditions that proceed in complex cell lysates and find that Suzuki –Miyaura cross-coupling and CuAAC yield comparable chemoproteomic coverage. Importantly, Suzuki–Miyaura is also compatible with chemoproteomic target deconvolution, as demonstrated using structurally matched probes tailored to react with the cysteine protease caspase-8. Uniquely enabled by the observed orthogonality of palladium-catalyzed cross-coupling and CuAAC, we combine both reactions to achieve dual protein labeling.

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