Metal-Free Nitration of the C(sp 3 )−H Bonds of 2-Oxindoles through Radical Coupling Reaction at Room Temperature

2017 ◽  
Vol 359 (20) ◽  
pp. 3551-3554 ◽  
Author(s):  
Wen-Ting Wei ◽  
Wen-Ming Zhu ◽  
Wei-Wei Ying ◽  
Yi-Ning Wang ◽  
Wen-Hui Bao ◽  
...  
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Metal Free ◽  
Radical Coupling ◽  
Radical Coupling Reaction

Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds via visible-light photocatalyst in water

2020 ◽  
Vol 22 (2) ◽  
pp. 336-341 ◽  
Author(s):  
Shulei Pan ◽  
Min Jiang ◽  
Jinjin Hu ◽  
Ruigang Xu ◽  
Xiaofei Zeng ◽  
...  
Keyword(s):  
Amino Acids ◽  
Visible Light ◽  
Carbonyl Compounds ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Amino Alcohols ◽  
Visible Light Photocatalyst ◽  
Radical Coupling ◽  
Decarboxylative Coupling ◽  
Radical Coupling Reaction

A general and efficient visible-light photoredox-catalyzed decarboxylative radical coupling reaction of N-aryl amino acids with aldehydes or ketones for the synthesis of 1,2-amino alcohols in water at room temperature is described.

Iron-catalyzed synthesis of arylsulfinates through radical coupling reaction

2016 ◽  
Vol 52 (14) ◽  
pp. 2980-2983 ◽  
Author(s):  
Weixi Zhang ◽  
Meiming Luo
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Radical Coupling ◽  
Diaryliodonium Salts ◽  
Radical Coupling Reaction

A novel iron-catalyzed synthesis of arylsulfinates from diaryliodonium salts and rongalite through radical coupling reaction is described. Desired products can be prepared in good yields in air at room temperature in 20 minutes without the need for any ligands and additives.

Visible light-induced alkylpyridylation of styrenes via a reductive radical three-component coupling

2021 ◽  
Author(s):  
Jingmiao Yu ◽  
Liwen Zhu ◽  
Huan Gao ◽  
Xiaoyuan Hong ◽  
Tingting Chen
Keyword(s):  
Visible Light ◽  
Coupling Reaction ◽  
Metal Free ◽  
Radical Coupling ◽  
Radical Coupling Reaction ◽  
Three Component Coupling

A visible light-induced and metal-free strategy for the intermolecular three-compoment alkylpyridylation of styrenes is reported. Hantzsch ester was found to be key to initiate the overall reductive radical coupling reaction....

Transition-Metal-Free Synthesis of Thiosulfonates through Radical Coupling Reaction

Synlett ◽  
2018 ◽  
Vol 29 (15) ◽  
pp. 2076-2080 ◽  
Author(s):  
Wen-Ting Wei ◽  
Zhiyong Guo ◽  
Guodong Zhou ◽  
Xu-Dong Xu ◽  
Gan-Ping Chen
Keyword(s):  
Transition Metal ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Mechanistic Studies ◽  
Reaction Conditions ◽  
Coupling Process ◽  
Metal Free ◽  
Radical Coupling ◽  
Radical Coupling Reaction ◽  
High Yields

An efficient and practical transition-metal-free radical ­coupling reaction of sulfonyl hydrazides mediated by NIS/K2S2O8 has been developed to afford a variety of biological activity thiosulfonates in moderate to excellent yields. Compared to a known approach for the synthesis of thiosulfonates from sulfonyl hydrazides, this strategy features high yields, mild reaction conditions, and broad substrate scope. The mechanistic studies revealed that the procedure undergoes via a radical cross-coupling process for the construction of S–S bonds.

Transition-metal-free decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1H)-ones with α,α-difluoroarylacetic acids

2019 ◽  
Vol 6 (8) ◽  
pp. 1173-1182 ◽  
Author(s):  
Guangfeng Hong ◽  
Jinwei Yuan ◽  
Junhao Fu ◽  
Guoyong Pan ◽  
Zhengwang Wang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Coupling Reaction ◽  
Metal Free ◽  
Radical Coupling ◽  
Mild Conditions ◽  
Radical Coupling Reaction

A facile and efficient transition-metal-free decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with quinoxalin-2(1H)-ones has been developed under mild conditions.

C(sp3)–H Peroxidation of 3-Substituted Indolin-2-ones under Metal-Free Conditions

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 663-667 ◽  
Author(s):  
Wen-Ting Wei ◽  
Wei-Wei Ying ◽  
Wen-Ming Zhu ◽  
Zhanghua Gao ◽  
Hongze Liang
Keyword(s):  
Coupling Reaction ◽  
Butyl Hydroperoxide ◽  
Metal Free ◽  
Efficient Approach ◽  
Tert Butyl ◽  
Radical Coupling ◽  
Simple Strategy ◽  
Tert Butyl Hydroperoxide ◽  
Radical Coupling Reaction

A C(sp3)–H peroxidation of 3-substituted indolin-2-ones through radical coupling reaction has been developed under metal-free conditions. Using tert-butyl hydroperoxide both as an oxidant and as a peroxidation reagent to couple with the C(sp3)–H bonds of 3-substituted indolin-2-ones can form a new C–O bond without using any additives. This simple strategy provides a green and efficient approach to 3-peroxyindolin-2-ones in moderate to excellent yields. The resulting 3-peroxyindolin-2-ones could be further transformed into 3-hydroxy­indolin-2-ones.

Photocatalyzed redox-neutral decarboxylative alkylation of heteroaryl methanamines

2021 ◽  
Vol 23 (2) ◽  
pp. 774-779
Author(s):  
Pengfei Niu ◽  
Jingya Yang ◽  
Yong Yuan ◽  
Yongxin Zhang ◽  
Chenxing Zhou ◽  
...  
Keyword(s):  
Copper Complex ◽  
Coupling Reaction ◽  
Blue Led ◽  
Radical Coupling ◽  
Radical Coupling Reaction ◽  
Led Irradiation

A redox-neutral decarboxylative radical–radical coupling reaction of heteroaryl methylamines with NHPI esters has been developed by employing a copper complex as a photocatalyst with blue LED irradiation.

Room-Temperature, Water-Promoted, Radical-Coupling Reactions of Phenols with tert-Butyl Nitrite

Synlett ◽  
2017 ◽  
Vol 28 (16) ◽  
pp. 2153-2156 ◽  
Author(s):  
Wen-Ting Wei ◽  
Hongze Liang ◽  
Wen-Ming Zhu ◽  
Weida Liang ◽  
Yi Wu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Phenol Derivative ◽  
Tert Butyl ◽  
Radical Coupling ◽  
Air Atmosphere ◽  
Cross Coupling Reaction ◽  
Temperature Water

A radical–radical cross-coupling reaction of phenols with tert-butyl nitrite has been developed with the use of water as an additive. This method allows the construction of C–N bonds under an air atmosphere at room temperature, providing the ortho-nitrated phenol derivative in moderate to good yields.

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