Metal-Free Activation of DMF by Dioxygen: A Cascade Multiple-Bond-Formation Reaction to Synthesize 3-Acylindoles from 2-Alkenylanilines

2017 ◽  
Vol 359 (19) ◽  
pp. 3460-3467 ◽  
Author(s):  
Ji-Bo Wang ◽  
Yin-Long Li ◽  
Jun Deng
Keyword(s):  
Multiple Bond ◽  
Bond Formation ◽  
Formation Reaction ◽  
Metal Free

scholarly journals Catalytic Conversion of Carbon Dioxide through C-N Bond Formation

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 182 ◽  
Author(s):  
Jing-Yuan Li ◽  
Qing-Wen Song ◽  
Kan Zhang ◽  
Ping Liu
Keyword(s):  
Carbon Dioxide ◽  
Catalytic Mechanism ◽  
Bond Formation ◽  
Catalytic Efficiency ◽  
Chemical Fixation ◽  
Catalytic Systems ◽  
Formation Reaction ◽  
Metal Free ◽  
The Past ◽  
Regulatory Strategies

From the viewpoint of green chemistry and sustainable development, it is of great significance to synthesize chemicals from CO2 as C1 source through C-N bond formation. During the past several decade years, many studies on C-N bond formation reaction were involved, and many efforts have been made on the theory. Nevertheless, several great challenges such as thermodynamic limitation, low catalytic efficiency and selectivity, and high pressure etc. are still suffered. Herein, recent advances are highlighted on the development of catalytic methods for chemical fixation of CO2 to various chemicals through C-N bond formation. Meanwhile, the catalytic systems (metal and metal-free catalysis), strategies and catalytic mechanism are summarized and discussed in detail. Besides, this review also covers some novel synthetic strategies to urethanes based on amines and CO2. Finally, the regulatory strategies on functionalization of CO2 for N-methylation/N-formylation of amines with phenylsilane and heterogeneous catalysis N-methylation of amines with CO2 and H2 are emphasized.

H2-Generation from Alcohols by the MOF-Based Noble Metal-Free Photocatalyst Ni/CdS/TiO2@MIL-101

2019 ◽  
Vol 72 (10) ◽  
pp. 842 ◽  
Author(s):  
Dominic Tilgner ◽  
Mara Klarner ◽  
Sebastian Hammon ◽  
Martin Friedrich ◽  
Andreas Verch ◽  
...  
Keyword(s):  
Noble Metal ◽  
Metal Organic Framework ◽  
Multiple Bond ◽  
Bond Formation ◽  
Metal Free ◽  
Fossil Carbon ◽  
Gas Atmosphere ◽  
Metal Organic ◽  
Hydrogen Liberation ◽  
Activation Of Alcohols

The synthesis of important classes of chemical compounds from alcohols helps to conserve Earth’s fossil carbon resources, since alcohols can be obtained from indigestible and abundantly available biomass. The utilisation of visible light for the activation of alcohols permits alcohol-based C–N and C–C bond formation under mild conditions inaccessible with thermally operating hydrogen liberation catalysts. Herein, we report on a noble metal-free photocatalyst able to split alcohols into hydrogen and carbonyl compounds under inert gas atmosphere without the requirement of electron donors, additives, or aqueous reaction media. The reusable photocatalyst mediates C–N multiple bond formation using the oxidation of alcohols and subsequent coupling with amines. The photocatalyst consists of a CdS/TiO2 heterojunction decorated with co-catalytic Ni nanoparticles and is prepared on size-optimised colloidal metal–organic framework (MOF) crystallites.

Stereodivergent Alkyne Hydrofluorination Using a Simple Practical Reagent

2020 ◽  
Author(s):  
Rui Guo ◽  
Xiaotian Qi ◽  
Hengye Xiang ◽  
Paul Geaneoates ◽  
Ruihan Wang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Biologically Active ◽  
Dft Studies ◽  
Thermodynamic Control ◽  
Important Goal ◽  
Peptide Bonds ◽  
Metal Free ◽  
Vinyl Cation ◽  
E And Z Isomers ◽  
Vinyl Fluorides

Vinyl fluorides play an important role in drug development as they serve as bioisosteres for peptide bonds and are found in a range of biologically active molecules. The discovery of safe, general and practical procedures to prepare vinyl fluorides remains an important goal and challenge for synthetic chemistry. Here we introduce an inexpensive and easily-handled reagent and report simple, scalable, and metal-free protocols for the regioselective and stereodivergent hydrofluorination of alkynes to access both the E and Z isomers of vinyl fluorides. These conditions were suitable for a diverse collection of alkynes, including several highly-functionalized pharmaceutical derivatives. Mechanistic and DFT studies support C–F bond formation through a vinyl cation intermediate, with the (E)- and (Z)-hydrofluorination products forming under kinetic and thermodynamic control, respectively.<br>

Formation of Carbon-Oxygen Bond Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions

2020 ◽  
Vol 17 ◽  
Author(s):  
Ayesha Jalil ◽  
Yaxin O Yang ◽  
Zhendong Chen ◽  
Rongxuan Jia ◽  
Tianhao Bi ◽  
...  
Keyword(s):  
Natural Products ◽  
Bond Formation ◽  
Building Blocks ◽  
Review Article ◽  
Hypervalent Iodine ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
The Past ◽  
Oxygen Bond ◽  
Privileged Scaffolds

: Hypervalent iodine reagents are a class of non-metallic oxidants have been widely used in the construction of several sorts of bond formations. This surging interest in hypervalent iodine reagents is essentially due to their very useful oxidizing properties, combined with their benign environmental character and commercial availability from the past few decades ago. Furthermore, these hypervalent iodine reagents have been used in the construction of many significant building blocks and privileged scaffolds of bioactive natural products. The purpose of writing this review article is to explore all the transformations in which carbon-oxygen bond formation occurred by using hypervalent iodine reagents under metal-free conditions

scholarly journals Chemoselective bioconjugation based on modular click chemistry with 4-halocoumarins and aryl sulfonates

RSC Advances ◽  
2021 ◽  
Vol 11 (31) ◽  
pp. 18960-18965
Author(s):  
F. Yushra Thanzeel ◽  
Christian Wolf
Keyword(s):  
Click Chemistry ◽  
Bond Formation ◽  
Metal Free

We report chemoselective and modular peptide bioconjugation using stoichiometric amounts of 4-halocoumarin and arylsulfonate agents that undergo metal-free C(sp2)-heteroatom bond formation at micromolar concentrations.

Sunlight-induced C C bond formation reaction: Radical addition of alcohols/ethers/acetals to olefins

2021 ◽  
Vol 413 ◽  
pp. 113263
Author(s):  
Mamiko Hayakawa ◽  
Hisashi Shirota ◽  
Souta Hirayama ◽  
Ryuusei Yamada ◽  
Tadashi Aoyama ◽  
...  
Keyword(s):  
Bond Formation ◽  
Radical Addition ◽  
Formation Reaction

Metal-Free Synthesis of 2-Oxindoles via PhI(OAc)2-Mediated Oxidative C–C Bond Formation

2014 ◽  
Vol 79 (3) ◽  
pp. 1111-1119 ◽  
Author(s):  
Jinglei Lv ◽  
Daisy Zhang-Negrerie ◽  
Jun Deng ◽  
Yunfei Du ◽  
Kang Zhao
Keyword(s):  
Bond Formation ◽  
Metal Free
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