Scope and Post-Transformations for the Borane-Isocyanide Multicomponent Reactions: Concise Access to Structurally Diverse Heterocyclic Compounds

2013 ◽  
Vol 355 (16) ◽  
pp. 3273-3284 ◽  
Author(s):  
Nicola Kielland ◽  
Esther Vicente-García ◽  
Marc Revés ◽  
Nicolas Isambert ◽  
María José Arévalo ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Multicomponent Reactions

scholarly journals One pot synthesis of 3, 4-dihydropyrimidine-2(1H)-thiones using orange peel powder under ultrasonic irradiation

2020 ◽  
Vol 9 (1) ◽  
pp. 919-923
Keyword(s):  
Reaction Time ◽  
Ultrasonic Irradiation ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Orange Peel ◽  
Biologically Active ◽  
High Yield ◽  
Atom Economy ◽  
One Pot ◽  
The Past

Biginelli, an important multicomponent reaction provides an avenue for the synthesis of different biologically active heterocyclic compounds. During the past decade, one pot multicomponent reactions have attracted the attention of organic and medicinal chemists due to high atom economy, time and enery saving convergent nature. The present manuscript reports a simple one pot three component synthesis of 3, 4-dihydroprimidin-2(1H)-thiones from various diversely substituted aldehydes, ethyl acetoacetate and thiourea using a orange peel powder as a natural catalyst on ultrasonic irradiation in aqueous medium as the solvent. The advantages of this reaction are less reaction time, high yield, easy availability of the catalyst and green nature.

The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions

2019 ◽  
Vol 23 (4) ◽  
pp. 1029-1064
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Razieh Moradi ◽  
Tahereh Ahmadi ◽  
Parisa Gholamzadeh
Keyword(s):  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Molecular Diversity

Palladium-mediated cascade or multicomponent reactions: A new route to carbo- and heterocyclic compounds

2006 ◽  
Vol 78 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Geneviève Balme ◽  
Didier Bouyssi ◽  
Nuno Monteiro
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Addition Reaction ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Nucleophiles ◽  
Carbon Carbon Bond

In recent years, new processes based on transition-metal-mediated intramolecular addition reaction of heteronucleophiles and stabilized carbon nucleophiles to unactivated alkenes and alkynes have been developed in our laboratory. In this article, we summarize a number of recent synthetic applications of these new processes. Emphasis is placed on the development of multicomponent reactions based on a Pd-mediated intramolecular cyclization coupled with a carbon-carbon bond-forming reaction. Applications of this methodology to the synthesis of natural lignans are also reported.

Recent Advances in C-C/Heteroatom Bond Forming and Annulation Reactions of β-Ketodithioesters

2021 ◽  
Vol 18 ◽  
Author(s):  
Laishram Momota Devi ◽  
Thokchom Prasanta Singh ◽  
Okram Mukherjee Singh
Keyword(s):  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Building Blocks ◽  
Heterocyclic Synthesis ◽  
Bond Forming ◽  
Mild Conditions ◽  
The Past ◽  
Rapid Construction ◽  
Fresh Perspective ◽  
Good Number

: β Ketodithioesters (KDEs) are versatile building blocks for the rapid construction of various heterocyclic compounds. Quite a good number of successful reactions based on KDEs have been developed in the past decade for the construction of heterocyclic skeletons under mild conditions. This review covers the new C-C/X bond formation and annulation reactions of KDEs with dielectrophilic or dinucleophilic reagents. Multicomponent reactions using KDEs to construct various heterocycles are also the major contents in this review. Objective: The aim of this review is to bring a fresh perspective on the application of KDEs in organic synthesis covering from 2013 to 2020. Conclusion: From this review, it is clear that KDEs have been the object of numerous studies on its use in heterocyclic synthesis. The presence of different functional groups on this synthon permits the incorporation of C-C/X sources into the final targets, which is the beauty of KDEs.

scholarly journals Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

2016 ◽  
Vol 12 ◽  
pp. 1269-1301 ◽  
Author(s):  
Mohammad Haji
Keyword(s):  
Organic Compounds ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Synthetic Chemistry ◽  
Phosphonate Group ◽  
Wide Range ◽  
Efficient Route ◽  
Organophosphorus Chemistry

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

Synthesis of Heterocyclic Compounds through Multicomponent Reactions using 6-Aminouracil as starting reagent

2021 ◽  
Vol 25 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Marzieh Rad ◽  
Fatemeh Mohajer ◽  
Hitesh Sehrawat ◽  
Ravi Tomar
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Essential Components

: The analogs of 6-Amino uracil are essential components due to their biological activity. The uracil is used as an important component for the synthesis of heterocyclic compounds like pyrrolo-, pyrido-, pyrimidine-pyrimido scaffolds. Herein, the application of this compound is reviewed as a precursor in the synthesis of many heterocyclic cores from 2016 to 2020.

scholarly journals Isocyanide-based multicomponent reactions in the synthesis of heterocycles

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 53203-53272 ◽  
Author(s):  
Samahe Sadjadi ◽  
Majid M. Heravi ◽  
Niousha Nazari
Keyword(s):  
Heterocyclic Compounds ◽  
Multicomponent Reactions

In this review, we update our previous presentation, underscoring the recent applications of isocyanides as privileged synthons in the synthesis of various heterocyclic compounds, especially focused on those synthesizedviamulticomponent reactions.

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