A Three-Way Switchable Process for Suzuki Cross-Coupling, Hydrodehalogenation, or an Assisted Tandem Hydrodehalogenation and Suzuki Cross-Coupling Sequence

2013 ◽  
Vol 355 (16) ◽  
pp. 3231-3243 ◽  
Author(s):  
Alexander H. Sandtorv ◽  
Hans-René Bjørsvik
Keyword(s):  
Cross Coupling ◽  
Coupling Sequence

scholarly journals Total synthesis of elansolids B1 and B2

2017 ◽  
Vol 13 ◽  
pp. 1280-1287 ◽  
Author(s):  
Liang-Liang Wang ◽  
Andreas Kirschning
Keyword(s):  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Total Synthesis ◽  
Second Generation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Gram Positive Bacteria ◽  
Cross Coupling Reaction ◽  
Gliding Bacterium ◽  
Coupling Sequence

The elansolids A1–A3, B1, and B2 are secondary metabolites formed by the gliding bacterium Chitinophaga sancti. They show antibacterial activity against Gram-positive bacteria. A second generation total synthesis of the antibiotic elansolid B1 (2) and the first synthesis of elansolid B2 (3) are reported. In contrast to previous work, the (Z,E,Z)-triene at C10–C15 was assembled by using an optimized C–C cross-coupling sequence with a Suzuki cross-coupling reaction as key step.

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