Solvent-Free Non-Covalent Organocatalysis: Enantioselective Addition of Nitroalkanes to Alkylideneindolenines as a Flexible Gateway to Optically Active Tryptamine Derivatives

2012 ◽  
Vol 354 (7) ◽  
pp. 1373-1380 ◽  
Author(s):  
Mariafrancesca Fochi ◽  
Lucia Gramigna ◽  
Andrea Mazzanti ◽  
Sara Duce ◽  
Stefano Fantini ◽  
...  
Keyword(s):  
Optically Active ◽  
Solvent Free ◽  
Enantioselective Addition

ChemInform Abstract: Solvent-Free Non-Covalent Organocatalysis: Enantioselective Addition of Nitroalkanes to Alkylideneindolenines as a Flexible Gateway to Optically Active Tryptamine Derivatives.

ChemInform ◽  
2012 ◽  
Vol 43 (37) ◽  
pp. no-no
Author(s):  
Mariafrancesca Fochi ◽  
Lucia Gramigna ◽  
Andrea Mazzanti ◽  
Sara Duce ◽  
Stefano Fantini ◽  
...  
Keyword(s):  
Optically Active ◽  
Solvent Free ◽  
Enantioselective Addition

Rapid and Efficient Synthesis of Optically Active Pyrazoles under Solvent-Free Conditions.

ChemInform ◽  
2005 ◽  
Vol 36 (8) ◽  
Author(s):  
J. S. Yadav ◽  
B. V. S. Reddy ◽  
G. Satheesh ◽  
P. Naga Lakshmi ◽  
S. Kiran Kumar ◽  
...  
Keyword(s):  
Optically Active ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Solvent Free Conditions

Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters

Synlett ◽  
2019 ◽  
Vol 30 (14) ◽  
pp. 1693-1697
Author(s):  
Diao Chen ◽  
Jian-Guo Liu ◽  
Xu Zhang ◽  
Ming-Hua Xu
Keyword(s):  
Catalytic System ◽  
Mandelic Acid ◽  
Optically Active ◽  
Antiplatelet Drug ◽  
Reaction Conditions ◽  
Formal Synthesis ◽  
Arylboronic Acids ◽  
Synthetic Utility ◽  
Enantioselective Addition ◽  
Acid Esters

A rhodium-catalyzed enantioselective addition of glyoxylates to arylboronic acids promoted by a simple chiral sulfinamide-based olefin ligand under mild reaction conditions is described. The reaction provides access to a variety of optically active substituted mandelic acid esters in good yields with up to 83% ee. The catalytic system is also applicable to pyruvate addition. The synthetic utility of this method is highlighted by a formal synthesis of the antiplatelet drug clopidogrel.

Rapid and efficient synthesis of optically active pyrazoles under solvent-free conditions

2004 ◽  
Vol 45 (46) ◽  
pp. 8587-8590 ◽  
Author(s):  
J.S. Yadav ◽  
B.V.S. Reddy ◽  
G. Satheesh ◽  
P. Naga Lakshmi ◽  
S. Kiran Kumar ◽  
...  
Keyword(s):  
Optically Active ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Solvent Free Conditions
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