New Polymer-Supported Catalysts for the Asymmetric Transfer Hydrogenation of Acetophenone in Water - Kinetic and Mechanistic Investigations

2011 ◽  
Vol 353 (8) ◽  
pp. 1335-1344 ◽  
Author(s):  
Jonas Dimroth ◽  
Uwe Schedler ◽  
Juliane Keilitz ◽  
Rainer Haag ◽  
Reinhard Schomäcker
Keyword(s):  
Supported Catalysts ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Polymer Supported ◽  
Mechanistic Investigations

Asymmetric Transfer Hydrogenation of Ketones with a Polymer-Supported Chiral Diamine.

ChemInform ◽  
2004 ◽  
Vol 35 (19) ◽  
Author(s):  
Xiaoguang Li ◽  
Weiping Chen ◽  
William Hems ◽  
Frank King ◽  
Jianliang Xiao
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Diamine ◽  
Polymer Supported

Asymmetric transfer hydrogenation of ketones with a polymer-supported chiral diamine

2004 ◽  
Vol 45 (5) ◽  
pp. 951-953 ◽  
Author(s):  
Xiaoguang Li ◽  
Weiping Chen ◽  
William Hems ◽  
Frank King ◽  
Jianliang Xiao
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Diamine ◽  
Polymer Supported

scholarly journals Design of Iridium N-Heterocyclic Carbene Amino Acid Catalysts for Asymmetric Transfer Hydrogenation of Aryl Ketones

Catalysts ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 671
Author(s):  
Chad M. Bernier ◽  
Joseph S. Merola
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Enantiomeric Excess ◽  
Transfer Hydrogenation ◽  
Acid Catalysts ◽  
Asymmetric Transfer Hydrogenation ◽  
Reaction Conditions ◽  
Chiral Complexes ◽  
Acetophenone Derivatives ◽  
Aryl Ketones

A series of chiral complexes of the form Ir(NHC)2(aa)(H)(X) (NHC = N-heterocyclic carbene, aa = chelated amino acid, X = halide) was synthesized by oxidative addition of -amino acids to iridium(I) bis-NHC compounds and screened for asymmetric transfer hydrogenation of ketones. Following optimization of the reaction conditions, NHC, and amino acid ligands, high enantioselectivity was achieved when employing the Ir(IMe)2(l-Pro)(H)(I) catalyst (IMe = 1,3-dimethylimidazol-2-ylidene), which asymmetrically reduces a range of acetophenone derivatives in up to 95% enantiomeric excess.

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