4-Aminothiourea Prolinoltert-Butyldiphenylsilyl Ether: A Chiral Secondary Amine-Thiourea as Organocatalyst for Enantioselectiveanti-Mannich Reactions

2009 ◽  
Vol 351 (14-15) ◽  
pp. 2288-2294 ◽  
Author(s):  
Hui Zhang ◽  
Yongming Chuan ◽  
Zhengyu Li ◽  
Yungui Peng
Keyword(s):  
Secondary Amine ◽  
Mannich Reactions

scholarly journals Recent advances and prospects in the Zn-catalysed Mannich reaction

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9098-9111
Author(s):  
Salahudeen Shamna ◽  
C. M. A. Afsina ◽  
Rose Mary Philip ◽  
Gopinathan Anilkumar
Keyword(s):  
Carbonyl Compound ◽  
Secondary Amine ◽  
Mannich Reaction ◽  
Mannich Base ◽  
Mannich Reactions ◽  
Recent Advances ◽  
Primary Secondary Amine

Amino alkylation of an acidic α-proton of a carbonyl by formaldehyde and a primary/secondary amine or ammonia, affording a β-amino-carbonyl compound also known as a Mannich base is a valuable reaction. We focus on recent advances in Zn catalysed Mannich reactions.

Diastereoselectivity in a cyclic secondary amine catalyzed asymmetric Mannich reaction: a model rationalization from DFT studies

2018 ◽  
Vol 5 (14) ◽  
pp. 2148-2157 ◽  
Author(s):  
Siwei Shu ◽  
Zhao Liu ◽  
Yukui Li ◽  
Zhuofeng Ke ◽  
Yan Liu
Keyword(s):  
Secondary Amine ◽  
Mannich Reaction ◽  
Dft Studies ◽  
Detailed Structure ◽  
Mannich Reactions

DFT studies revealed the detailed structure stereoselectivity relationship for cyclic secondary amine catalyzed asymmetric Mannich reactions.

Highly Diastereo- and Enantioselective Mannich Reactions of Synthetically Flexible Ketimines with Secondary Amine Organocatalysts

2011 ◽  
Vol 124 (5) ◽  
pp. 1217-1220 ◽  
Author(s):  
Taichi Kano ◽  
Sunhwa Song ◽  
Yasushi Kubota ◽  
Keiji Maruoka
Keyword(s):  
Secondary Amine ◽  
Mannich Reactions

CONJUGATED OESTROGENS. I

1963 ◽  
Vol 43 (3) ◽  
pp. 345-360 ◽  
Author(s):  
Stanley Kushinsky ◽  
Jane (Wu) Tang
Keyword(s):  
Molecular Weight ◽  
Formic Acid ◽  
Ethyl Acetate ◽  
High Molecular Weight ◽  
Secondary Amine ◽  
Aqueous Ammonia ◽  
Organic Solution ◽  
Extraneous Material

ABSTRACT A convenient and mild procedure is described in this paper whereby free and conjugated oestrogens may be extracted from urine. The extracts containing approximately 90 per cent of the oestrogens are devoid of most of the extraneous material and may be reduced in volume to less than 1/15 of that of the urine. The procedure consists of the following steps: (1) a 10 per cent (v/v) solution of a high molecular weight secondary amine (Amberlite LA-2, Rohm and Haas) in ethyl acetate is washed with formic acid and water, (2) the oestrogens in urine (acidified to pH 2 or 3 with H2SO4) are extracted with the LA-2 solution, (3) the oestrogen fraction is back-extracted from the organic solution with dilute aqueous ammonia.

Regio-, Stereo- and Enantioselective α-Addition of Carbonyl Nucleo-philes to Allenamides Catalyzed by a Synergistic Copper/Enamine System

2020 ◽  
Author(s):  
Rémi Blieck ◽  
Sebastien Lemouzy ◽  
Marc Taillefer ◽  
Florian Monnier
Keyword(s):  
Catalytic System ◽  
Secondary Amine ◽  
Primary Amine ◽  
Synergistic Catalysis ◽  
Enantioselective Addition ◽  
Amine Catalysts

A dual copper/enamine catalytic system is found to enable an intermolecular enantioselective α-addition of various carbonyl nucleophiles to allenamides. Secondary amine catalysts allowed the highly enantioselective addition of aldehydes, while using primary amine catalysts led to the enantioselective addition of ketoester nucleophiles. The process was found to be highly regio-, stereo- and enantio-selective and represented the first allene hydrofunctionalization using an synergistic catalysis involving copper

Advances on Asymmetric Organocatalyzed Mannich Reactions in Aqueous and Non-aqueous Media

2016 ◽  
Vol 3 (2) ◽  
pp. 133-160 ◽  
Author(s):  
Ayndrila Ghosh ◽  
Sudipto Bhowmick ◽  
Anirban Mondal ◽  
Harekrishna Garai ◽  
Kartick C. Bhowmick
Keyword(s):  
Aqueous Media ◽  
Mannich Reactions
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