Stereoselective Synthesis of Three Isomers of tert-Butyl 5-Hydroxy-4-methyl-3-oxohexanoate through Alcohol Dehydrogenase-Catalyzed Dynamic Kinetic Resolution

2009 ◽  
Vol 351 (1-2) ◽  
pp. 253-259 ◽  
Author(s):  
Steffen Lüdeke ◽  
Michael Richter ◽  
Michael Müller
Keyword(s):  
Alcohol Dehydrogenase ◽  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Dynamic Kinetic Resolution ◽  
Tert Butyl

Stereoselective Synthesis ofanti-β-Hydroxy-α-amino Acids through Dynamic Kinetic Resolution

2004 ◽  
Vol 116 (7) ◽  
pp. 900-902 ◽  
Author(s):  
Kazuishi Makino ◽  
Takayuki Goto ◽  
Yasuhiro Hiroki ◽  
Yasumasa Hamada
Keyword(s):  
Amino Acids ◽  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Dynamic Kinetic Resolution

Stereoselective Synthesis ofanti-β-Hydroxy-α-amino Acids through Dynamic Kinetic Resolution

2004 ◽  
Vol 43 (7) ◽  
pp. 882-884 ◽  
Author(s):  
Kazuishi Makino ◽  
Takayuki Goto ◽  
Yasuhiro Hiroki ◽  
Yasumasa Hamada
Keyword(s):  
Amino Acids ◽  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Dynamic Kinetic Resolution

scholarly journals Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions

2019 ◽  
Vol 9 (15) ◽  
pp. 4083-4090 ◽  
Author(s):  
Ángela Mourelle-Insua ◽  
Daniel Méndez-Sánchez ◽  
James L. Galman ◽  
Iustina Slabu ◽  
Nicholas J. Turner ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Efficient Synthesis ◽  
Dynamic Kinetic Resolution ◽  
Amino Amides ◽  
Kinetic Resolutions

A transaminase-catalyzed dynamic kinetic resolution is described for the stereoselective synthesis of a series of α-alkyl-β-amino amides.

Kinetic Resolution, Dynamic Kinetic Resolution and Asymmetric Desymmetrization by N-Heterocyclic Carbene Catalysis

Synthesis ◽  
2019 ◽  
Vol 51 (09) ◽  
pp. 1871-1891 ◽  
Author(s):  
Carmela De Risi ◽  
Olga Bortolini ◽  
Graziano Di Carmine ◽  
Daniele Ragno ◽  
Alessandro Massi
Keyword(s):  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Short Review ◽  
Heterocyclic Carbenes ◽  
Dynamic Kinetic Resolution ◽  
Asymmetric Transformations ◽  
Significant Interest ◽  
Stetter Reactions

N-Heterocyclic carbenes (NHCs) are now well-established organocatalysts for a large number of asymmetric and non-asymmetric transformations. In the last 15 years, there has been significant interest in using NHCs in kinetic resolution (KR), dynamic kinetic resolution (DKR) and asymmetric desymmetrization reactions for the stereoselective synthesis of enantioenriched compounds, with diverse substrates and activation modes being adopted to this end. This short review brings into focus the progress made on NHC-catalyzed KR, DKR, and asymmetric desymmetrization from 2004 until December 2018. The literature discussed in this article is classified on the basis of the type of reaction involving the NHC catalyst.1 Introduction2 Acylation Strategies2.1 O-Acylation2.2 N-Acylation2.3 C-Acylation3 Aldol-Acylation Processes4 Benzoin Reactions5 Stetter Reactions6 Miscellaneous Approaches7 Conclusion

Stereoselective Synthesis of anti-β-Hydroxy-α-amino Acids Through Dynamic Kinetic Resolution.

ChemInform ◽  
2004 ◽  
Vol 35 (22) ◽  
Author(s):  
Kazuishi Makino ◽  
Takayuki Goto ◽  
Yasuhiro Hiroki ◽  
Yasumasa Hamada
Keyword(s):  
Amino Acids ◽  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Dynamic Kinetic Resolution

scholarly journals Dynamic kinetic resolution of tert-butyl 4-methyl-3,5-dioxohexanoate through enzymatic reduction

2001 ◽  
pp. 57-58 ◽  
Author(s):  
Aiguo Ji ◽  
Michael Wolberg ◽  
Christian Wandrey ◽  
Michael Müller ◽  
Werner Hummel
Keyword(s):  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Tert Butyl ◽  
Enzymatic Reduction
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