Practical Synthesis of (E)-α,β-Unsaturated Carboxylic Acids Using a One-Pot Hydroformylation/Decarboxylative Knoevenagel Reaction Sequence

2008 ◽  
Vol 350 (7-8) ◽  
pp. 989-994 ◽  
Author(s):  
Susanne T. Kemme ◽  
Tomáš Šmejkal ◽  
Bernhard Breit
Keyword(s):  
Carboxylic Acids ◽  
Knoevenagel Reaction ◽  
Reaction Sequence ◽  
One Pot ◽  
Unsaturated Carboxylic Acids ◽  
Practical Synthesis

Practical Synthesis of (Z)-α,β-Unsaturated Nitriles via a One-Pot Sequential Hydroformylation/Knoevenagel Reaction

2021 ◽  
Vol 86 (21) ◽  
pp. 15413-15422
Author(s):  
Yanxin Jiang ◽  
Chao Li ◽  
Songbai Tang ◽  
Shaokun Tao ◽  
Maolin Yuan ◽  
...  
Keyword(s):  
Knoevenagel Reaction ◽  
One Pot ◽  
Practical Synthesis

Stable carboxylic acid derivatized alkoxy silanes

2015 ◽  
Vol 51 (12) ◽  
pp. 2339-2341 ◽  
Author(s):  
A. Feinle ◽  
S. Flaig ◽  
M. Puchberger ◽  
U. Schubert ◽  
N. Hüsing
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
One Pot ◽  
Hydrosilylation Reaction ◽  
Unsaturated Carboxylic Acids ◽  
Organofunctional Silanes ◽  
Alkoxy Groups

A convenient and straightforward one-pot hydrosilylation reaction of different unsaturated carboxylic acids with trialkoxysilanes in the presence of catalytic amounts of platinum(iv) dioxide resulted in excellent yields in organofunctional silanes combining carboxy- and alkoxy groups within one molecule.

Practical Synthesis of 2'-5'-Linked Oligoadenylates (2-5A Oligomers)

1992 ◽  
Vol 45 (1) ◽  
pp. 205 ◽  
Author(s):  
R Noyori ◽  
M Uchiyama ◽  
T Nobori ◽  
M Hirose ◽  
Y Hayakawa
Keyword(s):  
Ethyl Acetate ◽  
Second Order ◽  
High Yield ◽  
Similar Reaction ◽  
Reaction Sequence ◽  
Facile Synthesis ◽  
One Pot ◽  
Subsequent Oxidation ◽  
Practical Synthesis ◽  
Related Compounds

A general, facile synthesis of 2'-5'-linked oligonucleotides (2-5A oligomers ) has been achieved based on the second-order regioselective protection of adenosine, one-pot formation of the 2'5' internucleotide linkage, and O-selective phosphorylation of N-unblocked nucleosides. Standard t- butyldimethylsilylation of 5'-O-p-methoxytrityladenosine followed by careful recrystallization from a mixture of triethylamine , methanol, ethyl acetate and ether (4 : 4 : 5 : 100 v/v) gives the 3',5'-di-O-protected adenosine in high yield. Magnesium alkoxide -mediated condensation of the 2'-O-free adenosine with o-chlorophenyl p-nitrophenyl phosphorochloridate followed by 2',3'-di-O-t-butyldimethylsilyladenosine produces the N-free and fully O-protected adenylyl (2'-5')adenosine. The resulting adenylyl dimer, after removal of the 5'-O-trityl protector, is elongated to the protected trimeric compound through a similar reaction sequence. Deprotection of the product furnishes the 2-5A core. Condensation of the 5?-0-detritylated core and bis (2,2,2-trichloroethyl) phosphorochloridite assisted by 2,6-lutidine and subsequent oxidation with aqueous iodine produces, after deblocking, 2-5A 5'-monophosphate (p5'A2'p5'pA2'p5'A). The 2-5A 5'-monophosphate is converted into 2-5A 5'-triphosphate (ppp5'A2'p5'A2'p5'A) by reaction with N,N'-carbonyldiimidazole in the presence of triethylamine followed by tributylammonium diphosphate. This procedure allows ready synthesis of 2-5A oligomers and related compounds on a multigram scale.

New Convenient One-Pot Methods of Conversion of Alkynes to Cyclobutenediones or α,β-Unsaturated Carboxylic Acids Using Novel Reactive Iron Carbonyl Reagents

1998 ◽  
Vol 63 (15) ◽  
pp. 4930-4935 ◽  
Author(s):  
Mariappan Periasamy ◽  
Chellappan Rameshkumar ◽  
Ukkiramapandian Radhakrishnan ◽  
Jean-Jacques Brunet
Keyword(s):  
Carboxylic Acids ◽  
Iron Carbonyl ◽  
One Pot ◽  
Reactive Iron ◽  
Unsaturated Carboxylic Acids
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