scholarly journals In Situ Fine‐Tuning of Microfluidic Chips by Swelling and Its Application to Droplet Microfluidics

2019 ◽  
Vol 4 (8) ◽  
pp. 1900232
Author(s):  
Juan H. González‐Estefan ◽  
Mathieu Gonidec ◽  
Thi Thiet Vu ◽  
Nathalie Daro ◽  
Guillaume Chastanet
Keyword(s):  
Droplet Microfluidics ◽  
Fine Tuning ◽  
Microfluidic Chips

Production of Fluoropolymer Microchips for Droplet Microfluidics and DNA Amplification

2010 ◽  
Author(s):  
Stefano Begolo ◽  
Guillaume Colas ◽  
Laurent Malaquin ◽  
Jean-Louis Viovy
Keyword(s):  
Low Temperatures ◽  
Dna Amplification ◽  
Droplet Microfluidics ◽  
Cross Contamination ◽  
Uniform Pressure ◽  
Microfluidic Chips ◽  
Fabrication Technique ◽  
Flexible Membrane ◽  
Low Surface Energy ◽  
Solvent Bonding

In this paper we present a novel fabrication technique for production of monolithic microfluidic chips made from a fluoropolymer (Dyneon THV). This material retains numerous properties of commonly used fluoropolymers (low surface energy and compatibility with chemicals such as organic solvents or fluorinated oil), and is easily processable at relatively low temperatures (lower than 180°C). We used hot embossing to mold microstructures on flat sheets of this polymer. The microchips are sealed through a combination of thermal and solvent bonding by applying uniform pressure with a flexible membrane. These closed channels can be used for the production and circulation of aqueous droplets in fluorinated oil. This droplet microfluidic configuration is suitable for DNA amplification since it avoids cross contamination between adjacent droplets.

scholarly journals The Mediterranean Ocean Colour Level 3 Operational Multi-Sensor Processing

2018 ◽  
Author(s):  
Gianluca Volpe ◽  
Simone Colella ◽  
Vittorio Brando ◽  
Vega Forneris ◽  
Flavio La Padula ◽  
...  
Keyword(s):  
Fine Tuning ◽  
Ocean Colour ◽  
Basin Scale ◽  
Sensor Processing ◽  
Level 3 ◽  
The Mediterranean ◽  
Set Up ◽  
Marine Environment Monitoring ◽  
Monitoring Service

Abstract. This work describes the main processing steps operationally performed to enable single ocean colour sensors to enter the multi-sensor chain for the Mediterranean Sea of Ocean Colour Thematic Assembling Centre. Here, the multi-sensor chain takes care of reducing the inter-sensor bias before data from different sensors are merged together. The basin-scale in situ bio-optical dataset is used both to fine-tuning the algorithms for the retrieval of phytoplankton chlorophyll and attenuation coefficient of light, Kd, and to assess the uncertainty associated with them. The satellite multi-sensor remote sensing Reflectance spectra better agree with the in situ observations than that of the single sensors, and are comparable with the ESA-OC-CCI multi-sensor product, highlighting the importance of reducing the inter-sensor bias. The Mediterranean near-real-time multi-sensor processing chain has been set up and is operational in the framework of the Copernicus Marine Environment Monitoring Service.

Catalytic Appel reactions

2012 ◽  
Vol 85 (4) ◽  
pp. 817-828 ◽  
Author(s):  
Henri A. van Kalkeren ◽  
Floris L. van Delft ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Organic Compounds ◽  
Modern Synthesis ◽  
Fine Tuning ◽  
Phosphine Oxides ◽  
In Situ Reduction ◽  
Significant Progress ◽  
The Right ◽  
Organophosphorus Chemistry

Organophosphorus chemistry plays a key role in the modern synthesis of organic compounds. The formation of phosphine oxides from phosphines often drives reactions to completion. However, these oxides also result in waste and purification issues. Organophosphorus catalysis aims to address these problems, and in this paper we present our progress in developing and utilizing new organophosphorus catalysts. More specifically, the in situ reduction of a range of cyclic phosphine oxides was explored, leading to the development of dibenzophospholes as new organophosphorus catalysts and the application thereof in the phosphorus-mediated substitution of alcohols by halides, which is also known as the Appel reaction. We show that the electronic fine-tuning of the catalyst is crucial for the success of the reaction and that the development of reactions using the in situ reduction protocol all depends on finding the right balance in the reactivities of the reaction components. This balance has been successfully found for the bromination of alcohols, and significant progress has been made for the chlorination reactions.

Fine Tuning of the Van Nuys Prognostic Index (VNPI) 2003 by Integrating the Genomic Grade Index (GGI): New Tools for Ductal Carcinoma In Situ (DCIS)

2011 ◽  
Vol 17 (4) ◽  
pp. 343-351 ◽  
Author(s):  
Sevilay Altintas ◽  
Jerome Toussaint ◽  
Virginie Durbecq ◽  
Kathleen Lambein ◽  
Manon T. Huizing ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Prognostic Index ◽  
Fine Tuning ◽  
Genomic Grade Index ◽  
Van Nuys Prognostic Index ◽  
Grade Index

Vertical sidewall electrodes monolithically integrated into 3D glass microfluidic chips using water-assisted femtosecond-laser fabrication for in situ control of electrotaxis

RSC Advances ◽  
2015 ◽  
Vol 5 (31) ◽  
pp. 24072-24080 ◽  
Author(s):  
Jian Xu ◽  
Dong Wu ◽  
Joanna Y. Ip ◽  
Katsumi Midorikawa ◽  
Koji Sugioka
Keyword(s):  
Femtosecond Laser ◽  
Microfluidic Chips ◽  
Vertical Sidewall ◽  
Laser Fabrication ◽  
Monolithically Integrated ◽  
In Situ Control ◽  
High Flexibility

Novel sidewall metal patterning with high flexibility enables facile integration of vertical electrodes in microchannels for in situ control of electrotaxis.

Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns’ urine samples

The Analyst ◽  
2016 ◽  
Vol 141 (21) ◽  
pp. 6002-6007 ◽  
Author(s):  
Laura García-Carmona ◽  
Daniel Rojas ◽  
María Cristina González ◽  
Alberto Escarpa
Keyword(s):  
Urine Samples ◽  
Microfluidic Chips ◽  
Metallic Oxide ◽  
Fast Detection ◽  
First Time

This work describes for the first time the coupling of microfluidic chips (MC) to electrosynthetized silver metallic oxide clusters (AgMOCs).

In situ fine tuning of bendable soft x-ray mirrors using a lateral shearing interferometer

2013 ◽  
Vol 710 ◽  
pp. 82-86 ◽  
Author(s):  
Daniel J. Merthe ◽  
Kenneth A. Goldberg ◽  
Valeriy V. Yashchuk ◽  
Wayne R. McKinney ◽  
Richard Celestre ◽  
...  
Keyword(s):  
Fine Tuning ◽  
X Ray ◽  
Lateral Shearing Interferometer ◽  
Lateral Shearing

scholarly journals In situ observation of shrinking and swelling of normal and compression Chinese fir wood at the tissue, cell and cell wall level

2021 ◽  
Author(s):  
Tianyi Zhan ◽  
Jianxiong Lyu ◽  
Michaela Eder
Keyword(s):  
Cell Wall ◽  
Compression Wood ◽  
Chinese Fir ◽  
Fine Tuning ◽  
Tissue Cell ◽  
In Situ Observation ◽  
Normal Wood ◽  
Moisture Variation ◽  
Hierarchical Levels

AbstractThe shrinking and swelling of wood due to moisture changes are intrinsic material properties that control and limit the use of wood in many applications. Herein, hygroscopic deformations of normal and compression wood of Chinese fir (Cunninghamia lanceolata [Lamb.] Hook.) were measured during desorption and absorption processes. The dimensional changes were observed in situ by an environmental scanning electron microscope and analyzed at different hierarchical levels (tissue, cell and cell wall). The relationship between moisture variation and hygroscopic deformation was measured. During initial desorption periods from 95 to 90 or 75% RH, an expansion of the lumen and a shrinkage of the cell wall were observed, revealing a non-uniform and directional deformation of single wood cells. The variation of shrinking or swelling at different hierarchical levels (tissue, cell and cell wall) indicates that the hygroscopic middle lamella plays a role in the deformation at the tissue level. Higher microfibril angles and helical cavities on the cell wall in compression wood correlate with a lower shrinking/swelling ratio. Normal wood showed a more pronounced swelling hysteresis than compression wood, while the sorption hysteresis was almost the same for both wood types. This finding is helpful to elucidate effects of micro- and ultrastructure on sorption. The present findings suggest that the sophisticated system of wood has the abilities to adjust the hygroscopic deformations by fine-tuning its hierarchical structures.

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