Target Reprogramming Lysosomes of CD8+ T Cells by a Mineralized Metal–Organic Framework for Cancer Immunotherapy

2021 ◽  
pp. 2100616
Author(s):  
Qin Zhao ◽  
Zijian Gong ◽  
Zhihao Li ◽  
Jinyang Wang ◽  
Jinglun Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Cancer Immunotherapy ◽  
Cd8 T Cells ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Nanoscale Metal–Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy

2020 ◽  
Vol 142 (29) ◽  
pp. 12579-12584 ◽  
Author(s):  
Kaiyuan Ni ◽  
Taokun Luo ◽  
August Culbert ◽  
Michael Kaufmann ◽  
Xiaomin Jiang ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Immune-regulating bimetallic metal-organic framework nanoparticles designed for cancer immunotherapy

Biomaterials ◽  
2021 ◽  
pp. 121261
Author(s):  
Zan Dai ◽  
Qiaoyun Wang ◽  
Jie Tang ◽  
Min Wu ◽  
Haoze Li ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

2018 ◽  
Vol 140 (17) ◽  
pp. 5670-5673 ◽  
Author(s):  
Guangxu Lan ◽  
Kaiyuan Ni ◽  
Ziwan Xu ◽  
Samuel S. Veroneau ◽  
Yang Song ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Immunotherapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy

Chem ◽  
2019 ◽  
Vol 5 (7) ◽  
pp. 1892-1913 ◽  
Author(s):  
Kaiyuan Ni ◽  
Theint Aung ◽  
Shuyi Li ◽  
Nina Fatuzzo ◽  
Xingjie Liang ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Metal Organic Framework ◽  
Radical Therapy ◽  
Metal Organic ◽  
Organic Framework

Bioinspired Engineering of a Bacterium‐Like Metal–Organic Framework for Cancer Immunotherapy

2020 ◽  
Vol 30 (42) ◽  
pp. 2003764 ◽  
Author(s):  
Po‐Ming Chen ◽  
Wen‐Yu Pan ◽  
Yang‐Bao Miao ◽  
Yu‐Miao Liu ◽  
Po‐Kai Luo ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Magnetic Ordering via Itinerant Ferromagnetism in a Metal-Organic Framework

2020 ◽  
Author(s):  
Jesse Park ◽  
Brianna Collins ◽  
Lucy Darago ◽  
Tomce Runcevski ◽  
Michael Aubrey ◽  
...  
Keyword(s):  
Charge Transport ◽  
Magnetic Order ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Magnetic Ordering ◽  
Double Exchange ◽  
Itinerant Ferromagnetism ◽  
Organic Solids ◽  
Metal Organic ◽  
Organic Framework

<b>Materials that combine magnetic order with other desirable physical attributes offer to revolutionize our energy landscape. Indeed, such materials could find transformative applications in spintronics, quantum sensing, low-density magnets, and gas separations. As a result, efforts to design multifunctional magnetic materials have recently moved beyond traditional solid-state materials to metal–organic solids. Among these, metal–organic frameworks in particular bear structures that offer intrinsic porosity, vast chemical and structural programmability, and tunability of electronic properties. Nevertheless, magnetic order within metal–organic frameworks has generally been limited to low temperatures, owing largely to challenges in creating strong magnetic exchange in extended metal–organic solids. Here, we employ the phenomenon of itinerant ferromagnetism to realize magnetic ordering at <i>T</i><sub>C</sub> = 225 K in a mixed-valence chromium(II/III) triazolate compound, representing the highest ferromagnetic ordering temperature yet observed in a metal–organic framework. The itinerant ferromagnetism is shown to proceed via a double-exchange mechanism, the first such observation in any metal–organic material. Critically, this mechanism results in variable-temperature conductivity with barrierless charge transport below <i>T</i><sub>C</sub> and a large negative magnetoresistance of 23% at 5 K. These observations suggest applications for double-exchange-based coordination solids in the emergent fields of magnetoelectrics and spintronics. Taken together, the insights gleaned from these results are expected to provide a blueprint for the design and synthesis of porous materials with synergistic high-temperature magnetic and charge transport properties. </b>

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