Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery

2020 ◽  
Vol 32 (11) ◽  
pp. 1907365 ◽  
Author(s):  
Rui Tian ◽  
Huilong Ma ◽  
Shoujun Zhu ◽  
Joseph Lau ◽  
Rui Ma ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Detection ◽  
Guided Surgery

scholarly journals In Vivo Imaging: Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery (Adv. Mater. 11/2020)

2020 ◽  
Vol 32 (11) ◽  
pp. 2070086
Author(s):  
Rui Tian ◽  
Huilong Ma ◽  
Shoujun Zhu ◽  
Joseph Lau ◽  
Rui Ma ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Detection ◽  
In Vivo Imaging ◽  
Guided Surgery

scholarly journals Prostate Lymphoscintigraphy and Radio-Guided Surgery for Sentinel Lymph Node Identification in Prostate Cancer

2003 ◽  
Vol 70 (4) ◽  
pp. 303-310 ◽  
Author(s):  
Friedhelm Wawroschek ◽  
Harry Vogt ◽  
Hermann Wengenmair ◽  
Dorothea Weckermann ◽  
Michael Hamm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Guided Surgery ◽  
Sentinel Lymph Node Identification

Detection of Sentinel Nodes by Lymphoscintigraphy and Gamma Probe Guided Surgery in Vulvar Neoplasia

2000 ◽  
Vol 86 (4) ◽  
pp. 359-363 ◽  
Author(s):  
Mario Sideri ◽  
Concetta De Cicco ◽  
Angelo Maggioni ◽  
Nicoletta Colombo ◽  
Luca Bocciolone ◽  
...  
Keyword(s):  
Lymph Node ◽  
Vulvar Cancer ◽  
Gamma Probe ◽  
Human Albumin ◽  
Lymph Node Status ◽  
Breast Cancer Patients ◽  
Node Dissection ◽  
Sentinel Nodes ◽  
Guided Surgery ◽  
Pathologic Evaluation

Background Pathologic lymph node status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Intraoperative lymphoscintigraphy associated with gamma detecting probe-guided surgery has proved to be reliable in the detection of sentinel node (SN) involvement in melanoma and breast cancer patients. The present study evaluates the feasibility of the surgical identification of inguinal sentinel nodes using lymphoscintigraphy and a gamma detecting probe in patients with early vulvar cancer. Methods Technetium-99-labeled colloid human albumin was administered perilesionally in 44 patients. Twenty patients had T1 and 23 had T2 invasive epidermoid vulvar cancer; one patient had a lower-third vaginal cancer. An intraoperative gamma detecting probe was used to identify SNs during surgery. Complete inguinofemoral node dissection was subsequently performed. SNs underwent separate pathologic evaluation. Results A total of 77 groins were dissected in 44 patients. SNs were identified in all the studied groins. Thirteen cases had positive nodes: the SN was positive in all of them; in 10 cases the SN was the only positive node. Thirty-one patients showed negative SNs: all of them were negative for lymph node metastasis. Conclusions Lymphoscintigraphy and SN biopsy under gamma detecting probe guidance proved to be an easy and reliable method for detection of SNs in early vulvar cancer. If these preliminary data will be confirmed, the technique would represent a real progress towards less aggressive treatment in patients with vulvar cancer.

scholarly journals Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

2017 ◽  
Vol 8 (5) ◽  
pp. 3489-3493 ◽  
Author(s):  
Yao Sun ◽  
Mingmin Ding ◽  
Xiaodong Zeng ◽  
Yuling Xiao ◽  
Huaping Wu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Small Molecule ◽  
Tumor Imaging ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Bright Emission

This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores forin vivotumor imaging and NIR-II image-guided sentinel lymph node surgery.

692 Radio-guided surgery: Our experience in sentinel lymph node removal in prostate cancer

2013 ◽  
Vol 12 (1) ◽  
pp. e692
Author(s):  
M. Grasso ◽  
S. Blanco ◽  
A.A.C. Grasso ◽  
G. Bovo ◽  
A. Crespi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Guided Surgery ◽  
Node Removal

RESIDUAL LYMPH NODE METASTASIS IN STAGE 4 NEUROBLASTOMA—ADVANTAGE OF RADIO-GUIDED SURGERY?

2010 ◽  
Vol 27 (6) ◽  
pp. 471-475
Author(s):  
Robin Wachowiak ◽  
Holger Till ◽  
Roman Metzger ◽  
Uta Bierbach ◽  
Thorsten Simon ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Guided Surgery ◽  
Node Metastasis ◽  
Stage 4

scholarly journals Comprehensive Review of Fluorescence Applications in Gynecology

2021 ◽  
Vol 10 (19) ◽  
pp. 4387
Author(s):  
Joanna Polom ◽  
Leszek Kalinowski ◽  
Michele Diana ◽  
Manish Chand ◽  
Carmela Caballero ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Safety Issues ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Margin Detection ◽  
New Applications ◽  
Improve Patient

Since the introduction of indocyanine green (ICG) as a fluorophore in near-infrared imaging, fluorescence visualization has become an essential tool in many fields of surgery. In the field of gynecology, recent new applications have been proposed and found their place in clinical practice. Different applications in gynecology were investigated, subcategorized, and overviewed concerning surgical applications and available dyes. Specific applications in which fluorescence-guided surgery was implemented in gynecology are described in this manuscript—namely, sentinel node biopsy, mesometrium visualization, angiography of different organs, safety issues in pregnant women, ureters visualization, detection of peritoneal metastases, targeted fluorophores for cancer detection, fluorescent contamination hysterectomy, lymphography for lower limb lymphedema prevention, tumor margin detection, endometriosis, and metastases mapping. With evolving technology, further innovative research on the new applications of fluorescence visualization in cancer surgery may help to establish these techniques as standards of high-quality surgery in gynecology. However, more investigations are necessary in order to assess if these innovative tools can also be effective to improve patient outcomes and quality of life in different gynecologic malignancies.

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