Pretreated Macrophage-Membrane-Coated Gold Nanocages for Precise Drug Delivery for Treatment of Bacterial Infections

2018 ◽  
Vol 30 (46) ◽  
pp. 1804023 ◽  
Author(s):  
Can Wang ◽  
Yulan Wang ◽  
Lingling Zhang ◽  
Richard J. Miron ◽  
Jianfei Liang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Gold Nanocages ◽  
Macrophage Membrane

Amoxicilin and Clavulanic Acid Intercaled Nanostructures for Dentistry Uses

2019 ◽  
Vol 56 (2) ◽  
pp. 396-398
Author(s):  
Georgeta Zegan ◽  
Daniela Anistoroaei ◽  
Elena Mihaela Carausu ◽  
Eduard Radu Cernei ◽  
loredana Golovcencu
Keyword(s):  
Drug Delivery ◽  
Clavulanic Acid ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Intracellular Transport ◽  
Oral Treatment ◽  
Chitosan Nanoparticles ◽  
Well Being ◽  
Cell Penetrating ◽  
Novel Drug

Amoxicillin and clavulanic acid are two of the most commonly prescribed antibacterial worldwide for treating oral infectious diseases. Oral health is of big importance for well-being and general health. A few novel drug delivery systems were designed for oral treatment and prophylaxis of different diseases in the oral cavity. This work focused on the latest drug delivery development of the most common oral pathologies, namely, periodontitis, oral mucosal infections, dental caries and oral cancer. Herein we reveal the synthesis, characterization and application of chitosan nanoparticles for intracellular transport of the weakly cell-penetrating amoxicillin and clavulanic acid in order to improve their efficacy on bacterial infections.

Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

2022 ◽  
Author(s):  
Nafeesa Khatoon ◽  
Zefei Zhang ◽  
Chunhui Zhou ◽  
Maoquan Chu
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Systemic Toxicity ◽  
Coated Nanoparticles ◽  
Biomimetic Approach ◽  
Targeted Drug ◽  
Macrophage Membrane

The enhanced and targeted drug delivery with low systemic toxicity and subsequent release of drugs is the major concern among researchers and pharmaceutics. Inspite of greater advancement and discoveries in...

scholarly journals A REVIEW ON CIPROFLOXACIN: DOSAGE FORM PERSPECTIVE

2018 ◽  
Vol 10 (4) ◽  
pp. 6 ◽  
Author(s):  
M. Vidyavathi ◽  
G. Srividya
Keyword(s):  
Drug Delivery ◽  
Mechanism Of Action ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Research Work ◽  
Delivery Systems ◽  
Drug Reactions ◽  
Methods Development ◽  
Pure Drug

Ciprofloxacin (CF) is one of the topmost selling antibiotics and it is available at a cheap cost which is used to treat many bacterial infections. Many research scientists are working on this drug for various applications on different drug delivery systems. The main objective of this paper is to enlighten about the details of pure drug CF and its delivery systems along with current research on this drug. This review focused on history, pharmacokinetics, mechanism of action, types of dosage form available in the market with their cost, current research going on this drug with their applications and methods development for estimation of CF. It also highlighted the possible interactions and adverse drug reactions of CF and patents available. The present review revealed that the only analytical method for estimation of CF was developed in the first decade, few drug delivery systems (DDS) of CF were developed in the second decade and more research work on the development of novel DDS of CF founded in the last decade.

scholarly journals Monitoring of Antimicrobial Drug Chloramphenicol Release from Electrospun Nano- and Microfiber Mats using UV Imaging and Bacterial Bioreporters

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 487 ◽  
Author(s):  
Preem ◽  
Bock ◽  
Hinnu ◽  
Putrinš ◽  
Sagor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Bacterial Infections ◽  
High Performance ◽  
Model Systems ◽  
Local Drug Delivery ◽  
Imaging Method ◽  
Release Behavior ◽  
Buffer Solution ◽  
Uv Imaging

New strategies are continuously sought for the treatment of skin and wound infections due to increased problems with non-healing wounds. Electrospun nanofiber mats with antibacterial agents as drug delivery systems provide opportunities for the eradication of bacterial infections as well as wound healing. Antibacterial activities of such mats are directly linked with their drug release behavior. Traditional pharmacopoeial drug release testing settings are not always suitable for analyzing the release behavior of fiber mats intended for the local drug delivery. We tested and compared different drug release model systems for the previously characterized electrospun chloramphenicol (CAM)-loaded nanofiber (polycaprolactone (PCL)) and microfiber (PCL in combination with polyethylene oxide) mats with different drug release profiles. Drug release into buffer solution and hydrogel was investigated and drug concentration was determined using either high-performance liquid chromatography, ultraviolet-visible spectrophotometry, or ultraviolet (UV) imaging. The CAM release and its antibacterial effects in disc diffusion assay were assessed by bacterial bioreporters. All tested model systems enabled to study the drug release from electrospun mats. It was found that the release into buffer solution showed larger differences in the drug release rate between differently designed mats compared to the hydrogel release tests. The UV imaging method provided an insight into the interactions with an agarose hydrogel mimicking wound tissue, thus giving us information about early drug release from the mat. Bacterial bioreporters showed clear correlations between the drug release into gel and antibacterial activity of the electrospun CAM-loaded mats.

scholarly journals Targeting gold nanocages to cancer cells for photothermal destruction and drug delivery

2010 ◽  
Vol 7 (5) ◽  
pp. 577-587 ◽  
Author(s):  
Claire M Cobley ◽  
Leslie Au ◽  
Jingyi Chen ◽  
Younan Xia
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Gold Nanocages

scholarly journals QbD-Based Development and Evaluation of Time-dependent Chronopharmaceutical Drug Delivery System of Amoxicillin Trihydrate for Management of Bacterial Infection

2018 ◽  
Vol 10 (03) ◽  
Author(s):  
Shyam Narayan Prasad ◽  
Ashok Kumar Sahoo ◽  
Abhijit V. Gothoskar
Keyword(s):  
Drug Delivery ◽  
Bacterial Infection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bacterial Infections ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Critical Material ◽  
Amoxicillin Trihydrate

The present studies discuss about the quality by design (QbD)-based development and evaluation of chronomodulated release drug delivery system of amoxicillin trihydrate for management of bacterial infection. Initially, target product profile was defined and critical quality attributes were earmarked. Risk assessment study was performed for identifying the critical material attributes. Preformulation studies were carried out, and direct compression method was employed for the preparation of bilayer matrix tablets containing a delayed and a sustained release layer for preliminary optimization. Systematic formulation optimization was carried out using central composite design by selecting the concentration of Eudragit-L100 D55 and HPMCK4M. Mathematical modeling was performed and optimized compositions of the polymers were identified from the design space. Moreover, the prepared bilayer tablets were evaluated for various tablet properties including in vitro drug release study, release kinetics evaluation and characterized for FTIR, DSC, XRD, SEM studies, in vitro was-off test, antimicrobial assay and accelerated stability studies. In a nutshell, the present studies indicated the supremacy of designing a chronomodulated release bilayer tablet formulations of amoxicillin trihydrate for effective management of bacterial infections.

scholarly journals Development and Characterization of Eucalyptus Oil Loaded Poly Lactic Co-Glycolic Acid - Albumin Nanocapsules

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
C.Sadak Vali ◽  
Abdullah Khan ◽  
M. Prathibha Bharathi ◽  
S. Siva Prasad ◽  
A. Srikanth
Keyword(s):  
Drug Delivery ◽  
Essential Oils ◽  
Bacterial Infections ◽  
Fungal Infections ◽  
Protein Complexes ◽  
Uv Spectroscopy ◽  
Drug Carrier ◽  
Nano Materials ◽  
Medical Problems ◽  
Eucalyptus Oil

Nano materials such as nanoparticles, nano capsules, nano emulsions, nano suspensions, nano spheres, solid lipid nanoparticles, dendrimers, nano tubes, nano shells, nano wires, nano pores, and quantum dots have been used extensively for delivery of therapeutic agents. Protein nanocapsules have gained significance as vehicles for targeted drug delivery due to improved ease of administration, medical imaging, gene delivery, and increased half-life of drug. Nano materials and devices are used for addressing medical problems and have established enormous potential for, subcutaneous imaging without surgical incisions. They are used in imaging of liver, lymph nodes, bone marrow, monitoring of many serious illnesses, including cancer, CVS disorders, neurological disorders, HIV/AIDS, and diabetes. They are employed as solubilizing agent for water-insoluble drugs by emulsification and designing of essential oil protein complexes which paved the path for using nano materials in drug delivery with prolonged blood circulation times. PLGA and albumin nanoparticles are considered to be a potential drug carrier with good biodegradability, biocompatibility, and non toxic nature. Eucalyptus oil contains 1,8-Cineol and ?-pinene as chief ingredients. Eucalyptus oil is known for healing of inflammation, pruritus, abscesses, sepsis, bacterial infections, blisters, boils, chicken pox, congestion, fungal infections, herpes (cold sores) and ulcers. However, these essential oils are unstable, volatile, which limits their use for new formulations. Therefore, this study focuses on developing a PLGA- Albumin nano carrier for the encapsulation of essential oils. The effects of process parameters such as the effect of heat and the concentrations of polymers were investigated. Various physicochemical characterizations such as SEM, FTIR, EE, and UV spectroscopy, Invitro drug release studies were performed.2 Formulation F4 containing 0.6 mg/ mL of PLGA and AL loaded eucalyptus loaded nanocapsules p

scholarly journals Characterization and Rate of Killing of Conjugated Silver Nanoparticles Against Selected Clinical Bacterial Isolates

2022 ◽  
Author(s):  
Stephen Oloninefa ◽  
Abalaka Moses Enemaduku ◽  
Daniyan Safiya Yahaya ◽  
Mann Abdullahi
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Bacterial Infections ◽  
Antimicrobial Agents ◽  
Silver Ions ◽  
Multidrug Resistant ◽  
Bacterial Isolates ◽  
Target Sites ◽  
Alternative Agent ◽  
The Fourier Transform

The menace of drug resistance, bioavailability and drug delivery to the target sites has motivated researchers to search for new antimicrobial agents from medicinal plants and subsequently use them for the biosynthesis of silver nanoparticles for effective killing of bacteria challenging to kill using crude extracts. The biosynthesis of silver nanoparticles was done using aqueous extract (AQE) of E<i>uphorbia heterophylla</i>, while characterization and the killing rate of conjugated silver nanoparticles (CA<sub>g</sub>NP<sub>s</sub>) were carried out using standard methods. The maximum wavelength obtained for CA<sub>g</sub>NP<sub>s</sub> was 410.33 nm, while the size distribution was 237.8 d.nm. The Fourier Transform Infra-Red result showed O-H (3308.94 cm<sup>-1</sup>), which is responsible for stabilising and reducing silver ions, while the Transmission Electron Microscopy revealed the presence of monodispersed spherical shapes CA<sub>g</sub>NP<sub>s</sub>. The Energy Dispersive Spectroscopy confirmed the presence of silver. There were reductions in the clinical bacterial isolates exposed to CA<sub>g</sub>NP<sub>s</sub> as the exposure time increased. <i>Escherichia coli</i> was killed between 6-7 h while<i> Salmonella typhimurium</i> was killed at the seven has the value of 0.00 log<sub>10</sub> CFU/ml was recorded respectively. However, there were increments in the populations of clinical bacterial isolates in control as the time of exposure increased. Therefore, the study suggests that the CA<sub>g</sub>NP<sub>s</sub> exhibit intense antimicrobial activity and the potential to be developed as an alternative agent to treat bacterial infections, curb multidrug-resistant bacterial infection, and promote speedy drug delivery to the target sites.

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