scholarly journals Single-Molecule Spectroscopy: In Situ Two-Step Photoreduced SERS Materials for On-Chip Single-Molecule Spectroscopy with High Reproducibility (Adv. Mater. 36/2017)

2017 ◽  
Vol 29 (36) ◽  
Author(s):  
Wenjie Yan ◽  
Longkun Yang ◽  
Jianing Chen ◽  
Yaqi Wu ◽  
Peijie Wang ◽  
...  
Keyword(s):  
Single Molecule ◽  
Single Molecule Spectroscopy ◽  
High Reproducibility ◽  
On Chip

In Situ Two-Step Photoreduced SERS Materials for On-Chip Single-Molecule Spectroscopy with High Reproducibility

2017 ◽  
Vol 29 (36) ◽  
pp. 1702893 ◽  
Author(s):  
Wenjie Yan ◽  
Longkun Yang ◽  
Jianing Chen ◽  
Yaqi Wu ◽  
Peijie Wang ◽  
...  
Keyword(s):  
Single Molecule ◽  
Single Molecule Spectroscopy ◽  
High Reproducibility ◽  
On Chip

In situ study of RSK2 kinase activity in a single living cell by combining single molecule spectroscopy with activity-based probes

The Analyst ◽  
2019 ◽  
Vol 144 (12) ◽  
pp. 3756-3764
Author(s):  
Shengrong Yu ◽  
Zhixue Du ◽  
Chaoqing Dong ◽  
Jicun Ren
Keyword(s):  
Protein Kinases ◽  
Single Molecule ◽  
Living Cell ◽  
Kinase Activity ◽  
Living Cells ◽  
Single Molecule Spectroscopy ◽  
In Situ Study ◽  
Endogenous Protein ◽  
Single Living

FCS with the ABP strategy is a very promising method for studying endogenous protein kinases in living cells.

scholarly journals Laser-excited elastic guided waves reveal the complex mechanics of nanoporous silicon

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Marc Thelen ◽  
Nicolas Bochud ◽  
Manuel Brinker ◽  
Claire Prada ◽  
Patrick Huber
Keyword(s):  
Guided Waves ◽  
Laser Ultrasonics ◽  
Bulk Silicon ◽  
Nanoporous Silicon ◽  
Stiffness Reduction ◽  
Mechanical Characterisation ◽  
Isotropic Elasticity ◽  
On Chip ◽  
Non Destructive

AbstractNanoporosity in silicon leads to completely new functionalities of this mainstream semiconductor. A difficult to assess mechanics has however significantly limited its application in fields ranging from nanofluidics and biosensorics to drug delivery, energy storage and photonics. Here, we present a study on laser-excited elastic guided waves detected contactless and non-destructively in dry and liquid-infused single-crystalline porous silicon. These experiments reveal that the self-organised formation of 100 billions of parallel nanopores per square centimetre cross section results in a nearly isotropic elasticity perpendicular to the pore axes and an 80% effective stiffness reduction, altogether leading to significant deviations from the cubic anisotropy observed in bulk silicon. Our thorough assessment of the wafer-scale mechanics of nanoporous silicon provides the base for predictive applications in robust on-chip devices and evidences that recent breakthroughs in laser ultrasonics open up entirely new frontiers for in-situ, non-destructive mechanical characterisation of dry and liquid-functionalised porous materials.

scholarly journals Controlled density glycodendron microarrays for studying carbohydrate–lectin interactions

2021 ◽  
Author(s):  
Antonio Di Maio ◽  
Anna Cioce ◽  
Silvia Achilli ◽  
Michel Thépaut ◽  
Corinne Vivès ◽  
...  
Keyword(s):  
Maldi Tof Ms ◽  
Maldi Tof ◽  
On Chip ◽  
Tof Ms

Density depended binding and selectivity is studied on glycodendron microarray with defined valency, which were prepared by on-chip synthesis and analysed by in situ MALDI-TOF MS.

scholarly journals Tuning Single-Molecule Conductance by Controlled Electric Field-Induced trans-to-cis Isomerisation

2021 ◽  
Vol 11 (8) ◽  
pp. 3317
Author(s):  
C.S. Quintans ◽  
Denis Andrienko ◽  
Katrin F. Domke ◽  
Daniel Aravena ◽  
Sangho Koo ◽  
...  
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Single Molecule ◽  
Quantum Interference ◽  
Single Molecule Level ◽  
Wet Chemical Synthesis ◽  
Single Molecule Junctions ◽  
Tunnelling Microscopy ◽  
The Difference

External electric fields (EEFs) have proven to be very efficient in catalysing chemical reactions, even those inaccessible via wet-chemical synthesis. At the single-molecule level, oriented EEFs have been successfully used to promote in situ single-molecule reactions in the absence of chemical catalysts. Here, we elucidate the effect of an EEFs on the structure and conductance of a molecular junction. Employing scanning tunnelling microscopy break junction (STM-BJ) experiments, we form and electrically characterize single-molecule junctions of two tetramethyl carotene isomers. Two discrete conductance signatures show up more prominently at low and high applied voltages which are univocally ascribed to the trans and cis isomers of the carotenoid, respectively. The difference in conductance between both cis-/trans- isomers is in concordance with previous predictions considering π-quantum interference due to the presence of a single gauche defect in the trans isomer. Electronic structure calculations suggest that the electric field polarizes the molecule and mixes the excited states. The mixed states have a (spectroscopically) allowed transition and, therefore, can both promote the cis-isomerization of the molecule and participate in electron transport. Our work opens new routes for the in situ control of isomerisation reactions in single-molecule contacts.

In-situ control of on-chip angstrom gaps, atomic switches, and molecular junctions by light irradiation

Nano Today ◽  
2021 ◽  
Vol 39 ◽  
pp. 101226
Author(s):  
Surong Zhang ◽  
Chenyang Guo ◽  
Lifa Ni ◽  
Kerstin M. Hans ◽  
Weiqiang Zhang ◽  
...  
Keyword(s):  
Molecular Junctions ◽  
Light Irradiation ◽  
In Situ Control ◽  
On Chip

In Situ Nanopore Fabrication and Single-Molecule Sensing with Microscale Liquid Contacts

ACS Nano ◽  
2017 ◽  
Vol 11 (5) ◽  
pp. 4907-4915 ◽  
Author(s):  
Christopher E. Arcadia ◽  
Carlos C. Reyes ◽  
Jacob K. Rosenstein
Keyword(s):  
Single Molecule
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