Nanomaterials in Neural-Stem-Cell-Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases

2018 ◽  
Vol 30 (17) ◽  
pp. 1705694 ◽  
Author(s):  
Bingbo Zhang ◽  
Wei Yan ◽  
Yanjing Zhu ◽  
Weitao Yang ◽  
Wenjun Le ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Neural Stem Cell ◽  
Neurological Diseases

scholarly journals Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine

2021 ◽  
Vol 9 ◽  
Author(s):  
Tomomi Sato ◽  
Takumi Ito ◽  
Hiroshi Handa
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Neural Stem Cells ◽  
Neural Stem Cell ◽  
Small Molecule ◽  
Molecular Mechanisms ◽  
Brain Size ◽  
Therapeutic Effects ◽  
Sedative Drug

Thalidomide, a sedative drug that was once excluded from the market owing to its teratogenic properties, was later found to be effective in treating multiple myeloma. We had previously demonstrated that cereblon (CRBN) is the target of thalidomide embryopathy and acts as a substrate receptor for the E3 ubiquitin ligase complex, Cullin-Ring ligase 4 (CRL4CRBN) in zebrafish and chicks. CRBN was originally identified as a gene responsible for mild intellectual disability in humans. Fetuses exposed to thalidomide in early pregnancy were at risk of neurodevelopmental disorders such as autism, suggesting that CRBN is involved in prenatal brain development. Recently, we found that CRBN controls the proliferation of neural stem cells in the developing zebrafish brain, leading to changes in brain size. Our findings imply that CRBN is involved in neural stem cell growth in humans. Accumulating evidence shows that CRBN is essential not only for the teratogenic effects but also for the therapeutic effects of thalidomide. This review summarizes recent progress in thalidomide and CRBN research, focusing on the teratogenic and therapeutic effects. Investigation of the molecular mechanisms underlying the therapeutic effects of thalidomide and its derivatives, CRBN E3 ligase modulators (CELMoDs), reveals that these modulators provide CRBN the ability to recognize neosubstrates depending on their structure. Understanding the therapeutic effects leads to the development of a novel technology called CRBN-based proteolysis-targeting chimeras (PROTACs) for target protein knockdown. These studies raise the possibility that CRBN-based small-molecule compounds regulating the proliferation of neural stem cells may be developed for application in regenerative medicine.

scholarly journals The Situation and Issues for Neural Stem Cell on Regenerative Medicine

2009 ◽  
Vol 14 (8) ◽  
pp. 24-29
Author(s):  
Yoshimi YASHIRO ◽  
Hideyuki OKANO
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Neural Stem Cell

Author response for "Inhibition of neural stem cell aging through the transient induction of reprogramming factors"

2020 ◽  
Author(s):  
Min Ji Han ◽  
Won Ji Lee ◽  
Joonhyuk Choi ◽  
Yean Ju Hong ◽  
Sang Jun Uhm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Author Response ◽  
Cell Aging ◽  
Stem Cell Aging ◽  
Reprogramming Factors

Neural Stem Cell Culture: Neurosphere generation, microscopical analysis and cryopreservation

2006 ◽  
Author(s):  
Laura Pacey ◽  
Shelley Stead ◽  
Jacqueline Gleave ◽  
Kasia Tomczyk ◽  
Laurie Doering
Keyword(s):  
Cell Culture ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Culture ◽  
Microscopical Analysis
Sign in / Sign up

Export Citation Format

Share Document