A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy

2015 ◽  
Vol 27 (34) ◽  
pp. 5034-5042 ◽  
Author(s):  
Ya Liu ◽  
Di Zhang ◽  
Zeng-Ying Qiao ◽  
Guo-Bin Qi ◽  
Xing-Jie Liang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tissue Penetration ◽  
Deep Tissue

scholarly journals Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy

2020 ◽  
pp. 2002525
Author(s):  
Mi Mi Wan ◽  
Huan Chen ◽  
Zhong Da Wang ◽  
Zhi Yong Liu ◽  
Yue Qi Yu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Multidrug Resistance ◽  
Cancer Therapy ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Resistance Reversal

scholarly journals A self-illuminating nanoparticle for inflammation imaging and cancer therapy

2019 ◽  
Vol 5 (1) ◽  
pp. eaat2953 ◽  
Author(s):  
Xiaoqiu Xu ◽  
Huijie An ◽  
Dinglin Zhang ◽  
Hui Tao ◽  
Yin Dou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
In Vivo Imaging ◽  
Resonance Energy ◽  
External Irradiation ◽  
Tissue Penetration ◽  
Photodynamic Therapy Of Cancer ◽  
Inflammation Imaging

Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibility of the nanoparticles. To overcome these critical limitations, we synthesized a sensitive, specific, biodegradable luminescent nanoparticle that is self-assembled from an amphiphilic polymeric conjugate with a luminescent donor (luminol) and a fluorescent acceptor [chlorin e6 (Ce6)] for in vivo luminescence imaging and photodynamic therapy in deep tissues. Mechanistically, reactive oxygen species (ROS) and myeloperoxidase generated in inflammatory sites or the tumor microenvironment trigger bioluminescence resonance energy transfer and the production of singlet oxygen (1O2) from the nanoparticle, enabling in vivo imaging and cancer therapy, respectively. This self-illuminating nanoparticle shows an excellent in vivo imaging capability with suitable tissue penetration and resolution in diverse animal models of inflammation. It is also proven to be a selective, potent, and safe antitumor nanomedicine that specifically kills cancer cells via in situ1O2produced in the tumor microenvironment, which contains a high level of ROS.

A triple modality BSA-coated dendritic nanoplatform for NIR imaging, enhanced tumor penetration and anticancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (19) ◽  
pp. 9021-9037 ◽  
Author(s):  
Jie Cao ◽  
Ruifen Ge ◽  
Min Zhang ◽  
Junfei Xia ◽  
Shangcong Han ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Anticancer Therapy ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Tumor Penetration ◽  
Nir Imaging

A simple PAMAM-based theranostic system was successfully designed for NIR imaging, deep tissue penetration and cancer therapy.

scholarly journals Targeting the Ubiquitin Signaling Cascade in Tumor Microenvironment for Cancer Therapy

2021 ◽  
Vol 22 (2) ◽  
pp. 791
Author(s):  
Qi Liu ◽  
Bayonle Aminu ◽  
Olivia Roscow ◽  
Wei Zhang
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Therapeutic Agents ◽  
Biological Processes ◽  
Post Translational Modification ◽  
E3 Ligases ◽  
Tumor Microenvironments ◽  
Cellular Immune ◽  
Ubiquitin Conjugating Enzymes ◽  
Cellular Components

Tumor microenvironments are composed of a myriad of elements, both cellular (immune cells, cancer-associated fibroblasts, mesenchymal stem cells, etc.) and non-cellular (extracellular matrix, cytokines, growth factors, etc.), which collectively provide a permissive environment enabling tumor progression. In this review, we focused on the regulation of tumor microenvironment through ubiquitination. Ubiquitination is a reversible protein post-translational modification that regulates various key biological processes, whereby ubiquitin is attached to substrates through a catalytic cascade coordinated by multiple enzymes, including E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes and E3 ubiquitin ligases. In contrast, ubiquitin can be removed by deubiquitinases in the process of deubiquitination. Here, we discuss the roles of E3 ligases and deubiquitinases as modulators of both cellular and non-cellular components in tumor microenvironment, providing potential therapeutic targets for cancer therapy. Finally, we introduced several emerging technologies that can be utilized to develop effective therapeutic agents for targeting tumor microenvironment.

Targeting HDL in tumor microenvironment: New hope for cancer therapy

2021 ◽  
Author(s):  
Tan‐Jun Zhao ◽  
Neng Zhu ◽  
Ya‐Ning Shi ◽  
Yu‐Xiang Wang ◽  
Chan‐Juan Zhang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy
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