A Novel Bioassay Platform Using Ferritin-Based Nanoprobe Hydrogel

2012 ◽  
Vol 24 (35) ◽  
pp. 4739-4744 ◽  
Author(s):  
Eun Jung Lee ◽  
Keum-Young Ahn ◽  
Jong-Hwan Lee ◽  
Jin-Seung Park ◽  
Jong-Am Song ◽  
...  
Keyword(s):  
Bioassay Platform

A novel magnetic bead bioassay platform using a microchip-based sensor for infectious disease diagnosis

2006 ◽  
Vol 314 (1-2) ◽  
pp. 21-29 ◽  
Author(s):  
Turgut Aytur ◽  
Jonathan Foley ◽  
Mekhail Anwar ◽  
Bernhard Boser ◽  
Eva Harris ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Magnetic Bead ◽  
Disease Diagnosis ◽  
Bioassay Platform

scholarly journals Biomedical Applications: A Novel Bioassay Platform Using Ferritin-Based Nanoprobe Hydrogel (Adv. Mater. 35/2012)

2012 ◽  
Vol 24 (35) ◽  
pp. 4730-4730
Author(s):  
Eun Jung Lee ◽  
Keum-Young Ahn ◽  
Jong-Hwan Lee ◽  
Jin-Seung Park ◽  
Jong-Am Song ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Bioassay Platform

Coding and decoding stray magnetic fields for multiplexing kinetic bioassay platform

Lab on a Chip ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 4561-4571
Author(s):  
Yuan Liu ◽  
Gungun Lin ◽  
Yinghui Chen ◽  
Ingolf Mönch ◽  
Denys Makarov ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Magnetic Beads ◽  
Bioassay Platform

The stray magnetic fields of hierarchically-assembled magnetic beads are utilised to code and decode information for multiplexed kinetic assays.

scholarly journals Fluorescence-enhanced bio-detection platforms obtained through controlled “step-by-step” clustering of silver nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 848-855 ◽  
Author(s):  
Panpan Liu ◽  
Ying Zhou ◽  
Min Guo ◽  
Shuguang Yang ◽  
Olivier Félix ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Bioassay Platform

A fluorescence-based bioassay platform prepared by using the versatile, scalable and cheap spray-assisted step-by-step assembly of silver nanoparticles.

scholarly journals Multi-dimensional digital bioassay platform based on an air-sealed femtoliter reactor array device

2020 ◽  
Author(s):  
Shingo Honda ◽  
Yoshihiro Minagawa ◽  
Hiroyuki Noji ◽  
Kazuhito V. Tabata
Keyword(s):  
Single Molecule ◽  
Influenza A ◽  
Neuraminidase Inhibitor ◽  
Exchange System ◽  
Virus Particles ◽  
Solution Exchange ◽  
Biological Phenomena ◽  
Bioassay Platform ◽  
Enzyme Molecules ◽  
Biological Entities

AbstractSingle-molecule experiments have been helping us to get deeper inside biological phenomena by illuminating how individual molecules actually work. Digital bioassay, in which analyte molecules are individually confined in small compartments to be analyzed, is an emerging technology in single-molecule biology and applies to various biological entities (e.g., cells and virus particles). However, digital bioassay is not compatible with multi-conditional or multi-parametric assays, hindering understanding of analytes. This is because current digital bioassay lacks a repeatable solution-exchange system that keeps analytes inside compartments. To address this challenge, we developed a new digital bioassay platform with easy solution exchanges, called multi-dimensional (MD) digital bioassay, and tested its quantitativity and utility. We immobilized single analytes in arrayed femtoliter (10−15 L) reactors and sealed them with airflow. The solution in each reactor was stable and showed no cross-talk via solution leakage for more than 2 h, and over 30 rounds of perfect solution exchanges were successfully performed. To show the utility of our system, we investigated neuraminidase inhibitor (NAI) sensitivity on single influenza A virus (IAV) particles in a multi-conditional assay. We proved that IAV particles show a heterogeneous response to the NAI. Further, to demonstrate multi-parametric assays, we examined the sensitivity of individual IAV particles or model enzyme molecules to two different inhibitors. Our results support that MD digital bioassay is a versatile platform to unveil heterogeneities of biological entities in unprecedented resolution.

scholarly journals An Oil-Free Picodrop Bioassay Platform for Synthetic Biology

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Christian A. Siltanen ◽  
Russell H. Cole ◽  
Sean Poust ◽  
Lawrence Chao ◽  
Jabus Tyerman ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Bioassay Platform

scholarly journals Multidimensional Digital Bioassay Platform Based on an Air-Sealed Femtoliter Reactor Array Device

2021 ◽  
Author(s):  
Shingo Honda ◽  
Yoshihiro Minagawa ◽  
Hiroyuki Noji ◽  
Kazuhito V. Tabata
Keyword(s):  
Bioassay Platform

Bioassay platform for fiber coupled avalanche photodiode for improved biomolecule detection

2006 ◽  
Author(s):  
M. Mac Sweeney ◽  
F. Lin ◽  
C. Jackson ◽  
M. Manning ◽  
M. M. Sheehan ◽  
...  
Keyword(s):  
Avalanche Photodiode ◽  
Biomolecule Detection ◽  
Bioassay Platform

ChemInform Abstract: SERS as a Bioassay Platform: Fundamentals, Design, and Applications

ChemInform ◽  
2008 ◽  
Vol 39 (32) ◽  
Author(s):  
Marc D. Porter ◽  
Robert J. Lipert ◽  
Lorraine M. Siperko ◽  
Gufeng Wang ◽  
Radha Narayanan
Keyword(s):  
Bioassay Platform
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