In Situ Forming, Silanized Hyaluronic Acid Hydrogels with Fine Control Over Mechanical Properties and In Vivo Degradation for Tissue Engineering Applications

2020 ◽  
Vol 9 (19) ◽  
pp. 2000981
Author(s):  
Killian Flegeau ◽  
Claire Toquet ◽  
Gildas Rethore ◽  
Cyril d'Arros ◽  
Léa Messager ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Engineering Applications ◽  
In Situ Forming ◽  
Fine Control ◽  
In Vivo Degradation

scholarly journals Fabrication, Crystalline Behavior, Mechanical Property and In-Vivo Degradation of Poly(l–lactide) (PLLA)–Magnesium Oxide Whiskers (MgO) Nano Composites Prepared by In-Situ Polymerization

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1123 ◽  
Author(s):  
Hui Liang ◽  
Yun Zhao ◽  
Jinjun Yang ◽  
Xiao Li ◽  
Xiaoxian Yang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnesium Oxide ◽  
Bone Repair ◽  
In Situ Polymerization ◽  
Resonance Spectroscopy ◽  
Scanning Calorimetry ◽  
Biomedical Material ◽  
In Vivo Degradation

The present work focuses on the preparation of poly(l–lactide)–magnesium oxide whiskers (PLLA–MgO) composites by the in-situ polymerization method for bone repair and implant. PLLA–MgO composites were evaluated using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and solid-state 13C and 1H nuclear magnetic resonance spectroscopy (NMR). It was found that the whiskers were uniformly dispersed in the PLLA matrix through the interfacial interaction bonding between PLLA and MgO; thereby, the MgO whisker was found to be well-distributed in the PLLA matrix, and biocomposites with excellent interface bonding were produced. Notably, the MgO whisker has an effect on the crystallization behavior and mechanical properties; moreover, the in vivo degradation of PLLA–MgO composites could also be adjusted by MgO. These results show that the whisker content of 0.5 wt % and 1.0 wt % exhibited a prominent nucleation effect for the PLLA matrix, and specifically 1.0 wt % MgO was found to benefit the enhanced mechanical properties greatly. In addition, the improvement of the degrading process of the composite illustrated that the MgO whisker can effectively regulate the degradation of the PLLA matrix as well as raise its bioactivity. Hence, these results demonstrated the promising application of PLLA–MgO composite to serve as a biomedical material for bone-related repair.

In situ-forming, mechanically resilient hydrogels for cell delivery

2019 ◽  
Vol 7 (38) ◽  
pp. 5742-5761 ◽  
Author(s):  
Stuart A. Young ◽  
Hossein Riahinezhad ◽  
Brian G. Amsden
Keyword(s):  
Tissue Engineering ◽  
Minimally Invasive ◽  
Cell Delivery ◽  
Engineering Applications ◽  
Cell Retention ◽  
In Situ Forming ◽  
Defect Sites

Injectable, in situ-forming hydrogels can improve cell delivery in tissue engineering applications by facilitating minimally invasive delivery to irregular defect sites and improving cell retention and survival.

scholarly journals Responsive and in situ-forming chitosan scaffolds for bone tissue engineering applications: an overview of the last decade

2010 ◽  
Vol 20 (9) ◽  
pp. 1638-1645 ◽  
Author(s):  
Ana M. Martins ◽  
Catarina M. Alves ◽  
F. Kurtis Kasper ◽  
Antonios G. Mikos ◽  
Rui L. Reis
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
In Situ Forming ◽  
Chitosan Scaffolds

IN VITRO AND IN VIVO DEGRADATION OF A TWISTED SILK FIBROIN–POLY(LACTIC-CO-GLYCOLIC ACID) FIBER COMPOSITE ROPE-LIKE SCAFFOLD AND CHANGES IN ITS MECHANICAL PROPERTIES

2016 ◽  
Vol 16 (04) ◽  
pp. 1650053
Author(s):  
WENYUAN ZHANG ◽  
YADONG YANG ◽  
KEJI ZHANG ◽  
YING LI ◽  
GUOJIAN FANG
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Tissue Engineering ◽  
Mass Loss ◽  
Silk Fibroin ◽  
Glycolic Acid ◽  
Property Loss ◽  
In Vivo Degradation

Natural silk fibroin fiber is slowly degraded, which makes it difficult to be replaced quickly by regenerating tissues of tissue engineering. We used poly(lactic-co-glycolic acid) (PLGA, lactic acid:glycolic acid [Formula: see text] 10:90) fibers to adjust the overall degradation rate of the scaffolds. This study fabricated a three-strand helical composite rope-like scaffold from silk fibroin and PLGA fibers (silk fibroin:PLGA [Formula: see text] 36:64) using a twisting method. In vitro and in vivo degradation experiments were performed over 16 weeks. Results suggest that the in vitro and in vivo degradation tendencies of the scaffold were similar, with mass loss lagging behind mechanical property loss. The speed of degradation in vivo was faster than that in vitro. Mechanical property loss of the scaffold was fast during the first three weeks, when mass loss was slow. Mass loss rate accelerated from weeks 3 to 8. The mass and mechanical properties were relatively stable from 8 to 16 weeks. After 16 weeks of degradation, the scaffold still had considerably strong mechanical properties. The scaffold showed a reasonable and suitable degradation speed with good histocompatibility for ligament tissue engineering.

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