scholarly journals Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting

2019 ◽  
Vol 8 (18) ◽  
pp. 1900352 ◽  
Author(s):  
Bernard Manuel Haryadi ◽  
Daniel Hafner ◽  
Ihsan Amin ◽  
Rene Schubel ◽  
Rainer Jordan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Shape Stability ◽  
Nanoparticle Shape

scholarly journals Recent Advances in Nanoparticle Shape and Composition Regulation Based on Galvanic Replacement for Cancer Treatment

2018 ◽  
Author(s):  
Woojun Shin ◽  
Kyungtae Kang ◽  
Hongje Jang
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Cancer Treatment ◽  
Synthetic Methods ◽  
Galvanic Replacement ◽  
Future Outlook ◽  
Composition Control ◽  
Nanoparticle Shape ◽  
Recent Advances ◽  
Constituent Elements

Owing to their unique physicochemical properties, nanoparticles are used in a variety of ways in the field of cancer treatment, including imaging, drug delivery, and photothermal and photodynamic therapies. The fascinating properties of nanoparticles are determined by their size, morphology, and constituent elements, and various synthetic methods and post-synthetic techniques have been applied to control these factors. Herein, we present examples of shape and composition control through galvanic replacement, a technique that exploits redox potential differences between elements to induce spontaneous ion-exchange and highlight its specific contributions to cancer treatment applications. The present article identifies the recent advances in nanoparticle formation techniques and discusses the future outlook of the field.

Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines

2018 ◽  
Vol 8 (1) ◽  
pp. 394-406 ◽  
Author(s):  
T. R. Nizamov ◽  
A. S. Garanina ◽  
I. S. Grebennikov ◽  
O. A. Zhironkina ◽  
O. S. Strelkova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cell Lines ◽  
Iron Oxide Nanoparticle ◽  
Nanoparticle Shape ◽  
Oxide Nanoparticle

Combining Nanoparticle Shape Modulation and Polymersome Technology in Drug Delivery

2021 ◽  
Vol 4 (4) ◽  
pp. 2853-2862
Author(s):  
Cara Katterman ◽  
Christopher Pierce ◽  
Jessica Larsen
Keyword(s):  
Drug Delivery ◽  
Nanoparticle Shape ◽  
Shape Modulation

The importance of nanoparticle shape in cancer drug delivery

2014 ◽  
Vol 12 (1) ◽  
pp. 129-142 ◽  
Author(s):  
Nghia P Truong ◽  
Michael R Whittaker ◽  
Catherine W Mak ◽  
Thomas P Davis
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Nanoparticle Shape ◽  
Cancer Drug Delivery

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Nanotheranostic agents for neurodegenerative diseases

2020 ◽  
Vol 4 (6) ◽  
pp. 645-675
Author(s):  
Parasuraman Padmanabhan ◽  
Mathangi Palanivel ◽  
Ajay Kumar ◽  
Domokos Máthé ◽  
George K. Radda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Cell Types ◽  
Specific Cell ◽  
Ageing Population ◽  
Target Tissue ◽  
Therapeutic Approaches ◽  
Surface Receptors ◽  
Theranostic Agents ◽  
Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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