scholarly journals Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery

2019 ◽  
Vol 8 (9) ◽  
pp. 1801510 ◽  
Author(s):  
Maelíosa T. C. Mc Crudden ◽  
Eneko Larrañeta ◽  
Annie Clark ◽  
Courtney Jarrahian ◽  
Annie Rein‐Weston ◽  
...  
Keyword(s):  
Intravaginal Delivery

A Novel Intravaginal Delivery System for Itraconazole: In Vitro and In Vivo Evaluation

2009 ◽  
Vol 6 (2) ◽  
pp. 151-158 ◽  
Author(s):  
N. Dobaria ◽  
R. Mashru ◽  
A. Badhan ◽  
A. Thakkar
Keyword(s):  
Delivery System ◽  
In Vivo Evaluation ◽  
Intravaginal Delivery

scholarly journals Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir

Biomaterials ◽  
2017 ◽  
Vol 144 ◽  
pp. 144-154 ◽  
Author(s):  
Muneeb Mohideen ◽  
Elias Quijano ◽  
Eric Song ◽  
Yang Deng ◽  
Gauri Panse ◽  
...  
Keyword(s):  
Intravaginal Delivery

Safety and immunogenicity of intramuscular and intravaginal delivery of HIV-1 DNA constructs to infant chimpanzees

1997 ◽  
Vol 26 (1-2) ◽  
pp. 27-33 ◽  
Author(s):  
Mark L. Bagarazzi ◽  
Jean D. Boyer ◽  
M. AM Javadian ◽  
Michael Chattergoon ◽  
Kesen Dang ◽  
...  
Keyword(s):  
Intravaginal Delivery ◽  
Hiv 1 ◽  
Infant Chimpanzees

scholarly journals Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Franklin Chimaobi Kenechukwu ◽  
Anthony Amaechi Attama ◽  
Emmanuel Chinedum Ibezim ◽  
Petra Obioma Nnamani ◽  
Chukwuebuka Emmanuel Umeyor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Fungicidal Activity ◽  
Inhibition Zone ◽  
Vaginal Drug Delivery ◽  
Miconazole Nitrate ◽  
Peg 4000 ◽  
Topical Solution ◽  
Anticandidal Activity ◽  
Intravaginal Delivery

The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvovaginal candidiasis (VVC). Lipid matrices (LMs) consisting of rational blends of SF and SO with or without PEG-4000 were prepared by fusion and characterized and employed to formulate MN-loaded solid lipid microparticles (SLMs) by melt-homogenization. The SLMs were characterized for physicochemical properties, anticandidal activity, and stability. Spherical discrete microparticles with good physicochemical properties and mean diameters suitable for vaginal drug delivery were obtained. Formulations based on SO:SF (1:9) and containing highest concentrations of PEG-4000 (4 %w/w) and MN (3.0 %w/w) were stable and gave highest encapsulation efficiency (83.05–87.75%) and inhibition zone diameter (25.87±0.94–26.33±0.94 mm) and significantly (p<0.05) faster and more powerful fungicidal activity regarding killing rate constant values (7.10 x 10−3–1.09 x 10−2 min−1) than commercial topical solution of MN (Fungusol®) (8.00 x 10−3 min−1) and pure MN sample (5.160 x 10−3 min−1). This study has shown that MN-loaded SLMs based on molecularly PEGylated lipid matrices could provide a better option to deal with VVC.

scholarly journals Submicron Matrices Embedded in a Polymeric Caplet for Extended Intravaginal Delivery of Zidovudine

2017 ◽  
Vol 19 (6) ◽  
pp. 1745-1759 ◽  
Author(s):  
Felix Mashingaidze ◽  
Yahya E. Choonara ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
Vinesh Maharaj ◽  
...  
Keyword(s):  
Intravaginal Delivery
Sign in / Sign up

Export Citation Format

Share Document