PEGylation Regulates Self‐Assembled Small‐Molecule Dye–Based Probes from Single Molecule to Nanoparticle Size for Multifunctional NIR‐II Bioimaging

2018 ◽  
Vol 7 (23) ◽  
pp. 1800973 ◽  
Author(s):  
Feng Ding ◽  
Chonglu Li ◽  
Yuling Xu ◽  
Jiaxin Li ◽  
Haibing Li ◽  
...  
Keyword(s):  
Small Molecule ◽  
Single Molecule ◽  
Nanoparticle Size ◽  
Self Assembled

scholarly journals Magnetic Hysteresis at 10 K in Single Molecule Magnet Self‐Assembled on Gold

2021 ◽  
pp. 2000777
Author(s):  
Chia‐Hsiang Chen ◽  
Lukas Spree ◽  
Emmanouil Koutsouflakis ◽  
Denis S. Krylov ◽  
Fupin Liu ◽  
...  
Keyword(s):  
Single Molecule ◽  
Magnetic Hysteresis ◽  
Single Molecule Magnet ◽  
Self Assembled

The dynamic behaviour of a single molecule inserted in a self-assembled monolayer matrix at low temperature

2004 ◽  
Vol 15 (4) ◽  
pp. S137-S141 ◽  
Author(s):  
Satoshi Wakamatsu ◽  
Shintaro Fujii ◽  
Uichi Akiba ◽  
Masamichi Fujihira
Keyword(s):  
Low Temperature ◽  
Single Molecule ◽  
Dynamic Behaviour ◽  
Self Assembled Monolayer ◽  
Self Assembled

scholarly journals Designed Anchoring Geometries Determine Lifetimes of Biotin-Streptavidin Bonds under Constant Load and Enable Ultra-Stable Coupling

2020 ◽  
Author(s):  
Sophia Gruber ◽  
Achim Löf ◽  
Steffen M. Sedlak ◽  
Martin Benoit ◽  
Hermann E. Gaub ◽  
...  
Keyword(s):  
Small Molecule ◽  
Single Molecule ◽  
Force Spectroscopy ◽  
Constant Load ◽  
Pivotal Role ◽  
Medical Applications ◽  
Biotechnological Applications ◽  
Single Molecule Force Spectroscopy ◽  
Directional Dependence ◽  
Magnetic Tweezer

AbstractThe small molecule biotin and the homotetrameric protein streptavidin (SA) form a stable and robust complex that plays a pivotal role in many biotechnological and medical applications. In particular, the biotin-streptavidin linkage is frequently used in single molecule force spectroscopy (SMFS) experiments. Recent data suggest that biotin-streptavidin bonds show strong directional dependence and a broad range of multi-exponential lifetimes under load. Here, we investigate engineered SA variants with different valencies and a unique tethering point under constant forces using a magnetic tweezer assay. We observed two orders-of-magnitude differences in the lifetimes, which we attribute to the distinct force loading geometries in the different SA variants. We identified an especially long-lived tethering geometry that will facilitate ultra-stable SMFS experiments and pave the way for new biotechnological applications.

scholarly journals KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics

2018 ◽  
Vol 115 (20) ◽  
pp. E4613-E4622 ◽  
Author(s):  
Bojan Milic ◽  
Anirban Chakraborty ◽  
Kyuho Han ◽  
Michael C. Bassik ◽  
Steven M. Block
Keyword(s):  
Cancer Cell ◽  
Small Molecule ◽  
Single Molecule ◽  
Small Molecule Inhibitors ◽  
Cancer Cell Growth ◽  
Combination Drug ◽  
Cancer Chemotherapeutics ◽  
Development Of Resistance ◽  
Molecule Inhibitor ◽  
Mechanochemical Cycle

Eg5, a mitotic kinesin, has been a target for anticancer drug development. Clinical trials of small-molecule inhibitors of Eg5 have been stymied by the development of resistance, attributable to mitotic rescue by a different endogenous kinesin, KIF15. Compared with Eg5, relatively little is known about the properties of the KIF15 motor. Here, we employed single-molecule optical-trapping techniques to define the KIF15 mechanochemical cycle. We also studied the inhibitory effects of KIF15-IN-1, an uncharacterized, commercially available, small-molecule inhibitor, on KIF15 motility. To explore the complementary behaviors of KIF15 and Eg5, we also scored the effects of small-molecule inhibitors on admixtures of both motors, using both a microtubule (MT)-gliding assay and an assay for cancer cell viability. We found that (i) KIF15 motility differs significantly from Eg5; (ii) KIF15-IN-1 is a potent inhibitor of KIF15 motility; (iii) MT gliding powered by KIF15 and Eg5 only ceases when both motors are inhibited; and (iv) pairing KIF15-IN-1 with Eg5 inhibitors synergistically reduces cancer cell growth. Taken together, our results lend support to the notion that a combination drug therapy employing both inhibitors may be a viable strategy for overcoming chemotherapeutic resistance.

Self-Assembled Monolayer Immobilized Gold Nanoparticles for Plasmonic Effects in Small Molecule Organic Photovoltaic

2013 ◽  
Vol 5 (3) ◽  
pp. 511-517 ◽  
Author(s):  
Ming-Chung Chen ◽  
Yi-Ling Yang ◽  
Shin-Wen Chen ◽  
Jia-Han Li ◽  
Muluken Aklilu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Small Molecule ◽  
Organic Photovoltaic ◽  
Self Assembled Monolayer ◽  
Self Assembled ◽  
Plasmonic Effects

Measurements of Single-Molecule Bond-Rupture Forces between Self-Assembled Monolayers of Organosilanes with the Atomic Force Microscope

Langmuir ◽  
1997 ◽  
Vol 13 (14) ◽  
pp. 3761-3768 ◽  
Author(s):  
L. A. Wenzler ◽  
G. L. Moyes ◽  
G. N. Raikar ◽  
R. L. Hansen ◽  
J. M. Harris ◽  
...  
Keyword(s):  
Atomic Force Microscope ◽  
Single Molecule ◽  
Self Assembled Monolayers ◽  
Bond Rupture ◽  
Atomic Force ◽  
Assembled Monolayers ◽  
Self Assembled

A surprising way to control the charge transport in molecular electronics: the subtle impact of the coverage of self-assembled monolayers of floppy molecules adsorbed on metallic electrodes

2017 ◽  
Vol 204 ◽  
pp. 35-52 ◽  
Author(s):  
Ioan Bâldea
Keyword(s):  
Molecular Electronics ◽  
Single Molecule ◽  
Molecular Species ◽  
Molecular Conformation ◽  
Theoretical Work ◽  
Self Assembled Monolayers ◽  
Scanning Tunneling ◽  
Assembled Monolayers ◽  
Self Assembled ◽  
Twisting Angle

Inspired by earlier attempts in organic electronics aiming at controlling charge injection from metals into organic materials by manipulating the Schottky energy barrier using self-assembled monolayers (SAMs), recent experimental and theoretical work in molecular electronics showed that metal–organic interfaces can be controlled via changes in the metal work function that are induced by SAMs. In this paper we indicate a different route to achieve interface-driven control over the charge transfer/transport at the molecular scale. It is based on the fact that, in floppy molecule based SAMs, the molecular conformation can be tuned by varying the coverage of the adsorbate. We demonstrate this effect with the aid of benchmark molecules that are often used to fabricate nanojunctions and consist of two rings that can easily rotate relative to each other. We show that, by varying the coverage of the SAM, the twisting angle φ of the considered molecular species can be modified by a factor of two. Given the fact that the low bias conductance G scales as cos2 φ, this results in a change in G of over one order of magnitude for the considered molecular species. Tuning the twisting angle by controlling the SAM coverage may be significant, e.g., for current efforts to fabricate molecular switches. Conversely, the lack of control over the local SAM coverage may be problematic for the reproducibility and interpretation of the STM (scanning tunneling microscope) measurements on repeatedly forming single molecule break junctions.

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