scholarly journals 3D-Plotted Beta-Tricalcium Phosphate Scaffolds with Smaller Pore Sizes Improve In Vivo Bone Regeneration and Biomechanical Properties in a Critical-Sized Calvarial Defect Rat Model

2018 ◽  
Vol 7 (17) ◽  
pp. 1800441 ◽  
Author(s):  
Jingjing Diao ◽  
Jun OuYang ◽  
Ting Deng ◽  
Xiao Liu ◽  
Yanting Feng ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Rat Model ◽  
Tricalcium Phosphate ◽  
Biomechanical Properties ◽  
Calvarial Defect ◽  
Pore Sizes ◽  
Beta Tricalcium Phosphate

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

scholarly journals Bone regeneration of calvarial defect using marine calcareous-derived beta-tricalcium phosphate macrospheres

2014 ◽  
Vol 5 ◽  
pp. 204173141452344 ◽  
Author(s):  
Joshua Chou ◽  
Jia Hao ◽  
Shinji Kuroda ◽  
Besim Ben-Nissan ◽  
Bruce Milthopre ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Beta Tricalcium Phosphate

scholarly journals Dimethyloxaloylglycine-stimulated human bone marrow mesenchymal stem cell-derived exosomes enhance bone regeneration through angiogenesis by targeting the AKT/mTOR pathway

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Bo Liang ◽  
Jia-Ming Liang ◽  
Jia-Ning Ding ◽  
Jia Xu ◽  
Jian-Guang Xu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Regeneration ◽  
Rat Model ◽  
Umbilical Vein ◽  
Tube Formation ◽  
Mtor Pathway ◽  
Calvarial Defect

Abstract Background Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidate agents for treating critical-sized bone defects; they promote angiogenesis and may be an alternative to cell therapy. In this study, we evaluated whether exosomes derived from bone marrow-derived MSCs (BMSCs) preconditioned with a low dose of dimethyloxaloylglycine (DMOG), DMOG-MSC-Exos, exert superior proangiogenic activity in bone regeneration and the underlying mechanisms involved. Methods To investigate the effects of these exosomes, scratch wound healing, cell proliferation, and tube formation assays were performed in human umbilical vein endothelial cells (HUVECs). To test the effects in vivo, a critical-sized calvarial defect rat model was established. Eight weeks after the procedure, histological/histomorphometrical analysis was performed to measure bone regeneration, and micro-computerized tomography was used to measure bone regeneration and neovascularization. Results DMOG-MSC-Exos activated the AKT/mTOR pathway to stimulate angiogenesis in HUVECs. This contributed to bone regeneration and angiogenesis in the critical-sized calvarial defect rat model in vivo. Conclusions Low doses of DMOG trigger exosomes to exert enhanced proangiogenic activity in cell-free therapeutic applications.

Bone Defect Model Dependent Optimal Pore Sizes of 3D‐Plotted Beta‐Tricalcium Phosphate Scaffolds for Bone Regeneration

Small Methods ◽  
2019 ◽  
Vol 3 (11) ◽  
pp. 1900237 ◽  
Author(s):  
Jingjing Diao ◽  
Huanwen Ding ◽  
Minqiang Huang ◽  
Xiaoling Fu ◽  
Fen Zou ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Defect Model ◽  
Pore Sizes ◽  
Beta Tricalcium Phosphate
Sign in / Sign up

Export Citation Format

Share Document