Multicombination Approach SuppressesListeria monocytogenes-Induced Septicemia-Associated Acute Hepatic Failure: The Role of iRhom2 Signaling

2018 ◽  
Vol 7 (17) ◽  
pp. 1800427 ◽  
Author(s):  
Min-Xuan Xu ◽  
Chen-Xu Ge ◽  
Yu-Ting Qin ◽  
Ting-Ting Gu ◽  
De-Shuai Lou ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure

scholarly journals Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Andres F. Carrion ◽  
Frank Czul ◽  
Leopoldo R. Arosemena ◽  
Gennaro Selvaggi ◽  
Monica T. Garcia ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Hepatic Failure ◽  
Hepatic Dysfunction ◽  
Acute Hepatic Failure ◽  
Therapeutic Interventions ◽  
Frequent Monitoring ◽  
Histological Characteristics ◽  
Asymptomatic Elevation

Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.

scholarly journals Paradoxical Role of Matrix Metalloproteinases in Liver Injury and Regeneration after Sterile Acute Hepatic Failure

Cells ◽  
2018 ◽  
Vol 7 (12) ◽  
pp. 247 ◽  
Author(s):  
Débora Alvarenga ◽  
Matheus Mattos ◽  
Mateus Lopes ◽  
Sarah Marchesi ◽  
Alan Araújo ◽  
...  
Keyword(s):  
Liver Injury ◽  
Matrix Metalloproteinases ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Neutrophil Infiltration ◽  
Hepatic Necrosis ◽  
Pharmacological Intervention ◽  
Neutrophil Accumulation ◽  
Drug Induced

Acetaminophen (APAP) poisoning is one of the leading causes of acute hepatic failure and liver transplantation is often the only lifesaving alternative. During the course of hepatocyte necrosis, an intense accumulation of neutrophils is often observed within the liver microenvironment. Despite the classic idea that neutrophil accumulation in tissues causes collateral tissue damage, there is a growing body of evidence showing that neutrophils can also orchestrate the resolution of inflammation. In this work, drug-induced liver injury was induced by oral administration of APAP and pharmacological intervention was made 12 h after this challenge. Liver injury and repair kinetics were evaluated by a novel combination of enzyme quantifications, ELISA, specific antagonists of neutrophil enzymes and confocal intravital microscopy. We have demonstrated that neutrophil infiltration is not only involved in injury amplification, but also in liver tissue repair after APAP-induced liver injury. In fact, while neutrophil depletion led to reduced hepatic necrosis during APAP poisoning, injury recovery was also delayed in neutropenic mice. The mechanisms underlying the neutrophil reparative role involved rapid degranulation and matrix metalloproteinases (MMPs) activity. Our data highlights the crucial role of neutrophils, in particular for MMPs, in the resolution phase of APAP-induced inflammatory response.

scholarly journals Role of Plasmapheresis in the Management of Acute Hepatic Failure in Children

2001 ◽  
Vol 234 (3) ◽  
pp. 418-424 ◽  
Author(s):  
Andrew L. Singer ◽  
Kim M. Olthoff ◽  
Haewon Kim ◽  
Elizabeth Rand ◽  
Gideon Zamir ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure
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