Microparticles Locally Deliver Active Interleukin-1 Receptor Antagonist In Vivo

2018 ◽  
Vol 7 (16) ◽  
pp. 1800263 ◽  
Author(s):  
Anna E. B. Clements ◽  
Emily R. Groves ◽  
Connie S. Chamberlain ◽  
Ray Vanderby ◽  
William L. Murphy
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist

In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy

1997 ◽  
Vol 40 (6) ◽  
pp. 1012-1019 ◽  
Author(s):  
Jean-Pierre Pelletier ◽  
John P. Caron ◽  
Christopher Evans ◽  
Paul D. Robbins ◽  
Helga I. Georgescu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Experimental Osteoarthritis

Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo

1994 ◽  
Vol 50 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Mitsuhiro Tada ◽  
Annie-Claire Diserens ◽  
Isabelle Desbaillets ◽  
Rehana Jaufeerally ◽  
Marie-France Hamou ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Interleukin 1 Receptor Antagonist ◽  
Human Glioblastoma Cells

scholarly journals The interleukin-1 receptor antagonist influences interleukin-1 effects in rat and mouse

1992 ◽  
Vol 1 (1) ◽  
pp. 27-31 ◽  
Author(s):  
P. Bjrök ◽  
K. Ohlsson
Keyword(s):  
Receptor Antagonist ◽  
Acute Phase ◽  
Acute Phase Protein ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Acute Phase Protein Response ◽  
Phase Protein ◽  
Protein Response ◽  
Rats And Mice

In this work we have focused on the ability of interleukin-1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo. The capacity of the interleukin-1 receptor antagonist to influence these events was also investigated. It was shown that interleukin-1 induced an acute phase protein response in rats and mice. In rats α2-macroglubolin levels were increased in plasma after an interleukin-1 injection whereas α1-inhibitor-3 decreased in plasma. In the mice plasma amyloidPwas increased. The interleukin-1 receptor antagonist blocked the increase of α2-macroglobulin and plasma amyloidPin a dose dependent way while the effect on the α1-inhibitor-3 decrease was less pronounced. Interleukin-1 led to polymorphonuclear leukocyte degranulation in vivo as measured by increased cathepsinGplasma levels. The interleukin-1 receptor antagonist could influence the early phase of this degranulation.

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