scholarly journals An Intelligent Neural Stem Cell Delivery System for Neurodegenerative Diseases Treatment

2018 ◽  
Vol 7 (12) ◽  
pp. 1800080 ◽  
Author(s):  
Shupei Qiao ◽  
Yi Liu ◽  
Fengtong Han ◽  
Mian Guo ◽  
Xiaolu Hou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neurodegenerative Diseases ◽  
Neural Stem Cell ◽  
Delivery System ◽  
Cell Delivery ◽  
Stem Cell Delivery

Clinical Potential of Intravenous Neural Stem Cell Delivery for Treatment of Neuroinflammatory Disease in Mice?

2011 ◽  
Vol 20 (6) ◽  
pp. 851-870 ◽  
Author(s):  
Kristien P. Reekmans ◽  
Jelle Praet ◽  
Nathalie De Vocht ◽  
Bart R. Tambuyzer ◽  
Irene Bergwerf ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Delivery ◽  
Neuroinflammatory Disease ◽  
Stem Cell Delivery ◽  
Clinical Potential

scholarly journals A prosurvival and proangiogenic stem cell delivery system to promote ischemic limb regeneration

2016 ◽  
Vol 31 ◽  
pp. 99-113 ◽  
Author(s):  
Yanyi Xu ◽  
Minghuan Fu ◽  
Zhihong Li ◽  
Zhaobo Fan ◽  
Xiaofei Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Delivery System ◽  
Limb Regeneration ◽  
Cell Delivery ◽  
Ischemic Limb ◽  
Stem Cell Delivery

scholarly journals A barrier against reactive oxygen species: chitosan/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Lin ◽  
Xiaoyang Qi ◽  
Wenjing Guo ◽  
Danyang Liang ◽  
Heting Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Delivery System ◽  
Acellular Dermal Matrix ◽  
Cell Delivery ◽  
Stem Cell Therapies ◽  
Dermal Matrix ◽  
Cell Therapies ◽  
Stem Cell Delivery ◽  
Acellular Dermal

Abstract Background Stem cell therapies have gained great attention for providing novel solutions for treatment of various injuries and diseases due to stem cells’ self-renewal, ability to differentiate into various cell types, and favorite paracrine function. Nevertheless, the low retention of transplanted stem cell still limits their clinical applications such as in wound healing in view of an induced harsh microenvironment rich in reactive oxygen species (ROS) during inflammatory reactions. Methods Herein, a novel chitosan/acellular dermal matrix (CHS/ADM) stem cell delivery system is developed, which is of great ROS scavenging activity and significantly attenuates inflammatory response. Result Under ROS microenvironment, this stem cell delivery system acts as a barrier, effectively scavenging an amount of ROS and protecting mesenchymal stem cells (MSCs) from the oxidative stress. It notably regulates intracellular ROS level in MSCs and reduces ROS-induced cellular death. Most importantly, such MSCs delivery system significantly enhances in vivo transplanted stem cell retention, promotes the vessel growth, and accelerates wound healing. Conclusions This novel delivery system, which overcomes the limitations of conventional plain collagen-based delivery system in lacking of ROS-environmental responsive mechanisms, demonstrates a great potential use in stem cell therapies in wound healing.

scholarly journals Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery

Biomaterials ◽  
2018 ◽  
Vol 178 ◽  
pp. 527-545 ◽  
Author(s):  
A.L. Wollenberg ◽  
T.M. O'Shea ◽  
J.H. Kim ◽  
A. Czechanski ◽  
L.G. Reinholdt ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Delivery ◽  
Stem Cell Delivery

Neural stem cell delivery to the spinal cord in an ovine model of fetal surgery for spina bifida

Surgery ◽  
2008 ◽  
Vol 144 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Dario O. Fauza ◽  
Russell W. Jennings ◽  
Yang D. Teng ◽  
Evan Y. Snyder
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Spina Bifida ◽  
Neural Stem Cell ◽  
Fetal Surgery ◽  
Cell Delivery ◽  
Ovine Model ◽  
Stem Cell Delivery
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