scholarly journals Neural Stem Cells: A Dual Functional Scaffold Tethered with EGFR Antibody Promotes Neural Stem Cell Retention and Neuronal Differentiation for Spinal Cord Injury Repair (Adv. Healthcare Mater. 9/2017)

2017 ◽  
Vol 6 (9) ◽  
Author(s):  
Bai Xu ◽  
Yannan Zhao ◽  
Zhifeng Xiao ◽  
Bin Wang ◽  
Hui Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Injury Repair ◽  
Dual Functional ◽  
Cord Injury ◽  
Egfr Antibody

Direct neuronal differentiation of neural stem cells for spinal cord injury repair

Stem Cells ◽  
2021 ◽  
Vol 39 (8) ◽  
pp. 1025-1032 ◽  
Author(s):  
Weiwei Xue ◽  
Caixia Fan ◽  
Bing Chen ◽  
Yannan Zhao ◽  
Zhifeng Xiao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Injury Repair ◽  
Cord Injury

Transplantation of embryonic stem cell-derived neural stem cells for spinal cord injury in adult mice

2005 ◽  
Vol 27 (8) ◽  
pp. 812-819 ◽  
Author(s):  
Hajime Kimura ◽  
Masahide Yoshikawa ◽  
Ryousuke Matsuda ◽  
Hayato Toriumi ◽  
Fumihiko Nishimura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Adult Mice ◽  
Cord Injury

Training Neural Stem Cells on Functional Collagen Scaffolds for Severe Spinal Cord Injury Repair

2016 ◽  
Vol 26 (32) ◽  
pp. 5835-5847 ◽  
Author(s):  
Xing Li ◽  
Sumei Liu ◽  
Yannan Zhao ◽  
Jiayin Li ◽  
Wenyong Ding ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Collagen Scaffolds ◽  
Injury Repair ◽  
Cord Injury

scholarly journals Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries

2021 ◽  
Vol 2 (2) ◽  
pp. 519-537
Author(s):  
Mallesh Kurakula ◽  
Shashank Gorityala ◽  
Devang B. Patel ◽  
Pratap Basim ◽  
Bhaumik Patel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Delivery Systems ◽  
Neural Regeneration ◽  
Therapeutic Effects ◽  
Injury Repair ◽  
Cell Based Therapy ◽  
Cord Injury

Spinal cord injury (SCI) is one of the most complicated nervous system injuries with challenging treatment and recovery. Regenerative biomaterials such as chitosan are being reported for their wide use in filling the cavities, deliver curative drugs, and also provide adsorption sites for transplanted stem cells. Biomaterial scaffolds utilizing chitosan have shown certain therapeutic effects on spinal cord injury repair with some limitations. Chitosan-based delivery in stem cell transplantation is another strategy that has shown decent success. Stem cells can be directed to differentiate into neurons or glia in vitro. Stem cell-based therapy, biopolymer chitosan delivery strategies, and scaffold-based therapeutic strategies have been advancing as a combinatorial approach for spinal cord injury repair. In this review, we summarize the recent progress in the treatment strategies of SCI due to the use of bioactivity of chitosan-based drug delivery systems. An emphasis on the role of chitosan in neural regeneration has also been highlighted.

scholarly journals Rapid and Efficient Differentiation of Rodent Neural Stem Cells into Oligodendrocyte Progenitor Cells

2019 ◽  
Vol 41 (1-2) ◽  
pp. 79-93 ◽  
Author(s):  
Shen Li ◽  
Jiao Zheng ◽  
Linlin Chai ◽  
Mengsi Lin ◽  
Ruocheng Zeng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Progenitor Cells ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Cord Injury

Oligodendrocyte progenitor cells (OPCs) may have beneficial effects in cell replacement therapy of neurodegenerative disease owing to their unique capability to differentiate into myelinogenic oligodendrocytes (OLs) in response to extrinsic signals. Therefore, it is of significance to establish an effective differentiation methodology to generate highly pure OPCs and OLs from some easily accessible stem cell sources. To achieve this goal, in this study, we present a rapid and efficient protocol for oligodendroglial lineage differentiation from mouse neural stem cells (NSCs), rat NSCs, or mouse embryonic stem cell-derived neuroepithelial stem cells. In a defined culture medium containing Smoothened Agonist, basic fibroblast growth factor, and platelet-derived growth factor-AA, OPCs could be generated from the above stem cells over a time course of 4–6 days, achieving a cell purity as high as ∼90%. In particular, these derived OPCs showed high expandability and could further differentiate into myelin basic protein-positive OLs within 3 days or alternatively into glial fibrillary acidic protein-positive astrocytes within 7 days. Furthermore, transplantation of rodent NSC-derived OPCs into injured spinal cord indicated that it is a feasible strategy to treat spinal cord injury. Our results suggest a differentiation strategy for robust production of OPCs and OLs from rodent stem cells, which could provide an abundant OPC source for spinal cord injury.

Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair

2018 ◽  
Vol 6 (2) ◽  
pp. 265-271 ◽  
Author(s):  
Xing Li ◽  
Jianwu Dai
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Collagen Scaffolds ◽  
Neural Repair ◽  
Injury Repair ◽  
Cord Injury ◽  
Cell Source ◽  
Endogenous Neural Stem Cells

Severe spinal cord injury (SCI) induces massive proliferation of spinal cord neural stem cells (NSCs), which are considered a promising cell source for therapeutic neural repair.

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