scholarly journals Nonmineralized and Mineralized Collagen Scaffolds Induce Differential Osteogenic Signaling Pathways in Human Mesenchymal Stem Cells

2017 ◽  
Vol 6 (23) ◽  
pp. 1700641 ◽  
Author(s):  
Qi Zhou ◽  
Xiaoyan Ren ◽  
David Bischoff ◽  
Daniel W. Weisgerber ◽  
Dean T. Yamaguchi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Signaling Pathways ◽  
Human Mesenchymal Stem Cells ◽  
Collagen Scaffolds ◽  
Osteogenic Signaling ◽  
Mineralized Collagen

scholarly journals Nanoparticulate Mineralized Collagen Scaffolds and BMP-9 Induce a Long-Term Bone Cartilage Construct in Human Mesenchymal Stem Cells

2016 ◽  
Vol 5 (14) ◽  
pp. 1821-1830 ◽  
Author(s):  
Xiaoyan Ren ◽  
Daniel W. Weisgerber ◽  
David Bischoff ◽  
Michael S. Lewis ◽  
Russell R. Reid ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Collagen Scaffolds ◽  
Cartilage Construct ◽  
Mineralized Collagen

scholarly journals Adenosine Triphosphate Prevents Serum Deprivation-Induced Apoptosis in Human Mesenchymal Stem Cells via Activation of the MAPK Signaling Pathways

Stem Cells ◽  
2014 ◽  
Vol 33 (1) ◽  
pp. 211-218 ◽  
Author(s):  
Jessica L. Berlier ◽  
Sabrina Rigutto ◽  
Antoine Dalla Valle ◽  
Jessica Lechanteur ◽  
Muhammad S. Soyfoo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Signaling Pathways ◽  
Adenosine Triphosphate ◽  
Human Mesenchymal Stem Cells ◽  
Mapk Signaling ◽  
Serum Deprivation ◽  
Induced Apoptosis ◽  
Mapk Signaling Pathways

Genes that integrate multiple adipogenic signaling pathways in human mesenchymal stem cells

2011 ◽  
Vol 409 (4) ◽  
pp. 786-791 ◽  
Author(s):  
Tomoya Ito ◽  
So Tsuruta ◽  
Koki Tomita ◽  
Kunio Kikuchi ◽  
Takahide Yokoi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Signaling Pathways ◽  
Human Mesenchymal Stem Cells

scholarly journals Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wnt/β-Catenin Signaling Pathways

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Licheng Ni ◽  
Zhihui Kuang ◽  
Zhe Gong ◽  
Deting Xue ◽  
Qiang Zheng
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Signaling Pathways ◽  
Artemisia Annua ◽  
Human Mesenchymal Stem Cells ◽  
Biological Functions ◽  
Low Toxicity ◽  
Underlying Mechanisms ◽  
Important Drug

Dihydroartemisinin (DHA), which is considered to be one of the active compounds within Artemisia annua, has extensively been used in recent years as the most effective drug against malaria, having many biological functions including anticancer, antifungal, and immunomodulatory activities. However, DHA plays a role in the regulation of the proliferation and human mesenchymal stem cells (hMSCs) osteogenic differentiation that remains unknown. We explored DHA’s effect on hMSCs’ proliferation as well as the osteogenic differentiation, together with its underlying mechanisms of action. We showed that DHA enhanced osteogenic differentiation but had no significant effect on hMSCs’ proliferation. It probably exerted its functions through the signaling pathways of ERK1/2 as well as Wnt/β. Because DHA has low toxicity and costs, it might be regarded as an important drug for fracture treatment and tissue engineering.

Sign in / Sign up

Export Citation Format

Share Document