pH-Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real-Time Release Monitoring

2017 ◽  
Vol 6 (19) ◽  
pp. 1700470 ◽  
Author(s):  
Kai Han ◽  
Wei-Yun Zhang ◽  
Jin Zhang ◽  
Zhao-Yu Ma ◽  
He-You Han
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Real Time ◽  
Ph Responsive ◽  
Nanoscale Coordination Polymer

A new type of pH-responsive coordination polymer sphere as a vehicle for targeted anticancer drug delivery and sustained release

2013 ◽  
Vol 1 (25) ◽  
pp. 3202 ◽  
Author(s):  
Peng Fei Gao ◽  
Lin Ling Zheng ◽  
Li Jiao Liang ◽  
Xiao Xi Yang ◽  
Yuan Fang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Sustained Release ◽  
Anticancer Drug ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
New Type ◽  
Polymer Sphere

Taste masking of a drug by pH-responsive coordination polymer-coated mesoporous silica nanoparticles

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 109453-109459 ◽  
Author(s):  
Guang-Ming Bao ◽  
LiQi Wang ◽  
Hou-Qun Yuan ◽  
Xiao-Ying Wang ◽  
Tian-Xiao Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Alimentary Canal ◽  
Oral Drug Delivery ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Taste Masking ◽  
Oral Drug ◽  
Ph Responsive ◽  
Oral Drug Delivery System

We developed a simple and efficient method for fabricating a taste-masked oral drug delivery system (DDS) that regulates the release of unpleasant drug taste via the change in pH value in the physiological environment of the alimentary canal.

Sulfosalicylic acid/Fe3+ based nanoscale coordination polymers for effective cancer therapy by the Fenton reaction: an inspiration for understanding the role of aspirin in the prevention of cancer

2019 ◽  
Vol 7 (12) ◽  
pp. 5482-5491 ◽  
Author(s):  
Qianqian Liu ◽  
Keke Du ◽  
Mei Liu ◽  
Rongmu Lv ◽  
Baiwang Sun ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Coordination Polymer ◽  
Fenton Reaction ◽  
Ph Responsive ◽  
Sulfosalicylic Acid ◽  
New Type ◽  
Prevention Of Cancer ◽  
Nanoscale Coordination Polymer ◽  
Effective Cancer Therapy

A new type of pH-responsive nanoscale coordination polymer for ROS-enhanced cancer therapy.

Coordination polymer nanocapsules prepared using metal–organic framework templates for pH-responsive drug delivery

2017 ◽  
Vol 28 (27) ◽  
pp. 275601 ◽  
Author(s):  
Lei Tang ◽  
Jiafu Shi ◽  
Xiaoli Wang ◽  
Shaohua Zhang ◽  
Hong Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Organic Framework

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery

2021 ◽  
Author(s):  
Yifan Zhang ◽  
Xueying Peng ◽  
Xinbo Jing ◽  
Lin Cui ◽  
Shengchao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Composite ◽  
Ph Responsive
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