scholarly journals Europium-Doped Cerium Oxide Nanoparticles Limit Reactive Oxygen Species Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury

2017 ◽  
Vol 6 (14) ◽  
pp. 1700176 ◽  
Author(s):  
Ekaterina O. Gubernatorova ◽  
Xiaobo Liu ◽  
Ali Othman ◽  
Wayne T. Muraoka ◽  
Ekaterina P. Koroleva ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Reactive Oxygen Species Formation ◽  
Species Formation ◽  
Intestinal Ischemia Reperfusion

scholarly journals Modulatory Effect of Myokines on Reactive Oxygen Species in Ischemia/Reperfusion

2020 ◽  
Vol 21 (24) ◽  
pp. 9382
Author(s):  
Márton Richárd Szabó ◽  
Márton Pipicz ◽  
Tamás Csont ◽  
Csaba Csonka
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Interleukin 7 ◽  
Species Formation

There is a growing body of evidence showing the importance of physical activity against acute ischemic events in various organs. Ischemia/reperfusion injury (I/R) is characterized by tissue damage as a result of restriction and subsequent restoration of blood supply to an organ. Oxidative stress due to increased reactive oxygen species formation and/or insufficient antioxidant defense is considered to play an important role in I/R. Physical activity not only decreases the general risk factors for ischemia but also confers direct anti-ischemic protection via myokine production. Myokines are skeletal muscle-derived cytokines, representing multifunctional communication channels between the contracting skeletal muscle and other organs through an endocrine manner. In this review, we discuss the most prominent members of the myokines (i.e., brain-derived neurotrophic factor (BDNF), cathepsin B, decorin, fibroblast growth factors-2 and -21, follistatin, follistatin-like, insulin-like growth factor-1; interleukin-6, interleukin-7, interleukin-15, irisin, leukemia inhibitory factor, meteorin-like, myonectin, musclin, myostatin, and osteoglycin) with a particular interest in their potential influence on reactive oxygen and nitrogen species formation or antioxidant capacity. A better understanding of the mechanism of action of myokines and particularly their participation in the regulation of oxidative stress may widen their possible therapeutic use and, thereby, may support the fight against I/R.

Human neutrophils ROS inhibition and protective effects of Myrtus communis leaves essential oils against intestinal ischemia/reperfusion injury

RSC Advances ◽  
2016 ◽  
Vol 6 (20) ◽  
pp. 16645-16655 ◽  
Author(s):  
Mohamed-Amine Jabri ◽  
Soumaya Hajaji ◽  
Lamjed Marzouki ◽  
Jamel El-Benna ◽  
Mohsen Sakly ◽  
...  
Keyword(s):  
Essential Oils ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Human Neutrophils ◽  
Ros Production ◽  
Oxygen Species ◽  
Protective Effects ◽  
Myrtus Communis ◽  
Intestinal Ischemia Reperfusion

The aim of the present work was to investigate the mechanism implicated in the protective effects ofMyrtus communisleaves essential oils (MCEO) on human neutrophils reactive oxygen species (ROS) production.

scholarly journals Antioxidant-Based Therapy Reduces Early-Stage Intestinal Ischemia-Reperfusion Injury in Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 853
Author(s):  
Gaizka Gutiérrez-Sánchez ◽  
Ignacio García-Alonso ◽  
Jorge Gutiérrez Sáenz de Santa María ◽  
Ana Alonso-Varona ◽  
Borja Herrero de la Parte
Keyword(s):  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Molecular Mechanisms ◽  
Ischemia Reperfusion Injury ◽  
Early Stage ◽  
Ischemia Reperfusion ◽  
Mucosal Damage ◽  
Intestinal Damage ◽  
Oxygen Species ◽  
Intestinal Ischemia Reperfusion

Intestinal ischemia-reperfusion injury (i-IRI) is a rare disorder with a high mortality rate, resulting from the loss of blood flow to an intestinal segment. Most of the damage is triggered by the restoration of flow and the arrival of cytokines and reactive oxygen species (ROS), among others. Inactivation of these molecules before tissue reperfusion could reduce intestinal damage. The aim of this work was to analyze the preventive effect of allopurinol and nitroindazole on intestinal mucosal damage after i-IRI. Wag/RijHsd rats were subjected to i-IRI by clamping the superior mesenteric artery (for 1 or 2 h) followed by a 30 min period of reperfusion. Histopathological intestinal damage (HID) was assessed by microscopic examination of histological sections obtained from injured intestine. HID was increased by almost 20% by doubling the ischemia time (from 1 to 2 h). Nitroindazole reduced HID in both the 1 and 2 h period of ischemia by approximately 30% and 60%, respectively (p < 0.001). Our preliminary results demonstrate that nitroindazole has a preventive/protective effect against tissue damage in the early stages of i-IRI. However, to better understand the molecular mechanisms underlying this phenomenon, further studies are needed.

Role of JNK phosphorylation in intestinal ischemia/reperfusion injury in mice

2010 ◽  
Vol 30 (2) ◽  
pp. 140-143
Author(s):  
De-yi ZHENG ◽  
Jian-ming WNAG ◽  
Yi-tao JIA ◽  
Jin-feng FU ◽  
Kai-yang LU ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion
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