scholarly journals Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy

2016 ◽  
Vol 5 (22) ◽  
pp. 2882-2895 ◽  
Author(s):  
Maneesh Gujrati ◽  
Amita M. Vaidya ◽  
Margaret Mack ◽  
Dayton Snyder ◽  
Anthony Malamas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Ph Sensitive ◽  
Paclitaxel Resistance ◽  
Breast Cancer Therapy

A pH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy

2015 ◽  
Vol 3 (22) ◽  
pp. 4514-4523 ◽  
Author(s):  
Zeng-Ying Qiao ◽  
Di Zhang ◽  
Chun-Yuan Hou ◽  
Si-Meng Zhao ◽  
Ya Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Ph Sensitive ◽  
Drug Formulation ◽  
Ph Responsive ◽  
Breast Cancer Therapy

The co-encapsulation of RA-V cyclopeptide and SQ molecules in pH-sensitive PAE micelles for efficient tumor therapy and imaging in vitro and in vivo.

Efficient in vitro and in vivo docetaxel delivery mediated by pH-sensitive LPHNPs for effective breast cancer therapy

2021 ◽  
Vol 203 ◽  
pp. 111760
Author(s):  
Rajesh Singh Jadon ◽  
Gajanand Sharma ◽  
Neeraj K. Garg ◽  
Nikunj Tandel ◽  
Kavita R. Gajbhiye ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Ph Sensitive ◽  
Breast Cancer Therapy

scholarly journals Co-delivery of dihydroartemisinin and docetaxel in pH-sensitive nanoparticles for treating metastatic breast cancerviathe NF-κB/MMP-2 signal pathway

RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21735-21744 ◽  
Author(s):  
Jin Tao ◽  
Zeng Tan ◽  
Lu Diao ◽  
Zhonghua Ji ◽  
Jiahuan Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Therapy ◽  
Synergistic Effects ◽  
Metastatic Breast ◽  
Signal Pathway ◽  
Ph Sensitive ◽  
Breast Cancer Therapy

Co-delivery DTX and DHA as acid-sensitive nanoparticles to exert synergistic effects for metastatic breast cancer therapy.

scholarly journals Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy

2019 ◽  
Vol 20 (19) ◽  
pp. 4671
Author(s):  
Hoon Hyun ◽  
Young Yoo ◽  
So Kim ◽  
Hyun Ko ◽  
Heung Chun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Anticancer Effect ◽  
Breast Cancer Therapy ◽  
Glycol Chitosan ◽  
Burst Period ◽  
Delivery Approach ◽  
Dual Drug

We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 days and remained so thereafter. After an initial burst period of 7 hours, the two drugs were released in a sustained manner for 7 days. The in vitro cell viability test showed that GDCP had a better anticancer effect than well plate and DOX⋅HCl/PTX (DP). In addition, the in vivo tests, which evaluated the anticancer effect, systemic toxicity, and histology, proved the feasibility of GDCP as a clinical therapy for breast cancer.

Estrogen-Anchored pH-Sensitive Liposomes as Nanomodule Designed for Site-Specific Delivery of Doxorubicin in Breast Cancer Therapy

2011 ◽  
Vol 9 (1) ◽  
pp. 176-186 ◽  
Author(s):  
Shivani R. Paliwal ◽  
Rishi Paliwal ◽  
Harish C. Pal ◽  
Ajeet K. Saxena ◽  
Pradyumana R. Sharma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Ph Sensitive ◽  
Breast Cancer Therapy ◽  
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