scholarly journals Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

2016 ◽  
Vol 6 (1) ◽  
pp. 1600550 ◽  
Author(s):  
Dario L. Longo ◽  
Rachele Stefania ◽  
Chiara Callari ◽  
Francesco De Rose ◽  
Riccardo Rolle ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Antiangiogenic Therapy ◽  
Tumor Vasculature ◽  
Water Soluble ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Dynamic contrast-enhanced photoacoustic imaging using photothermal stimuli-responsive composite nanomodulators

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Yun-Sheng Chen ◽  
Soon Joon Yoon ◽  
Wolfgang Frey ◽  
Mary Dockery ◽  
Stanislav Emelianov
Keyword(s):  
Photoacoustic Imaging ◽  
Stimuli Responsive ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Metastatic Renal Carcinoma: Evaluation of Antiangiogenic Therapy with Dynamic Contrast-enhanced CT

Radiology ◽  
2010 ◽  
Vol 256 (2) ◽  
pp. 511-518 ◽  
Author(s):  
Laure S. Fournier ◽  
Stephane Oudard ◽  
Rokhaya Thiam ◽  
Ludovic Trinquart ◽  
Eugeniu Banu ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Antiangiogenic Therapy ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct ◽  
Dynamic Contrast Enhanced Ct

Early Quantitative Evaluation of a Tumor Vasculature Disruptive Agent AVE8062 Using Dynamic Contrast-Enhanced Ultrasonography

2008 ◽  
Vol 43 (2) ◽  
pp. 100-111 ◽  
Author(s):  
Sonia Lavisse ◽  
Pascale Lejeune ◽  
Valérie Rouffiac ◽  
Nicolas Elie ◽  
Estelle Bribes ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Tumor Vasculature ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

scholarly journals Integrin αvβ3–Targeted Dynamic Contrast–Enhanced Magnetic Resonance Imaging Using a Gadolinium-Loaded Polyethylene Gycol–Dendrimer–Cyclic RGD Conjugate to Evaluate Tumor Angiogenesis and to Assess Early Antiangiogenic Treatment Response in a Mouse Xenograft Tumor Model

2012 ◽  
Vol 11 (4) ◽  
pp. 7290.2011.00050 ◽  
Author(s):  
Wei-Tsung Chen ◽  
Tiffany Ting Fang Shih ◽  
Ran-Chou Chen ◽  
Shin-Yang Tu ◽  
Hsieh Wen-Yuen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Angiogenesis ◽  
Antiangiogenic Therapy ◽  
Resonance Imaging ◽  
Antiangiogenic Treatment ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Bevacizumab Treatment ◽  
Contrast Enhanced

The purpose of this study was to validate an integrin αvβ3–targeted magnetic resonance contrast agent, PEG-G3-(Gd-DTPA)6-(cRGD-DTPA)2, for its ability to detect tumor angiogenesis and assess early response to antiangiogenic therapy using dynamic contrast–enhanced (DCE) magnetic resonance imaging (MRI). Integrin αvβ3–positive U87 cells and control groups were incubated with fluorescein-labeled cRGD-conjugated dendrimer, and the cellular attachment of the dendrimer was observed. DCE MRI was performed on mice bearing KB xenograft tumors using either PEG-G3-(Gd-DTPA)6-(cRGD-DTPA)2 or PEG-G3-(Gd-DTPA)6-(cRAD-DTPA)2. DCE MRI was also performed 2 hours after anti–integrin αvβ3 monoclonal antibody treatment and after bevacizumab treatment on days 3 and 6t. Using DCE MRI, the 30-minute contrast washout percentage was significantly lower in the cRGD-conjugate injection groups. The enhancement patterns were different between the two contrast injection groups. In the antiangiogenic therapy groups, a rapid increase in 30-minute contrast washout percentage was observed in both the LM609 and bevacizumab treatment groups, and this occurred before there was an observable decrease in tumor size. The integrin αvβ3 targeting ability of PEG-G3-(Gd-DTPA)6-(cRGD-DTPA)2 in vitro and in vivo was demonstrated. The 30-minute contrast washout percentage is a useful parameter for examining tumor angiogenesis and for the early assessment of antiangiogenic treatment response.

Pancreatic Cancer: Utility of Dynamic Contrast-enhanced MR Imaging in Assessment of Antiangiogenic Therapy

Radiology ◽  
2010 ◽  
Vol 256 (2) ◽  
pp. 441-449 ◽  
Author(s):  
M. Fatih Akisik ◽  
Kumaresan Sandrasegaran ◽  
Guixue Bu ◽  
Chen Lin ◽  
Gary D. Hutchins ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mr Imaging ◽  
Antiangiogenic Therapy ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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