scholarly journals Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation

2015 ◽  
Vol 4 (12) ◽  
pp. 1826-1832 ◽  
Author(s):  
Ruijing Guo ◽  
Sichang Lu ◽  
Jonathan M. Page ◽  
Alyssa R. Merkel ◽  
Sandip Basu ◽  
...  
Keyword(s):  
Pore Size ◽  
Osteogenic Differentiation ◽  
Fused Deposition Modeling ◽  
3D Scaffolds ◽  
Fused Deposition ◽  
Deposition Modeling

scholarly journals Inverse 3D Printing with Variations of the Strand Width of the Resulting Scaffolds for Bone Replacement

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1964
Author(s):  
Michael Seidenstuecker ◽  
Pia Schilling ◽  
Lucas Ritschl ◽  
Svenja Lange ◽  
Hagen Schmal ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Pore Size ◽  
Fused Deposition Modeling ◽  
Experimental Period ◽  
Fused Deposition ◽  
A Value ◽  
Significant Difference ◽  
Strand Spacing ◽  
Deposition Modeling ◽  
Good Biocompatibility

The objective of this study was to vary the wall thicknesses and pore sizes of inversely printed 3D molded bodies. Wall thicknesses were varied from 1500 to 2000 to 2500 µm. The pores had sizes of 500, 750 and 1000 µm. The sacrificial structures were fabricated from polylactide (PLA) using fused deposition modeling (FDM). To obtain the final bioceramic scaffolds, a water-based slurry was filled into the PLA molds. The PLA sacrificial molds were burned out at approximately 450 °C for 4 h. Subsequently, the samples were sintered at 1250 °C for at least 4 h. The scaffolds were mechanically characterized (native and after incubation in simulated body fluid (SBF) for 28 days). In addition, the biocompatibility was assessed by live/dead staining. The scaffolds with a strand spacing of 500 µm showed the highest compressive strength; there was no significant difference in compressive strength regardless of pore size. The specimens with 1000 µm pore size showed a significant dependence on strand width. Thus, the specimens (1000 µm pores) with 2500 µm wall thickness showed the highest compressive strength of 5.97 + 0.89 MPa. While the 1000(1500) showed a value of 2.90 + 0.67 MPa and the 1000(2000) of 3.49 + 1.16 MPa. As expected for beta-Tricalciumphosphate (β-TCP), very good biocompatibility was observed with increasing cell numbers over the experimental period.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

An Update on the Use of Alginate in Additive Biofabrication Techniques

2019 ◽  
Vol 25 (11) ◽  
pp. 1249-1264 ◽  
Author(s):  
Amoljit Singh Gill ◽  
Parneet Kaur Deol ◽  
Indu Pal Kaur
Keyword(s):  
Fused Deposition Modeling ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Layer By Layer ◽  
Three Dimension ◽  
Anionic Polymer ◽  
Fused Deposition ◽  
The Status ◽  
Deposition Modeling ◽  
Extrusion Printing

Background: Solid free forming (SFF) technique also called additive manufacturing process is immensely popular for biofabrication owing to its high accuracy, precision and reproducibility. Method: SFF techniques like stereolithography, selective laser sintering, fused deposition modeling, extrusion printing, and inkjet printing create three dimension (3D) structures by layer by layer processing of the material. To achieve desirable results, selection of the appropriate technique is an important aspect and it is based on the nature of biomaterial or bioink to be processed. Result & Conclusion: Alginate is a commonly employed bioink in biofabrication process, attributable to its nontoxic, biodegradable and biocompatible nature; low cost; and tendency to form hydrogel under mild conditions. Furthermore, control on its rheological properties like viscosity and shear thinning, makes this natural anionic polymer an appropriate candidate for many of the SFF techniques. It is endeavoured in the present review to highlight the status of alginate as bioink in various SFF techniques.

Recent Advance on Fused Deposition Modeling

2014 ◽  
Vol 7 (2) ◽  
pp. 122-130 ◽  
Author(s):  
Zhe Shi ◽  
Yonggang Peng ◽  
Wei Wei
Keyword(s):  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Deposition Modeling
Sign in / Sign up

Export Citation Format

Share Document