Capture, Enrichment, and Mass Spectrometric Detection of Low-Molecular-Weight Biomarkers with Nanoporous Silicon Microparticles

2012 ◽  
Vol 1 (6) ◽  
pp. 742-750 ◽  
Author(s):  
Jie Tan ◽  
Wei-Jie Zhao ◽  
Jie-Kai Yu ◽  
Sai Ma ◽  
Michael J. Sailor ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Low Molecular Weight ◽  
Nanoporous Silicon

scholarly journals Integrated microfluidic aptasensor for mass spectrometric detection of vasopressin in human plasma ultrafiltrate

2016 ◽  
Vol 8 (26) ◽  
pp. 5190-5196 ◽  
Author(s):  
J. Yang ◽  
J. Zhu ◽  
R. Pei ◽  
J. A. Oliver ◽  
D. W. Landry ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Human Plasma ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Low Molecular Weight ◽  
Plasma Ultrafiltrate

We present a microfluidic aptamer-based biosensor for detection of low-molecular-weight biomarkers in patient samples.

Gas-Chromatographic and Mass-Spectrometric Detection of Low-Molecular-Weight Aliphatic Alcohols in Urine of Normal Individuals and Patients with Diabetes Mellitus

1975 ◽  
Vol 21 (9) ◽  
pp. 1294-1296 ◽  
Author(s):  
Hartmut M Liebich ◽  
Ossama Al-Babbili ◽  
Albert Zlatkis ◽  
Kyoung Kim
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Weight ◽  
Urinary Metabolites ◽  
Mass Spectrometric ◽  
Aliphatic Alcohols ◽  
Porous Polymer ◽  
Low Molecular Weight ◽  
Primary Alcohols ◽  
Special Diet ◽  
Patients With Diabetes

Abstract We studied the aliphatic alcohols in 100 urines from 25 patients with diabetes mellitus under treatment with insulin, oral antidiabetic medication, or special diet. The procedure involves adsorption of the low-molecular-weight urinary metabolites on a porous polymer of 2,6-diphenyl-p-phenylene oxide (Tenax GC), gas-chromatographic separation, mass spectrometric identification, and mass fragmentographic representation of the primary alcohols by a computer. The concentrations of ethanol, n-propanol, isobutanol, n-butanol, and isopentanol are increased as compared with urine from normal persons.

Mass spectrometric characteristics and preliminary figures of merit for polyaromatic hydrocarbons via the liquid sampling-atmospheric pressure glow discharge microplasma

2020 ◽  
Vol 35 (11) ◽  
pp. 2475-2478
Author(s):  
Tyler J. Williams ◽  
Jacob R. Bills ◽  
R. Kenneth Marcus
Keyword(s):  
Molecular Weight ◽  
Atmospheric Pressure ◽  
Polyaromatic Hydrocarbons ◽  
Mass Spectrometric ◽  
Low Molecular Weight ◽  
Atmospheric Pressure Glow Discharge ◽  
Figures Of Merit ◽  
Ionization Mechanisms ◽  
Pressure Glow Discharge ◽  
Polar Low

The versatility of the LS-APGD microplasma is extended beyond elemental and polar molecular species to non-polar, low molecular weight polyaromatic hydrocarbons. Insights into ionization mechanisms are gained, with preliminary LODs determined.

Mass spectrometric characterization of membrane integral low molecular weight proteins from photosystem II in barley etioplasts

PROTEOMICS ◽  
2009 ◽  
Vol 9 (3) ◽  
pp. 625-635 ◽  
Author(s):  
Matthias Plöscher ◽  
Bernhard Granvogl ◽  
Mikael Zoryan ◽  
Veronika Reisinger ◽  
Lutz Andreas Eichacker
Keyword(s):  
Molecular Weight ◽  
Photosystem Ii ◽  
Mass Spectrometric ◽  
Low Molecular Weight ◽  
Low Molecular Weight Proteins

scholarly journals Inferences on the Nature of a Cr(V) or Cr(IV) Species Formed by Reduction of Dichromate by a Bovine Liver Homogenate: NMR and Mass-Spectrometric Studies

2003 ◽  
Vol 1 (3-4) ◽  
pp. 285-298 ◽  
Author(s):  
Elena Gaggelli ◽  
Nicola D'Amelio ◽  
Nicola Gaggelli ◽  
Gianni Valensin ◽  
Lucia Bovalini ◽  
...  
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Diffusion Coefficient ◽  
Liver Homogenate ◽  
Bovine Liver ◽  
Mass Spectrometric ◽  
Low Molecular Weight ◽  
Nmr Spectrum ◽  
H Nmr ◽  
Molecular Masses

A low-molecular weight chromium-containing fraction of the material resulting from dichromate reduction by bovine liver homogenate was investigated by NMR and ES-MS. The ES-MS spectrum showed a readily detectable peak at m/z = 786.1. The same molecular weight reasonably agreed with the relatively low diffusion coefficient measured by NMR-DOSY experiments on the main species observed in the1H NMR spectrum. At least two downfield shifted and broad paramagnetic signals were apparent in the1H NMR spectrum. Temperature dependence of chemical shift was exploited in order to estimate the diamagnetic shift of the signals in the diamagnetic region of the spectrum. 2D TOCSY, NOESY, COSY and1H-3C HMQC spectra revealed the presence of aromatic protons (which were assigned as His residues), Gly and some other short chain amino-acids. Combinations of the molecular masses of such components together with acetate (which is present in the solution) and chromium atoms allowed a tentative proposal of a model for the compound.

Mass spectrometric techniques for characterizing low-molecular-weight resins used as paint varnishes

2012 ◽  
Vol 405 (2-3) ◽  
pp. 1047-1065 ◽  
Author(s):  
I. Bonaduce ◽  
M. P. Colombini ◽  
I. Degano ◽  
F. Di Girolamo ◽  
J. La Nasa ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Mass Spectrometric ◽  
Low Molecular Weight ◽  
Mass Spectrometric Techniques
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