Near‐Infrared II Plasmonic Au@Au–Ag Dot‐in‐Cubic Nanoframes for In Vivo Surface‐Enhanced Raman Spectroscopic Detection and Photoacoustic Imaging

2021 ◽  
pp. 2103186
Author(s):  
Beibei Shan ◽  
Linhu Li ◽  
Yawen Zhao ◽  
Haitao Wang ◽  
Ming Li
Keyword(s):  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Raman Spectroscopic ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Multicore Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo

ACS Nano ◽  
2021 ◽  
Author(s):  
Jung Ho Yu ◽  
Idan Steinberg ◽  
Ryan M. Davis ◽  
Andrey V. Malkovskiy ◽  
Aimen Zlitni ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo

2020 ◽  
Author(s):  
Jung-Ho Yu ◽  
Idan Steinberg ◽  
Ryan Miller Davis ◽  
Andrey V. Malkovskiy ◽  
Aimen Zlitni ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Ex Vivo ◽  
Spectral Width ◽  
Raman Imaging ◽  
Multiple Tumor ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Longitudinal Imaging

In vivo multiplexed imaging aims for noninvasive analysis of multiple tumor biomarkers. While most of the preclinical imaging has provided a number of multiplexing channels up to three, Raman imaging with surface-enhanced Raman scattering (SERS) nanoparticles was suggested to offer higher multiplexing capability originating from their narrow spectral width. However, the multiplexed Raman imaging is still in its infancy for visualizing tumors with both sufficient multiplicity and high sensitivity concurrently. Here we create multispectral palettes of gold core-near-infrared (NIR) resonant Raman dyes-silica shell SERS (NIR-SERRS) nanoparticles, which provide both the high multiplicity and fluorescence-comparable sensitivity. With the NIR-SERRS nanoparticle palettes, we demonstrate noninvasive and five-plex ratiometric Raman imaging of tumors in living mice. Furthermore, we perform noninvasive and longitudinal imaging of the five-color nanoparticles in the tumors, which is not feasible with current ex vivo multiplexing platforms, demonstrating great potential for noninvasive assessment of multiple biological targets within tumors.

scholarly journals General and programmable synthesis of hybrid liposome/metal nanoparticles

2016 ◽  
Vol 2 (12) ◽  
pp. e1601838 ◽  
Author(s):  
Jin-Ho Lee ◽  
Yonghee Shin ◽  
Wooju Lee ◽  
Keumrai Whang ◽  
Dongchoul Kim ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Colloidal Stability ◽  
Near Infrared ◽  
Surface Enhanced Raman Spectroscopy ◽  
Au Nanoparticle ◽  
Intracellular Imaging ◽  
Biologically Relevant ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Hybrid liposome/metal nanoparticles are promising candidate materials for biomedical applications. However, the poor selectivity and low yield of the desired hybrid during synthesis pose a challenge. We designed a programmable liposome by selective encoding of a reducing agent, which allows self-crystallization of metal nanoparticles within the liposome to produce stable liposome/metal nanoparticles alone. We synthesized seven types of liposome/monometallic and more complex liposome/bimetallic hybrids. The resulting nanoparticles are tunable in size and metal composition, and their surface plasmon resonance bands are controllable in visible and near infrared. Owing to outer lipid bilayer, our liposome/Au nanoparticle shows better colloidal stability in biologically relevant solutions as well as higher endocytosis efficiency than gold nanoparticles without the liposome. We used this hybrid in intracellular imaging of living cells via surface-enhanced Raman spectroscopy, taking advantage of its improved physicochemical properties. We believe that our method greatly increases the utility of metal nanoparticles in in vivo applications.

scholarly journals Novel near-infrared and Raman spectroscopic technologies for print and photography identification, classification, and authentication

NIR news ◽  
2021 ◽  
Vol 32 (1-2) ◽  
pp. 11-16
Author(s):  
Justyna Grabska ◽  
Krzysztof B Beć ◽  
Christian W Huck
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Spectroscopic Techniques ◽  
Raman Spectroscopic ◽  
Current State ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Portable Instruments ◽  
Enhanced Raman Scattering

Modern forensics encounters new challenges and demands new analytical methods that would meet variety of prerequisites regarding their accuracy, rapidness, flexibility, and reliability. Vibrational spectroscopic methods, in particular near-infrared spectroscopy, offer such potential and meet an increasing interest in forensics for authentication of various documents. Pittcon 2020 Conference, which took place in Chicago, Illinois, included a Session dedicated to the role of novel tools of investigation in the forensics of tomorrow. This article summarizes and complements the presentation upon how the current state-of-the-art and future prospects of vibrational spectroscopic techniques fits into this role. The application of near-infrared spectroscopy, including the benefits stemming from using novel miniaturized portable instruments, Raman and surface-enhanced Raman scattering techniques, is discussed in detail in the present article.

scholarly journals Silica-Coated, Waxberry-like Surface-Enhanced Raman Resonant Scattering Tag-Pair with Near-Infrared Raman Dye Encoding: Toward In Vivo Duplexing Detection

2020 ◽  
Vol 92 (21) ◽  
pp. 14814-14821
Author(s):  
Yingchao Yin ◽  
Rongchao Mei ◽  
Yunqing Wang ◽  
Xizhen Zhao ◽  
Qian Yu ◽  
...  
Keyword(s):  
Near Infrared ◽  
Resonant Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo

2020 ◽  
Author(s):  
Jung-Ho Yu ◽  
Idan Steinberg ◽  
Ryan Miller Davis ◽  
Andrey V. Malkovskiy ◽  
Aimen Zlitni ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Ex Vivo ◽  
Spectral Width ◽  
Raman Imaging ◽  
Multiple Tumor ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Longitudinal Imaging

In vivo multiplexed imaging aims for noninvasive analysis of multiple tumor biomarkers. While most of the preclinical imaging has provided a number of multiplexing channels up to three, Raman imaging with surface-enhanced Raman scattering (SERS) nanoparticles was suggested to offer higher multiplexing capability originating from their narrow spectral width. However, the multiplexed Raman imaging is still in its infancy for visualizing tumors with both sufficient multiplicity and high sensitivity concurrently. Here we create multispectral palettes of gold core-near-infrared (NIR) resonant Raman dyes-silica shell SERS (NIR-SERRS) nanoparticles, which provide both the high multiplicity and fluorescence-comparable sensitivity. With the NIR-SERRS nanoparticle palettes, we demonstrate noninvasive and five-plex ratiometric Raman imaging of tumors in living mice. Furthermore, we perform noninvasive and longitudinal imaging of the five-color nanoparticles in the tumors, which is not feasible with current ex vivo multiplexing platforms, demonstrating great potential for noninvasive assessment of multiple biological targets within tumors.

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