Comparison of Ionic Liquids and Chemical Permeation Enhancers for Transdermal Drug Delivery

2020 ◽  
Vol 30 (45) ◽  
pp. 2004257
Author(s):  
Qin M. Qi ◽  
Miya Duffy ◽  
Alex M. Curreri ◽  
Joel P. R. Balkaran ◽  
Eden E. L. Tanner ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

scholarly journals Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 96 ◽  
Author(s):  
Zainul Sidat ◽  
Thashree Marimuthu ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
Pierre P.D. Kondiah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Therapeutic Benefits ◽  
Chemical Permeation Enhancers ◽  
Cytotoxicity Studies ◽  
Transdermal Drug Delivery Systems ◽  
Routes Of Drug Administration ◽  
Drug Modification

Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and favorable cytotoxicity studies, ILs were shown to be a possible solution to overcome these challenges. Their favorable application in overcoming challenges ranging from synthesis, manufacture, and even therapeutic benefits were documented. In this review, said ILs are highlighted and their role in TDDS is reviewed in terms of (a) ILs as permeation enhancers (single agents or combined), (b) ILs in drug modification, and (c) ILs as active pharmaceutical ingredients. Furthermore, future combination of ILs with other chemical permeation enhancers (CPEs) is proposed and discussed.

scholarly journals Novel chemical permeation enhancers for transdermal drug delivery

2014 ◽  
Vol 9 (2) ◽  
pp. 51-64 ◽  
Author(s):  
Yang Chen ◽  
Peng Quan ◽  
Xiaochang Liu ◽  
Manli Wang ◽  
Liang Fang
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

scholarly journals A Review on Chemical Permeation Enhancers used in the Formulation of Transdermal Drug Delivery System

2021 ◽  
pp. 429-437
Author(s):  
. Shivani ◽  
Ritika Puri
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Free Water ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Penetration Enhancers ◽  
Permeation Enhancers ◽  
Transdermal Drug Delivery System ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

Skin penetration enhancement technology is a rapidly evolving area that will greatly increase the quantity of transdermal drug delivery medications. Penetration enhancers are used to facilitate the movement of drugs through the skin barrier. Numerous methods exist for extending partition enhancement. The enhancers' contact with the polar head of the lipid groups is the potential means for increasing the penetration. Penetration enhancers improve the amount of free water molecules between the bilayer, leading to an improvement of the polar drug diffusion cross section. This article focuses on the different compounds assessed for improving penetration activity like sulphoxides, azones, pyrrolidones, alcohols and alkanols, glycols, surfactants and terpenes.

scholarly journals Design, Synthesis of Novel Lipids as Chemical Permeation Enhancers and Development of Nanoparticle System for Transdermal Drug Delivery

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82581 ◽  
Author(s):  
Srujan Marepally ◽  
Cedar H. A. Boakye ◽  
Punit P. Shah ◽  
Jagan Reddy Etukala ◽  
Adithi Vemuri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Design Synthesis ◽  
Chemical Permeation Enhancers ◽  
Nanoparticle System ◽  
Chemical Permeation

scholarly journals Transmucosal Absorption Enhancers in the Drug Delivery Field

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 339 ◽  
Author(s):  
Maher ◽  
Casettari ◽  
Illum
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Delivery Systems ◽  
Permeation Enhancer ◽  
Special Issue ◽  
Permeation Enhancers ◽  
Absorption Enhancers ◽  
Chemical Permeation Enhancers ◽  
Epithelial Barriers ◽  
Chemical Permeation

Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely tested approaches to improve transmucosal permeability via oral, nasal, buccal, ocular and pulmonary routes. To date, only a small number of permeation enhancers have progressed to clinical trials, and only one product that includes a permeation enhancer has reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field (https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers). The guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancers in the drug delivery field.

Skin Permeation of Nanoparticles: Mechanisms Involved and Critical Factors Governing Topical Drug Delivery

2020 ◽  
Vol 26 (36) ◽  
pp. 4601-4614
Author(s):  
Taha Umair Wani ◽  
Roohi Mohi-ud-Din ◽  
Asmat Majeed ◽  
Shabnam Kawoosa ◽  
Faheem Hyder Pottoo
Keyword(s):  
Drug Delivery ◽  
Skin Permeation ◽  
Complex Structure ◽  
Osmotic Gradient ◽  
Critical Factors ◽  
Permeation Enhancers ◽  
Vast Number ◽  
Factors Affecting ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

Transdermal route has been an ever sought-after means of drug administration, regarded as being the most convenient and patient compliant. However, skin poses a great barrier to the entry of the external particles including bacteria, viruses, allergens, and drugs as well (mostly hydrophilic or high molecular weight drugs), consequent to its complex structure and composition. Among the various means of enhancing drug permeation through the skin, e.g. chemical permeation enhancers, electroporation, thermophoresis, etc. drug delivery through nanoparticles has been of great interest. Current literature reports a vast number of nanoparticles that have been implicated for drug delivery through the skin. However, a precise account of critical factors involved in drug delivery and mechanisms concerning the permeation of nanoparticles through the skin is necessary. The purpose of this review is to enumerate the factors crucial in governing the prospect of drug delivery through skin and classify the skin permeation mechanisms of nanoparticles. Among the various mechanisms discussed are the ones governed by principles of kinetics, osmotic gradient, adhesion, hydration, diffusion, occlusion, electrostatic interaction, thermodynamics, etc. Among the most common factors affecting skin permeation of nanoparticles that are discussed include size, shape, surface charge density, composition of nanoparticles, mechanical stress, pH, etc.

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