Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification

2020 ◽  
Vol 30 (13) ◽  
pp. 1908865 ◽  
Author(s):  
Jingjing Liu ◽  
Min Wu ◽  
Yutong Pan ◽  
Yukun Duan ◽  
Ziliang Dong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Combination Therapy ◽  
Coordination Polymers ◽  
Stress Amplification ◽  
Nanoscale Coordination Polymers

Cisplatin Resistance Reversal of Lung Cancers by Tumor Acidity-Activable Vesicular Nanoreactors via Tumor Oxidative Stress Amplification

2021 ◽  
Author(s):  
Jean Felix Mukerabigwi ◽  
Yu Han ◽  
Nannan Lu ◽  
Wendong Ke ◽  
Yuheng Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Therapeutic Efficacy ◽  
Cisplatin Resistance ◽  
Clinical Applications ◽  
Lung Cancers ◽  
Resistance Reversal ◽  
Tumor Acidity ◽  
Stress Amplification ◽  
Novel Strategy

Drug resistance of cisplatin significantly limits its therapeutic efficacy in clinical applications against a variety of cancers. Herein, we develop a novel strategy to overcome cisplatin drug resistance through sensitizing...

Synthesis of Nanoscale Coordination Polymers in Femtoliter Reactors on Surfaces

ACS Nano ◽  
2016 ◽  
Vol 10 (3) ◽  
pp. 3206-3213 ◽  
Author(s):  
Mireia Guardingo ◽  
Pablo González-Monje ◽  
Fernando Novio ◽  
Elena Bellido ◽  
Félix Busqué ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Nanoscale Coordination Polymers

scholarly journals Melatonin synergistically enhances protective effect of atorvastatin against gentamicin-induced nephrotoxicity in rat kidney

2016 ◽  
Vol 94 (3) ◽  
pp. 265-271 ◽  
Author(s):  
Saeed Mehrzadi ◽  
Seyed Kamran Kamrava ◽  
Banafshe Dormanesh ◽  
Manijeh Motevalian ◽  
Azam Hosseinzadeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Combination Therapy ◽  
Serum Creatinine ◽  
Rat Kidney ◽  
Elevated Serum ◽  
Albino Rats ◽  
Kidney Weight ◽  
Sod Activity ◽  
Creatinine Concentration ◽  
Beneficial Effects

The risk of serious side-effects such as nephrotoxicity is the principal limitation of gentamicin (GEN) therapeutic efficacy. Oxidative stress is considered to be an important mediator of GEN-induced nephrotoxicity. The present study was designed to evaluate the efficacy of the combination of melatonin (MT) plus atorvastatin (ATO) against GEN-induced nephrotoxicity in rats. We utilized 30 male Wistar albino rats allocated in 5 groups, each containing 6 rats: control, GEN (100 mg/kg/day), ATO (10 mg/kg/day) + GEN, MT (20 mg/kg/day) + GEN, and ATO (10 mg/kg/day) plus MT (20 mg/kg/day) + GEN. Kidney weight, serum creatinine and urea concentration, renal ROS, MDA, GSH levels, SOD, and CAT activity were determined. GEN-induced nephrotoxicity was evidenced by marked elevations in serum urea and creatinine, kidney weight, renal ROS, and MDA levels and reduction in renal GSH level, SOD and CAT activity. MT pretreatment significantly lowered the elevated serum creatinine concentration, kidney weight, renal ROS and MDA levels. However ATO could not reduce these parameters, but similarly to MT, it was able to enhance the renal GSH level, CAT and SOD activity. In addition, a combination therapy of MT plus ATO enhanced the beneficial effects of ATO, while not changing the effects of MT effects or even improving them. The present study indicates that a combination therapy of MT plus ATO can attenuate renal injury in rats treated with GEN, possibly by reducing oxidative stress, and it seems that MT can enhance the beneficial effects of ATO.

scholarly journals Highly Effective Radioisotope Cancer Therapy with a Non-Therapeutic Isotope Delivered and Sensitized by Nanoscale Coordination Polymers

ACS Nano ◽  
2018 ◽  
Vol 12 (8) ◽  
pp. 7519-7528 ◽  
Author(s):  
Yu Chao ◽  
Chao Liang ◽  
Yu Yang ◽  
Guanglin Wang ◽  
Debabrata Maiti ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Coordination Polymers ◽  
Highly Effective ◽  
Nanoscale Coordination Polymers

Methotrexate–Mn2+ based nanoscale coordination polymers as a theranostic nanoplatform for MRI guided chemotherapy

2020 ◽  
Vol 8 (2) ◽  
pp. 712-719 ◽  
Author(s):  
Yan Wu ◽  
Li Xu ◽  
Jiwen Qian ◽  
Leilei Shi ◽  
Yue Su ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Antitumor Effects ◽  
Uniform Size ◽  
Mri Guided ◽  
Nanoscale Coordination Polymers

Methotrexate–Mn2+ based NCPs with uniform size and easy fabrication exhibited good MRI and excellent antitumor effects as a novel theranostic nanoplatform.

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