Transformable Nanoparticle‐Enabled Synergistic Elicitation and Promotion of Immunogenic Cell Death for Triple‐Negative Breast Cancer Immunotherapy

2019 ◽  
Vol 29 (45) ◽  
pp. 1905213 ◽  
Author(s):  
Chenfeng Xu ◽  
Yulin Yu ◽  
Yu Sun ◽  
Li Kong ◽  
Conglian Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Immunotherapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Immunogenic Cell Death

scholarly journals A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1954
Author(s):  
Diwakar Bastihalli Tukaramrao ◽  
Saloni Malla ◽  
Siddharth Saraiya ◽  
Ross Allen Hanely ◽  
Aniruddha Ray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mouse Bone Marrow ◽  
Immunogenic Cell Death ◽  
Mrna Levels ◽  
Tnf Α ◽  
Tnbc Cell Line ◽  
Stimulatory Capacity

Enhancing the tumor immunogenic microenvironment has been suggested to circumvent triple-negative breast cancer (TNBC) resistance and increase the efficacy of conventional chemotherapy. Here, we report a novel chemotherapeutic compound, TPH104, which induces immunogenic cell death in the TNBC cell line MDA-MB-231, by increasing the stimulatory capacity of dendritic cells (DCs), with an IC50 value of 140 nM. TPH104 (5 µM) significantly increased ATP levels in the supernatant and mobilized intracellular calreticulin to the plasma membrane in MDA-MB-231 cells, compared to cells incubated with the vehicle. Incubating MDA-MB-231 cells for 12 h with TPH104 (1–5 µM) significantly increased TNF-α mRNA levels. The supernatants of dying MDAMB-231 cells incubated with TPH104 increased mouse bone marrow-derived DC maturation, the expression of MHC-II and CD86 and the mRNA expression of TNF-α, IL-6 and IL-12. Overall, these results indicate that TPH104 induces immunogenic cell death in TNBC cells, in part, by activating DCs.

scholarly journals Hypoxia Targeting Nanoparticles for Immunogenic Cell Death of Triple Negative Breast Cancer

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Ketki Bhise ◽  
Samaresh Sau ◽  
Mohd Ahmar Rauf ◽  
Rami Alzhrani ◽  
Arun Iyer
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Immunogenic Cell Death

scholarly journals Induction of Triple-negative Breast Cancer Cells to Immunogenic Cell Death and Increase Cross-Presentation by Streptomyces sanyensis

2021 ◽  
Vol 13 (3) ◽  
pp. 165-172
Author(s):  
Xingguo Quan ◽  
Ji-Young Lee ◽  
Jin Hee Park ◽  
Md. Masudul Haque ◽  
Hee Yeon Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Immunogenic Cell Death ◽  
Cross Presentation
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