Fluorinated Polyethylenimine to Enable Transmucosal Delivery of Photosensitizer‐Conjugated Catalase for Photodynamic Therapy of Orthotopic Bladder Tumors Postintravesical Instillation

2019 ◽  
Vol 29 (40) ◽  
pp. 1901932 ◽  
Author(s):  
Guangzhi Li ◽  
Simin Yuan ◽  
Dashi Deng ◽  
Tong Ou ◽  
Yuqing Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumors ◽  
Transmucosal Delivery

scholarly journals Whole bladder wall photodynamic therapy using a newly designed light-scattering device for bladder tumors

1988 ◽  
Vol 8 (4) ◽  
pp. 11-17
Author(s):  
Tadao Uchibayashi ◽  
Haruo Hisazumi ◽  
Toshimitsu Misaki ◽  
Shinya Mihara ◽  
Toshiyasu Amano ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Scattering ◽  
Bladder Wall ◽  
Bladder Tumors

scholarly journals Transurethral Resection of Non-Muscle Invasive Bladder Tumors Combined with Fluorescence Diagnosis and Photodynamic Therapy with Chlorin e6-Type Photosensitizers

2021 ◽  
Vol 11 (1) ◽  
pp. 233
Author(s):  
Andrey V. Kustov ◽  
Nataliya L. Smirnova ◽  
Oleg A. Privalov ◽  
Tatyana M. Moryganova ◽  
Alexander I. Strelnikov ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Photodynamic Therapy ◽  
Transurethral Resection ◽  
Red Light ◽  
Chlorin E6 ◽  
High Recurrence Rate ◽  
Common Disease ◽  
Bladder Tumors ◽  
Fluorescence Diagnosis ◽  
Muscle Invasive

Bladder cancer is a common disease with a high recurrence rate. In order to improve the treatment of superficial bladder tumors, we evaluated the efficacy and safety of transurethral resection (TURB) followed by fluorescence diagnosis (FD) and photodynamic therapy (PDT) with chlorin e6 photosensitizers (PSs), viz. “Fotoran e6” and “Fotoditazin”. It was found that both PSs generated singlet oxygen and revealed moderate affinity toward the lipid-like compartment. Between November 2018 and October 2020, 12 patients with verified non-muscle invasive bladder cancer (NMIBC) were treated by TURB combined with FD and PDT. Eight patients received “Fotoran e6” intravenously, while four patients received intravesical PSs. The patient ages were between 31 and 79 years, with a median age of 64.5 years (mean 61.3 ± 14.2). The total light dose was 150 J/cm2 for the local irradiation of the tumor bed with a red light at the λ = 660 nm wavelength, and 10–25 J/cm2 were additionally delivered for diffuse irradiation of the entire bladder mucosa. At the median follow-up period of 24 months (mean 24.5 ± 5.4 months, range 16–35 months), 11 patients remained tumor-free. One 79-year-old patient developed a recurrence without progression to the muscle layer. This pilot study shows that the TURB + FD + PDT technique is an effective and safe option for the first-line treatment of superficial bladder tumors.

scholarly journals Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin

2003 ◽  
Vol 107 (3) ◽  
pp. 460-467 ◽  
Author(s):  
Appolinary A.R. Kamuhabwa ◽  
Tania Roskams ◽  
Marie-Ange D'Hallewin ◽  
Luc Baert ◽  
Hein Van Poppel ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Wall ◽  
Transitional Cell ◽  
Bladder Tumors ◽  
Rat Bladder

scholarly journals Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: Implication for whole bladder wall photodynamic therapy

2001 ◽  
Vol 97 (2) ◽  
pp. 253-260 ◽  
Author(s):  
Appolinary A.R. Kamuhabwa ◽  
Isabelle Cosserat-Gerardin ◽  
Jacques Didelon ◽  
Dominique Notter ◽  
Fran�ois Guillemin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Wall ◽  
Transitional Cell ◽  
Bladder Tumors
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