Dual‐Action Flexible Antimicrobial Material: Switchable Self‐Cleaning, Antifouling, and Smart Drug Release

2019 ◽  
Vol 29 (31) ◽  
pp. 1901880 ◽  
Author(s):  
Lukáš Děkanovský ◽  
Roman Elashnikov ◽  
Markéta Kubiková ◽  
Barbora Vokatá ◽  
Václav Švorčík ◽  
...  
Keyword(s):  
Drug Release ◽  
Antimicrobial Material ◽  
Dual Action ◽  
Self Cleaning ◽  
Smart Drug

Smart Drug Release Systems Based on Stimuli-Responsive Polymers

2013 ◽  
Vol 13 (9) ◽  
pp. 1369-1380 ◽  
Author(s):  
Guangyan Qing ◽  
Minmin Li ◽  
Lijing Deng ◽  
Ziyu Lv ◽  
Peng Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Smart Drug

Cancer Treatment: Medibots: Dual-Action Biogenic Microdaggers for Single-Cell Surgery and Drug Release (Adv. Mater. 5/2016)

2016 ◽  
Vol 28 (5) ◽  
pp. 785-785 ◽  
Author(s):  
Sarvesh Kumar Srivastava ◽  
Mariana Medina-Sánchez ◽  
Britta Koch ◽  
Oliver G. Schmidt
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Single Cell ◽  
Dual Action ◽  
Cell Surgery

Medibots: Dual-Action Biogenic Microdaggers for Single-Cell Surgery and Drug Release

2015 ◽  
Vol 28 (5) ◽  
pp. 832-837 ◽  
Author(s):  
Sarvesh Kumar Srivastava ◽  
Mariana Medina-Sánchez ◽  
Britta Koch ◽  
Oliver G. Schmidt
Keyword(s):  
Drug Release ◽  
Single Cell ◽  
Dual Action ◽  
Cell Surgery

“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry

2016 ◽  
Vol 52 (74) ◽  
pp. 11151-11154 ◽  
Author(s):  
Liyang Shi ◽  
Yuanyuan Han ◽  
Jöns Hilborn ◽  
Dmitri Ossipov
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Acidic Environment ◽  
Self Healing ◽  
Nanoparticle Delivery ◽  
Neutral Ph ◽  
Smart Drug

A new self-healing hydrogel is developed using dynamic coordinate bonds between drug loaded MgSiO3 nanoparticles and bisphosphonate functionalized hyaluronic acid. The nanocomposite network is stable at neutral pH, but is disassembled in an acidic environment, providing “smart” drug release.

In situ hydrogelation of bicalutamide-peptide conjugates at prostate tissue for smart drug release based on pH and enzymatic activity

Nanoscale ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 5030-5037 ◽  
Author(s):  
Suyun He ◽  
Leixia Mei ◽  
Can Wu ◽  
Mingtao Tao ◽  
Ziran Zhai ◽  
...  
Keyword(s):  
Drug Release ◽  
Enzymatic Activity ◽  
Self Assembly ◽  
Prostate Tissue ◽  
Cancer Drug ◽  
Peptide Conjugates ◽  
Anti Cancer ◽  
Peptide Derivatives ◽  
Smart Drug

The integration of an anti-cancer drug bicalutamide with tissue-specific supramolecular self-assembly of peptide derivatives yielded in situ hydrogelation at prostate tissue for smart drug release.

Engineering Nanomaterials for Smart Drug Release

2019 ◽  
pp. 411-449 ◽  
Author(s):  
Akhilesh K. Singh ◽  
Thakur P. Yadav ◽  
Brijesh Pandey ◽  
Vinay Gupta ◽  
Satarudra P. Singh
Keyword(s):  
Drug Release ◽  
Smart Drug

scholarly journals Biocompatible Coatings from Smart Biopolymer Nanoparticles for Enzymatically Induced Drug Release

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 103 ◽  
Author(s):  
Christian Tolle ◽  
Jan Riedel ◽  
Carina Mikolai ◽  
Andreas Winkel ◽  
Meike Stiesch ◽  
...  
Keyword(s):  
Drug Release ◽  
Photoelectron Spectroscopy ◽  
Release Kinetics ◽  
Drug Loading ◽  
Peptide Sequence ◽  
Adhesion Properties ◽  
Hydrogel Nanoparticles ◽  
Ionotropic Gelation ◽  
Peptide Coatings ◽  
Smart Drug

Nanoparticles can be used as a smart drug delivery system, when they release the drug only upon degradation by specific enzymes. A method to create such responsive materials is the formation of hydrogel nanoparticles, which have enzymatically degradable crosslinkers. Such hydrogel nanoparticles were prepared by ionotropic gelation sodium alginate with lysine-rich peptide sequences—either α-poly-L-lysine (PLL) or the aggrecanase-labile sequence KKKK-GRD-ARGSV↓NITEGE-DRG-KKKK. The nanoparticle suspensions obtained were analyzed by means of dynamic light scattering and nanoparticle tracking analysis. Degradation experiments carried out with the nanoparticles in suspension revealed enzyme-induced lability. Drugs present in the polymer solution during the ionotropic gelation can be encapsulated in the nanoparticles. Drug loading was investigated for interferon- (IFN-) as a model, using a bioluminescence assay with MX2Luc2 cells. The encapsulation efficiency for IFN- was found to be approximately 25%. The nanoparticles suspension can be used to spray-coat titanium alloys (Ti-6Al-4V) as a common implant material. The coatings were proven by ellipsometry, reflection-absorption infrared spectroscopy, and X-ray photoelectron spectroscopy. An enzyme-responsive decrease in layer thickness is observed due to the degradation of the coatings. The Alg/peptide coatings were cytocompatible for human gingival fibroblasts (HGFIB), which was investigated by CellTiterBlue and lactate dehydrogenase (LDH) assay. However, HGFIBs showed poor adhesion and proliferation on the Alg/peptide coatings, but these could be improved by modification of the alginate with a RGD-peptide sequence. The smart drug release system presented can be further tailored to have the right release kinetics and cell adhesion properties.

Ultrasound-Triggered Smart Drug Release from Multifunctional Core−Shell Capsules One-Step Fabricated by Coaxial Electrospray Method

Langmuir ◽  
2011 ◽  
Vol 27 (3) ◽  
pp. 1175-1180 ◽  
Author(s):  
Yujia Jing ◽  
Yihua Zhu ◽  
Xiaoling Yang ◽  
Jianhua Shen ◽  
Chunzhong Li
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
One Step ◽  
Smart Drug ◽  
Coaxial Electrospray
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