PDT-Driven Highly Efficient Intracellular Delivery and Controlled Release of CO in Combination with Sufficient Singlet Oxygen Production for Synergistic Anticancer Therapy

2018 ◽  
Vol 28 (41) ◽  
pp. 1804324 ◽  
Author(s):  
Lihuang Wu ◽  
Xiaojun Cai ◽  
Haofang Zhu ◽  
Junhua Li ◽  
Dongxu Shi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Singlet Oxygen ◽  
Intracellular Delivery ◽  
Anticancer Therapy ◽  
Oxygen Production ◽  
Highly Efficient

scholarly journals Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6618
Author(s):  
Ruth Prieto-Montero ◽  
Alejandro Prieto-Castañeda ◽  
Alberto Katsumiti ◽  
Miren P. Cajaraville ◽  
Antonia R. Agarrabeitia ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Absorption Capacity ◽  
Oxygen Production ◽  
Photodynamic Therapy Of Cancer ◽  
Custom Made ◽  
Fluorescence Efficiency ◽  
Covalently Linked

BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10–15 J/cm2) were compared with PSs free in solution in HeLa cells in vitro.

Control of singlet oxygen production in experiments performed on single mammalian cells

2016 ◽  
Vol 321 ◽  
pp. 297-308 ◽  
Author(s):  
Michael Westberg ◽  
Mikkel Bregnhøj ◽  
Alfonso Blázquez-Castro ◽  
Thomas Breitenbach ◽  
Michael Etzerodt ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Mammalian Cells ◽  
Oxygen Production
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