Structure-Guided Engineering of Cytotoxic Cabazitaxel for an Adaptive Nanoparticle Formulation: Enhancing the Drug Safety and Therapeutic Efficacy

2018 ◽  
Vol 28 (52) ◽  
pp. 1804229 ◽  
Author(s):  
Jianqin Wan ◽  
Yiting Qiao ◽  
Xiaona Chen ◽  
Jiaping Wu ◽  
Liqian Zhou ◽  
...  
Keyword(s):  
Drug Safety ◽  
Therapeutic Efficacy ◽  
Nanoparticle Formulation

scholarly journals An esterase-activatable prodrug formulated liposome strategy: potentiating the anticancer therapeutic efficacy and drug safety

2022 ◽  
Author(s):  
Linlin Shi ◽  
Xinkai Wu ◽  
Tongyu Li ◽  
Yuan Wu ◽  
Liwei Song ◽  
...  
Keyword(s):  
Drug Safety ◽  
Therapeutic Efficacy ◽  
Hydrophilic Drugs ◽  
Liposomal System

Liposomal nanomedicine represents a common and versatile carrier for the delivery of both lipophilic and hydrophilic drugs. However, the direct formulation of many chemotherapeutics into a liposomal system remains an...

FDA's New Drug Safety Board Under Scrutiny

2005 ◽  
Vol 39 (3) ◽  
pp. 51
Author(s):  
JENNIFER SILVERMAN
Keyword(s):  
Drug Safety ◽  
New Drug

FDA Plans to Strengthen Drug Safety Program

2005 ◽  
Vol 36 (1) ◽  
pp. 43
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Drug Safety ◽  
Safety Program

Photographic evaluation of therapeutic efficacy

1968 ◽  
Vol 97 (3) ◽  
pp. 258-261
Author(s):  
H. M. Robinson
Keyword(s):  
Therapeutic Efficacy

Therapeutic efficacy of some extracts of hot pepper fruits (Capsicum annuum) and Sumac seeds (Rhus coriaria) on the growth of some isolated dermatophytes species

2018 ◽  
Vol 1 (3) ◽  
pp. 52-62
Author(s):  
Sara Omran ◽  
Abdulghani Alsamarai ◽  
Firas Razzzaq
Keyword(s):  
Antifungal Activity ◽  
Fungal Infection ◽  
Aqueous Extract ◽  
Plant Extracts ◽  
Therapeutic Efficacy ◽  
Diffusion Method ◽  
Quantitative Detection ◽  
Hot Pepper ◽  
Alcoholic Extract ◽  
Dermatology Clinic

Background: Fungal infections are one of the common skin diseases with difficulty in their treatment approach. The present efficient drugs for fungal infection are limited. Aim: To determine the therapeutic efficacy of plant extracts as alternative antifungal agents. Materials and methods: 100 clinical samples [68 from female and 32 from male] were collected during the period from March to July 2017 from subjects attending Dermatology Clinic in Salah Uldean General Hospital. Fungal infection was diagnosed with using KOH wet preparation. Fungal species identified by using conventional approach. The active ingredients existing in the plant extracts were detected and analyzed through qualitative and quantitative detection technique of chemical compounds using a high performance liquid chromatographic device (HPLC). Agar diffusion method was used to determine antifungal activity of plant extracts. Results: Direct microscopic examination showed that there were (75%) positive samples, while culture shows (67%) positive samples. The isolated dermatophytes belong to Epidermophyoton, Microsporum, and Trichophyton genus. The predominant dermatophytes were T. rubrum (25%) species. The highest frequency of infection was in the age group of 11-20 years. The sensitivity of the tested fungi to the aqueous and alcoholic plant extracts varies. Alcoholic extract of the hot pepper plant was more effective as antifungal than the aqueous extract of the same plant. However, aqueous hot pepper extracts was more effective against T. mentagrophyte than that of alcoholic extract. Additionally, alcoholic Sumac extract shows higher efficacy that aqueous extract. Conclusion: Hot pepper and Sumac extracts show antifungal activity against Microsporum canis, Trichophyton rubrum and T. mentagrophyte.

Sign in / Sign up

Export Citation Format

Share Document