scholarly journals Photoacoustic Imaging: Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging (Adv. Funct. Mater. 8/2017)

2017 ◽  
Vol 27 (8) ◽  
Author(s):  
Chen Xie ◽  
Xu Zhen ◽  
Qunli Lei ◽  
Ran Ni ◽  
Kanyi Pu
Keyword(s):  
Self Assembly ◽  
Photoacoustic Imaging ◽  
Semiconducting Polymer

scholarly journals Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging

2017 ◽  
Vol 27 (8) ◽  
pp. 1605397 ◽  
Author(s):  
Chen Xie ◽  
Xu Zhen ◽  
Qunli Lei ◽  
Ran Ni ◽  
Kanyi Pu
Keyword(s):  
Self Assembly ◽  
Photoacoustic Imaging ◽  
Semiconducting Polymer

Organic Nanotheranostics for Photoacoustic Imaging-Guided Phototherapy

2019 ◽  
Vol 26 (8) ◽  
pp. 1389-1405 ◽  
Author(s):  
Houjuan Zhu ◽  
Chen Xie ◽  
Peng Chen ◽  
Kanyi Pu
Keyword(s):  
Photoacoustic Imaging ◽  
Imaging Modality ◽  
Diagnostic Methods ◽  
Therapeutic Window ◽  
Great Promise ◽  
Semiconducting Polymer ◽  
Avant Garde ◽  
Nir Dyes ◽  
Organic Nanomaterials

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have emerged as one of the avant-garde strategies for cancer treatment. Photoacoustic (PA) imaging is a new hybrid imaging modality that shows great promise for real-time in vivo monitoring of biological processes with deep tissue penetration and high spatial resolution. To enhance therapeutic efficacy, reduce side effects and minimize the probability of over-medication, it is necessary to use imaging and diagnostic methods to identify the ideal therapeutic window and track the therapeutic outcome. With this regard, nanotheranostics with the ability to conduct PA imaging and PTT/PDT are emerging. This review summarizes the recent progress of organic nanomaterials including nearinfrared (NIR) dyes and semiconducting polymer nanoparticles (SPNs) in PA imaging guided cancer phototherapy, and also addresses their present challenges and potential in clinical applications.

scholarly journals Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging

Biomaterials ◽  
2017 ◽  
Vol 119 ◽  
pp. 1-8 ◽  
Author(s):  
Chen Xie ◽  
Paul Kumar Upputuri ◽  
Xu Zhen ◽  
Manojit Pramanik ◽  
Kanyi Pu
Keyword(s):  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Semiconducting Polymer Nanoparticles

scholarly journals Diketopyrrolopyrrole-Based Semiconducting Polymer Nanoparticles for In Vivo Photoacoustic Imaging

2015 ◽  
Vol 27 (35) ◽  
pp. 5184-5190 ◽  
Author(s):  
Kanyi Pu ◽  
Jianguo Mei ◽  
Jesse V. Jokerst ◽  
Guosong Hong ◽  
Alexander L. Antaris ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Semiconducting Polymer Nanoparticles

Semiconducting polymer-based nanoparticles with strong absorbance in NIR-II window for in vivo photothermal therapy and photoacoustic imaging

Biomaterials ◽  
2018 ◽  
Vol 155 ◽  
pp. 103-111 ◽  
Author(s):  
Ziyang Cao ◽  
Liangzhu Feng ◽  
Guobing Zhang ◽  
Junxia Wang ◽  
Song Shen ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Semiconducting Polymer

1300 nm absorption two-acceptor semiconducting polymer nanoparticles for NIR-II photoacoustic imaging system guided NIR-II photothermal therapy

2019 ◽  
Vol 55 (64) ◽  
pp. 9487-9490 ◽  
Author(s):  
Wansu Zhang ◽  
Xiaoli Sun ◽  
Ting Huang ◽  
Xiaoxia Pan ◽  
Pengfei Sun ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Semiconducting Polymer Nanoparticles

1300 nm absorption SPNs were designed to realize in vivo NIR-II PTT treatment guided by commercial NIR-II PAI systems.

In vitro and in vivo polysaccharides assembly: ultrastructural and cytochemical study of growing plant cell wall components.

1978 ◽  
Vol 36 (2) ◽  
pp. 434-435
Author(s):  
D. Reis ◽  
B. Vian ◽  
J. C. Roland
Keyword(s):  
Cell Wall ◽  
Self Assembly ◽  
Plant Cell Wall ◽  
Higher Plants ◽  
Three Dimensional ◽  
Cytochemical Study ◽  
Wall Components

Wall morphogenesis in higher plants is a problem still open to controversy. Until now the possibility of a transmembrane control and the involvement of microtubules were mostly envisaged. Self-assembly processes have been observed in the case of walls of Chlamydomonas and bacteria. Spontaneous gelling interactions between xanthan and galactomannan from Ceratonia have been analyzed very recently. The present work provides indications that some processes of spontaneous aggregation could occur in higher plants during the formation and expansion of cell wall.Observations were performed on hypocotyl of mung bean (Phaseolus aureus) for which growth characteristics and wall composition have been previously defined.In situ, the walls of actively growing cells (primary walls) show an ordered three-dimensional organization (fig. 1). The wall is typically polylamellate with multifibrillar layers alternately transverse and longitudinal. Between these layers intermediate strata exist in which the orientation of microfibrils progressively rotates. Thus a progressive change in the morphogenetic activity occurs.

Programmable in vitro Co-Encapsidation of Guest Proteins Inside Protein Nanocages

2018 ◽  
Author(s):  
Noor H. Dashti ◽  
Rufika S. Abidin ◽  
Frank Sainsbury
Keyword(s):  
Self Assembly ◽  
Mammalian Cells ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Super Resolution ◽  
Cell Engineering ◽  
Particle Analysis ◽  
Protein Cages

Bioinspired self-sorting and self-assembling systems using engineered versions of natural protein cages have been developed for biocatalysis and therapeutic delivery. The packaging and intracellular delivery of guest proteins is of particular interest for both <i>in vitro</i> and <i>in vivo</i> cell engineering. However, there is a lack of platforms in bionanotechnology that combine programmable guest protein encapsidation with efficient intracellular uptake. We report a minimal peptide anchor for <i>in vivo</i> self-sorting of cargo-linked capsomeres of the Murine polyomavirus (MPyV) major coat protein that enables controlled encapsidation of guest proteins by <i>in vitro</i> self-assembly. Using Förster resonance energy transfer (FRET) we demonstrate the flexibility in this system to support co-encapsidation of multiple proteins. Complementing these ensemble measurements with single particle analysis by super-resolution microscopy shows that the stochastic nature of co-encapsidation is an overriding principle. This has implications for the design and deployment of both native and engineered self-sorting encapsulation systems and for the assembly of infectious virions. Taking advantage of the encoded affinity for sialic acids ubiquitously displayed on the surface of mammalian cells, we demonstrate the ability of self-assembled MPyV virus-like particles to mediate efficient delivery of guest proteins to the cytosol of primary human cells. This platform for programmable co-encapsidation and efficient cytosolic delivery of complementary biomolecules therefore has enormous potential in cell engineering.

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