scholarly journals Rational Synthesis of Large-Area Periodic Chemical Gradients for the Manipulation of Liquid Droplets and Gas Bubbles

2018 ◽  
Vol 28 (8) ◽  
pp. 1705564 ◽  
Author(s):  
Karla Perez-Toralla ◽  
Abhiteja Konda ◽  
John J. Bowen ◽  
Emily E. Jennings ◽  
Christos Argyropoulos ◽  
...  
Langmuir ◽  
2013 ◽  
Vol 29 (11) ◽  
pp. 3594-3603 ◽  
Author(s):  
Louxiang Wang ◽  
David Sharp ◽  
Jacob Masliyah ◽  
Zhenghe Xu

Author(s):  
Joseph L. Bull ◽  
Andre´s J. Caldero´n ◽  
Yun Seok Heo ◽  
Dongeun Huh ◽  
Nobuyuki Futai ◽  
...  

Embolotherapy involves the occlusion of blood flow to tumors to treat a variety of cancers, including renal carcinoma and hepatocellular carcinoma. The accompanying liver cirrhosis makes the treatment of hepatocellular carcinoma by traditional methods difficult. Previous attempts at embolotherapy have used solid emboli. A major difficulty in embolotherapy is restricting delivery of the emboli to the tumor. We are developing a novel minimally invasive gas embolotherapy technique that uses gas bubbles rather than solid emboli. The bubbles originate as encapsulated liquid droplets that are small enough to pass through capillaries. The droplets can be selectively vaporized in vivo by focused high intensity ultrasound to form gas bubbles which are then sufficiently large to lodge in the tumor vasculature. We investigated the dynamics of bubble lodging in microfluidic model bifurcations made of poly(dimethylsiloxane) and in theoretical analyses. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. Based these results, we estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.


2016 ◽  
Vol 47 (1) ◽  
pp. 1649-1652
Author(s):  
Xiahui Wang ◽  
Guoqing Zhang ◽  
Hongwen Ren

Nanophotonics ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 367-390 ◽  
Author(s):  
Ivan S. Maksymov ◽  
Andrew D. Greentree

AbstractNonlinear optical processes are vital for fields including telecommunications, signal processing, data storage, spectroscopy, sensing and imaging. As an independent research area, nonlinear optics began with the invention of the laser, because practical sources of intense light needed to generate optical nonlinearities were not previously available. However, the high power requirements of many nonlinear optical systems limit their use, especially in portable or medical applications, and so there is a push to develop new materials and resonant structures capable of producing nonlinear optical phenomena with low-power light emitted by inexpensive and compact sources. Acoustic nonlinearities, especially giant acoustic nonlinear phenomena in gas bubbles and liquid droplets, are much stronger than their optical counterparts. Here, we suggest employing acoustic nonlinearities to generate new optical frequencies, thereby effectively reproducing nonlinear optical processes without the need for laser light. We critically survey the current literature dedicated to the interaction of light with nonlinear acoustic waves and highly nonlinear oscillations of gas bubbles and liquid droplets. We show that the conversion of acoustic nonlinearities into optical signals is possible with low-cost incoherent light sources such as light-emitting diodes, which would usher new classes of low-power photonic devices that are more affordable for remote communities and developing nations, or where there are demanding requirements on size, weight and power.


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